LYS

LYSINE

Created:	1999-07-08
Last modified:	2024-09-27

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188 entries where LYS is found as a standalone ligand67 entries where LYS is covalently linked to polymer or other heterogen groups 228,867 entries where LYS is found in a polymer sequence

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Chemical Details
Formal Charge	1
Atom Count	25
Chiral Atom Count	1
Bond Count	24
Aromatic Bond Count	0

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Chemical Component Summary
Name	LYSINE
Systematic Name (OpenEye OEToolkits)	[(5S)-5-amino-6-hydroxy-6-oxo-hexyl]azanium
Formula	C₆ H₁₅ N₂ O₂
Molecular Weight	147.195
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(N)CCCC[NH3+]
SMILES	CACTVS	3.341	N[CH](CCCC[NH3+])C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	C(CC[NH3+])CC(C(=O)O)N
Canonical SMILES	CACTVS	3.341	N[C@@H](CCCC[NH3+])C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C(CC[NH3+])C[C@@H](C(=O)O)N
InChI	InChI	1.03	InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1
InChIKey	InChI	1.03	KDXKERNSBIXSRK-YFKPBYRVSA-O

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00123 ?
Name	Lysine
Groups	nutraceutical approved
Description	Lysine (abbreviated as Lys or K) is an α-amino acid with the chemical formula HO2CCH(NH2)(CH2)4NH2. This amino acid is an essential amino acid, which means that humans cannot synthesize it. Its codons are AAA and AAG. Lysine is a base, as are arginine and histidine. The ε-amino group acts as a site for hydrogen binding and a general base in catalysis. Common posttranslational modifications include methylation of the ε-amino group, giving methyl-, dimethyl-, and trimethyllysine. The latter occurs in calmodulin. Other posttranslational modifications include acetylation. Collagen contains hydroxylysine which is derived from lysine by lysyl hydroxylase. O-Glycosylation of lysine residues in the endoplasmic reticulum or Golgi apparatus is used to mark certain proteins for secretion from the cell.
Synonyms	(S)-2,6-diaminohexanoic acid L-Lysin Lysinum Lysine Lysine dihydrate (S)-α,ε-diaminocaproic acid Lysine acid Lysine monohydrate L-Lysine Lysine hydrochloride L-lys (S)-lysine Lysina L-2,6-Diaminocaproic acid LYS 6-ammonio-L-norleucine Lysine acetate
Brand Names	TrophAmine Vamin N 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Aminosyn 7% 2.5% Travasol Amino Acid Injection Without Electrolytes In 10% Dextrose Quickmix Kabiven Olimel 3.3% E Clinimix Essepna Aminosyn II with Electrolytes in Dextrose with Calcium Aminosyn 3.5% M Aminosyn II 7% With 50% Dextrose Primene Aminosyn II 8.5% Injection 2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Aminosyn II with Electrolytes Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) Olimel 7.6% E ProcalAmine Aminosyn II 7% M In 10% Dextrose(dual Chamber) FreAmine HBC Smofkabiven Electrolyte Free FreAmine III Aminosyn 4.25% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Aminosyn-PF 10% 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. Aminosyn-PF 7% 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix 2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Quickmix Olimel 5.7% E 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Perikabiven Aminosyn-PF 4.25% Amino Acid Injection Without Electrolytes In 20% Dextrose Quickmix 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose Nutrineal Pd4 Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec Aminosyn 8.5% Aminosyn 10% W Electrolytes Olimel 5.7% Nephramine Liq IV Imubolic Aminosyn II 8.5% With 50% Dextrose 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Quickmix 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Plenamine 20% Prosol Aminosyn II In Dextrose Injection Smofkabiven Peripheral Aminosyn 8.5% Injection With Electrolytes Aminosyn HF Aminosyn Sulfite Free 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Travasol Inj Without Electrolytes 5.5% Renamin (amino Acids) Injection Vamin 18 Electrolyte-free Synthamin Aminosyn II and Dextrose Aminosyn II Effervescent Potassium Chloride Primene 10% 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex Periolimel 2.5% E Smofkabiven Extra Nitrogen Aminosyn II 10% With Electrolytes Clinisol Smofkabiven Aminosyn II 5% Inj 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Aminosyn II 7% With 10% Dextrose 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Travasol Inj Without Electrolytes 8.5% Primene 10%-liq IV Quick Mix 2.5% Travasol Aa With Electrolytes With 25% Dextrose Injec Olimel 4.4% Premasol - sulfite-free (Amino Acid) Olimel 7.6% Xyzmune Olimel 4.4% E 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Aminosyn II in Dextrose 4.25% Travasol Amino Acid Without Electrolytes In 5% Dextrose Quickmix Aminosyn 5% RenAmin Travasol Amino Acid Inj 8.5% Travasol Amino Acid Inj 5.5% Novamine Travasol Aminosyn RF Injection 4.25%travasol Amino Acid InJ.W.elecw.5%dex. 8.5% Freamine III Aminosyn II 7% Injection 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Travasol E HepatAmine Clinimix E Hepatasol NephrAmine ProSol Lysakare Smofkabiven Extra Nitrogen Electrolyte Free 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. Aminosyn RF
Indication	Supplemental lysine has putative anti-herpes simplex virus activity. There is preliminary research suggesting that it may have some anti-osteoporotic activity.
Categories	Amino Acids Amino Acids, Basic Amino Acids, Diamino Amino Acids, Essential Amino Acids, Peptides, and Proteins Blood and Blood Forming Organs Blood Substitutes and Perfusion Solutions Detoxifying Agents for Antineoplastic Treatment Dietary Supplements I.V. Solution Additives Lysine Proteinogenic Amino Acids Supplements
ATC-Code	V03AF11 B05XB03
CAS number	56-87-1

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
High affinity cationic amino acid transporter 1	MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGV...	unknown
Cationic amino acid transporter 4	MARGLPTIASLARLCQKLNRLKPLEDSTMETSLRRCLSTLDLTLLGVGGM...	unknown
Cationic amino acid transporter 3	MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGV...	unknown
Cationic amino acid transporter 2	MIPCRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGA...	unknown
Lysine--tRNA ligase	MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQ...	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	substrate,inhibitor
Solute carrier family 22 member 4	MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRC...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682