LAR

LATRUNCULIN A

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is present as a standalone ligand in 18 entries

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Chemical Component Summary
Name	LATRUNCULIN A
Synonyms	4-(17-HYDROXY-5,12-DIMETHYL-3-OXO-2,16-DIOXABICYCLO[13.3.1]NONADECA-4,8,10-TRIEN-17-YL)-2-THIAZOLIDINONE
Identifiers	(4R)-4-[(1R,4S,5Z,7E,11Z,15R,17R)-17-hydroxy-4,11-dimethyl-13-oxo-14,18-dioxabicyclo[13.3.1]nonadeca-5,7,11-trien-17-yl]-1,3-thiazolidin-2-one
Formula	C₂₂ H₃₁ N O₅ S
Molecular Weight	421.55
Type	NON-POLYMER
Isomeric SMILES	C[C@H]/1CC[C@@H]2C[C@H](C[C@@](O2)([C@@H]3CSC(=O)N3)O)OC(=O)/C=C(\CC/C=C/C=C1)/C
InChI	InChI=1S/C22H31NO5S/c1-15-7-5-3-4-6-8-16(2)11-20(24)27-18-12-17(10-9-15)28-22(26,13-18)19-14-29-21(25)23-19/h3-5,7,11,15,17-19,26H,6,8-10,12-14H2,1-2H3,(H,23,25)/b4-3+,7-5-,16-11-/t15-,17-,18-,19+,22-/m1/s1
InChIKey	DDVBPZROPPMBLW-IZGXTMSKSA-N

Chemical Details
Formal Charge	0
Atom Count	60
Chiral Atom Count	5
Bond Count	62
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB02621 ?
Name	Latrunculin A
Groups	experimental
Description	Latrunculin A is an actin binding macrolide purified from the red sea sponge Latrunculia magnifica. It is under investigation for the treatment of cancer. It disrupts actin polymerization, prevents mitotic spindle formation and thus cell replication.
Synonyms	LatA (4R)-4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-1,3-thiazolidin-2-one LAT-A (+)-latrunculin A Latrunculin A
Categories	Porifera Sulfur Compounds Thiazoles
CAS number	76343-93-6

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Actin, alpha skeletal muscle	MCDEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMG...	unknown	inhibitor
Gelsolin	MAPHRPAPALLCALSLALCALSLPVRAATASRGASQAGAPQGRVPEARPN...	unknown
Iota toxin component Ia	MKKVNKSISVFLILYLILTSSFPSYTYAQDLQIASNYITDRAFIERPEDF...	unknown

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682