LYS

LYSINE

Created:	1999-07-08
Last modified:	2024-09-27

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182 entries where LYS is found as a standalone ligand67 entries where LYS is covalently linked to polymer or other heterogen groups 224,508 entries where LYS is found in a polymer sequence

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Chemical Details
Formal Charge	1
Atom Count	25
Chiral Atom Count	1
Bond Count	24
Aromatic Bond Count	0

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Chemical Component Summary
Name	LYSINE
Systematic Name (OpenEye OEToolkits)	[(5S)-5-amino-6-hydroxy-6-oxo-hexyl]azanium
Formula	C₆ H₁₅ N₂ O₂
Molecular Weight	147.195
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(N)CCCC[NH3+]
SMILES	CACTVS	3.341	N[CH](CCCC[NH3+])C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	C(CC[NH3+])CC(C(=O)O)N
Canonical SMILES	CACTVS	3.341	N[C@@H](CCCC[NH3+])C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C(CC[NH3+])C[C@@H](C(=O)O)N
InChI	InChI	1.03	InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1
InChIKey	InChI	1.03	KDXKERNSBIXSRK-YFKPBYRVSA-O

Drug Info: DrugBank

DrugBank ID	DB00123 ?
Name	Lysine
Groups	approved nutraceutical
Description	Lysine (abbreviated as Lys or K) is an α-amino acid with the chemical formula HO2CCH(NH2)(CH2)4NH2. This amino acid is an essential amino acid, which means that humans cannot synthesize it. Its codons are AAA and AAG. Lysine is a base, as are arginine and histidine. The ε-amino group acts as a site for hydrogen binding and a general base in catalysis. Common posttranslational modifications include methylation of the ε-amino group, giving methyl-, dimethyl-, and trimethyllysine. The latter occurs in calmodulin. Other posttranslational modifications include acetylation. Collagen contains hydroxylysine which is derived from lysine by lysyl hydroxylase. O-Glycosylation of lysine residues in the endoplasmic reticulum or Golgi apparatus is used to mark certain proteins for secretion from the cell.
Synonyms	L-Lysin Lysine dihydrate (S)-lysine Lysine hydrochloride L-lys Lysine acid (S)-α,ε-diaminocaproic acid Lysine Lysine acetate LYS (S)-2,6-diaminohexanoic acid 6-ammonio-L-norleucine Lysinum L-Lysine Lysine monohydrate L-2,6-Diaminocaproic acid Lysina
Brand Names	Olimel 3.3% E 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Quickmix 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Aminosyn-PF 10% 2.5% Travasol Amino Acid Injection Without Electrolytes In 10% Dextrose Quickmix Aminosyn II 7% Injection Nephramine Liq IV Vamin N Primene 10%-liq IV Aminosyn 10% W Electrolytes 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex 4.25% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix ProSol Aminosyn Sulfite Free Smofkabiven Peripheral 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Aminosyn II Nutrineal Pd4 Aminosyn-PF 7% Olimel 4.4% Aminosyn II and Dextrose HepatAmine Aminosyn II 8.5% With 50% Dextrose 20% Prosol Olimel 7.6% E Travasol Inj Without Electrolytes 8.5% 4.25%travasol Amino Acid InJ.W.elecw.5%dex. Smofkabiven Clinimix E 4.25% Amino Acid Injection Without Electrolytes In 20% Dextrose Quickmix 2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Quickmix Aminosyn II In Dextrose Injection Aminosyn II with Electrolytes Imubolic 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Aminosyn RF Perikabiven Vamin 18 Electrolyte-free Travasol E 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. Aminosyn II 8.5% Injection Travasol Amino Acid Inj 5.5% Aminosyn II with Electrolytes in Dextrose with Calcium 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose 4.25% Travasol Amino Acid Without Electrolytes In 5% Dextrose Quickmix Aminosyn II in Dextrose 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix Aminosyn RF Injection Primene Aminosyn HF Synthamin Olimel 5.7% E Travasol Aminosyn 3.5% M Olimel 7.6% RenAmin 8.5% Freamine III Olimel 4.4% E Aminosyn II 7% With 10% Dextrose Aminosyn-PF Essepna Aminosyn ProcalAmine 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose Smofkabiven Extra Nitrogen Electrolyte Free Effervescent Potassium Chloride Aminosyn II 7% M In 10% Dextrose(dual Chamber) Hepatasol 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Renamin (amino Acids) Injection 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Aminosyn 7% Xyzmune Periolimel 2.5% E Kabiven FreAmine HBC 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. FreAmine III Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) 2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Lysakare Primene 10% 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Aminosyn 8.5% Novamine Clinimix Aminosyn 8.5% Injection With Electrolytes Plenamine Travasol Amino Acid Inj 8.5% Aminosyn 5% Travasol Inj Without Electrolytes 5.5% Aminosyn II 5% Inj NephrAmine Smofkabiven Extra Nitrogen Aminosyn II 7% With 50% Dextrose Olimel 5.7% 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Quick Mix 2.5% Travasol Aa With Electrolytes With 25% Dextrose Injec Smofkabiven Electrolyte Free TrophAmine Aminosyn II 10% With Electrolytes Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec Premasol - sulfite-free (Amino Acid) Clinisol 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose
Indication	Supplemental lysine has putative anti-herpes simplex virus activity. There is preliminary research suggesting that it may have some anti-osteoporotic activity.
Categories	Amino Acids Amino Acids, Basic Amino Acids, Diamino Amino Acids, Essential Amino Acids, Peptides, and Proteins Blood and Blood Forming Organs Blood Substitutes and Perfusion Solutions Detoxifying Agents for Antineoplastic Treatment Dietary Supplements I.V. Solution Additives Lysine Proteinogenic Amino Acids Supplements
ATC-Code	V03AF11 B05XB03
CAS number	56-87-1

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
High affinity cationic amino acid transporter 1	MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGV...	unknown
Cationic amino acid transporter 4	MARGLPTIASLARLCQKLNRLKPLEDSTMETSLRRCLSTLDLTLLGVGGM...	unknown
Cationic amino acid transporter 3	MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGV...	unknown
Cationic amino acid transporter 2	MIPCRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGA...	unknown
Lysine--tRNA ligase	MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQ...	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	substrate,inhibitor
Solute carrier family 22 member 4	MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRC...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682