LDP

L-DOPAMINE

Find entries where: LDP

is present as a standalone ligand in 32 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 2 entries

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Chemical Component Summary
Name	L-DOPAMINE
Synonyms	DOPAMINE
Identifiers	4-(2-aminoethyl)benzene-1,2-diol
Formula	C₈ H₁₁ N O₂
Molecular Weight	153.178
Type	NON-POLYMER
Isomeric SMILES	c1cc(c(cc1CCN)O)O
InChI	InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2
InChIKey	VYFYYTLLBUKUHU-UHFFFAOYSA-N

Chemical Details
Formal Charge	0
Atom Count	22
Chiral Atom Count	0
Bond Count	22
Aromatic Bond Count	6

Drug Info: DrugBank

DrugBank ID	DB00988 ?
Name	Dopamine
Groups	approved
Description	One of the catecholamine neurotransmitters in the brain. It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action.
Synonyms	Dopamina Dopaminum 3-Hydroxytyramine 4-(2-aminoethyl)pyrocatechol 4-(2-aminoethyl)-1,2-benzenediol 2-(3,4-dihydroxyphenyl)ethylamine 3,4-Dihydroxyphenethylamine Dopamine 4-(2-Aminoethyl)benzene-1,2-diol 4-(2-aminoethyl)catechol Dopamine hydrochloride Oxytyramine
Brand Names	Dopamine Hydrochloride and 5% Dextrose Injection USP DOPamine Hydrochloride Dopamine Hydrochloride in Dextrose Dopamine Hydrochloride DOPamine HYDROCHLORIDE AND DEXTROSE Dopamine HCl Dopamine HCl 0.8mg/ml Dextrose 5% Inj USP Dopamine HCl Inj 4% DOPamine Hydrochloride and Dextrose Myocard-DX Dopamine Dopamine Hydrochloride and Dextrose Dopamine Hci In 5% Dextrose Dopamine HCl 3.2mg/ml Dextrose 5% Inj USP Intropin Injection 40mg/ml Dopamine HCl 1.6mg/ml Dextrose 5% Inj USP Dopamine Hci
Indication	For the correction of hemodynamic imbalances present in the shock syndrome due to myocardial infarction, trauma, endotoxic septicemia, open-heart surgery, renal failure, and chronic cardiac decompensation as in congestive failure
Categories	Adrenergic and Dopaminergic Agents Agents producing tachycardia Agents that produce hypertension Amines Autonomic Agents Benzene Derivatives Biogenic Amines Biogenic Monoamines Cardiac Stimulants Excl. Cardiac Glycosides Cardiac Therapy Cardiotonic Agents Cardiovascular Agents Catecholamines Catechols Compounds used in a research, industrial, or household setting COMT Substrates Dopamine Agents Dopamine, metabolism Drugs that are Mainly Renally Excreted Monoamine Oxidase A Substrates Neurotransmitter Agents OCT1 substrates OCT2 Inhibitors OCT2 Substrates Peripheral Nervous System Agents Phenols Protective Agents Selective Beta 1-adrenergic Agonists Sympathomimetics
ATC-Code	C01CA04
CAS number	51-61-6

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Dopamine D2 receptor	MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVF...	unknown	agonist
Dopamine D1 receptor	MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIR...	unknown	agonist
Dopamine D5 receptor	MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLL...	unknown	agonist
Dopamine D3 receptor	MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLV...	unknown	agonist
Dopamine D4 receptor	MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLA...	unknown	agonist
Sodium-dependent dopamine transporter	MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNP...	unknown	inducer
Dopamine beta-hydroxylase	MPALSRWASLPGPSMREAAFMYSTAVAIFLVILVAALQGSAPRESPLPYH...	unknown	ligand
5-hydroxytryptamine receptor 1A	MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCA...	unknown	binder
5-hydroxytryptamine receptor 7	MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLS...	unknown	binder
D(1) dopamine receptor	MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIR...	unknown	agonist
Sodium-dependent noradrenaline transporter	MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRD...	unknown	inhibitor
Sodium-dependent serotonin transporter	METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAV...	unknown	inhibitor
5-hydroxytryptamine receptor 3A	MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVR...	unknown
5-hydroxytryptamine receptor 3B	MLSSVMAPLWACILVAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPV...	unknown
Superoxide dismutase [Cu-Zn]	MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHE...	unknown
Synaptic vesicular amine transporter	MALSELALVRWLQESRRSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYS...	unknown
Dopamine beta-hydroxylase	MPALSRWASLPGPSMREAAFMYSTAVAIFLVILVAALQGSAPRESPLPYH...	unknown	substrate
Amine oxidase [flavin-containing] A	MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGG...	unknown	substrate
Amine oxidase [flavin-containing] B	MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQK...	unknown	substrate
Catechol O-methyltransferase	MPEAPPLLLAAVLLGLVLLVVLLLLLRHWGWGLCLIGWNEFILQPIHNLL...	unknown	substrate
Solute carrier family 22 member 2	MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHR...	unknown	substrate,inhibitor
Solute carrier family 22 member 1	MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHC...	unknown	substrate
Solute carrier family 22 member 3	MPSFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYW...	unknown	inhibitor
Solute carrier family 22 member 5	MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRC...	unknown	inhibitor
POU domain, class 5, transcription factor 1	MAGHLASDFAFSPPPGGGGDGPGGPEPGWVDPRTWLSFQGPPGGPGIGPG...	unknown	substrate
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682