NCT

(S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE

Find entries where: NCT

is present as a standalone ligand in 20 entries

Find related ligands:

Chemical Component Summary
Name	(S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE
Synonyms	(S)-(-)-NICOTINE; 3-[(2S)-1-METHYL-2-PYRROLIDINYL] PYRIDINE
Identifiers	3-[(1R,2S)-1-methylpyrrolidin-2-yl]pyridine
Formula	C₁₀ H₁₄ N₂
Molecular Weight	162.232
Type	NON-POLYMER
Isomeric SMILES	C[N@@]1CCC[C@H]1c2cccnc2
InChI	InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1
InChIKey	SNICXCGAKADSCV-JTQLQIEISA-N

Chemical Details
Formal Charge	0
Atom Count	26
Chiral Atom Count	1
Bond Count	27
Aromatic Bond Count	6

Drug Info: DrugBank

DrugBank ID	DB00184 ?
Name	Nicotine
Groups	approved
Description	Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
Synonyms	3-(2-(N-methylpyrrolidinyl))pyridine Nikotin (S)-3-(N-methylpyrrolidin-2-yl)pyridine Nicotine L(?)-nicotine (S)-Nicotine Nicotine polacrilex (S)-3-(1-methylpyrrolidin-2-yl)pyridine Nicotine betadex Nicotine bitartrate dihydrate Nicotine bitartrate Nicotina Nikotyna 3-(N-methylpyrollidino)pyridine (?)-nicotine (S)-(?)-nicotine
Brand Names	Rugby Nicotine Nicotine Polacrilex coated fruit Nicotine Polacrilex coated ice mint Nicorette Fruit Chill Nicotine Resinate Nicotine transdermal system step 3 Up and Up Cherry Ice Nicotine CareOne Mini Nicotine Polacrilex Leader Nicotine Transdermal System Step 1 Leader Nicotine Transdermal System Step 2 Nicorette 4mg White Ice Mint Gum, Lil Drug Store In control nicotine Leader Nicotine Transdermal System Step 3 Preferred Plus Nicotine Nicotac Nicotine Polacrilex Coated Fruit Nicotine Polacrilex Original Flavor Good Sense Up and Up Mini Nicotine Polacrilex Nicorette White Ice Mint Good Sense Nicotine Good Sense Nicotine Stop Smoking Aid Smart Sense Nicotine Mint CareOne Nicotine Kirkland Signature Nicotine Nicotine Transdermal Rite Aid Nicotine Transdermal System Step 2 Healthmart Nicotine Transdermal System Step 2 Nicotine Polacrilex coated cinnamon Berkley and Jensen NICOTINE TopCare Nicotine Dg Health Nicotine Nicotine COATED ice mint Safeway Nicotine Transdermal System Step 2 Zonnic Topcare nicotine stop smoking aid Up and Up nicotine Nicotac Nicotine Polacrilex Coated Mint Topcare nicotine Healthmart Nicotine Transdermal System Step 1 Nicotine Polacrilex original Careone Nicotine Polacrilex Nicotine Polacrilex Origianl Flavor Berkley and Jensen Nicotine Equaline Nicotine Nicotine Lozenge Up and Up Nicotine CareOne Nicotine Transdermal System Step 2 Good Sense Nicotine Mint Topcare Nicotine Polacrilex Nicotine Polacrilex Stop Smoking Aid Rugby Nicotine Polacrilex Gum, Original Flavor Health Mart Nicotine Nicotine Transdermal Patches Kroger Nicotine Transdermal System Step 2 Habitrol Step 2 Up and Up Mini Nicotine Commit Nicorette Spearmint Burst Equate nicotine Zonnic Nicotine Basic Care nicotine Basic Care Nicotine Nicotac Nicotine Polacrilex Coated Cinnamon Nicoderm Trd 78mg Nicotine/14 Thrive Meijer NICOTINE TRANSDERMAL SYSTEM Step 1 Nicotine Coated Fruit Flavor Exchange Select Nicotine Euqate Nicotine Nicotine Polacrilex, Coated Mint Flavor Nicotine Sugar Free Sunmark Nicotine Transdermal System Step 1 Nicotine transdermal system step 1 Sunmark Nicotine Transdermal System Step 2 Nicotine Polacrilex Coated Ice Mint Equate Nicotine Sound Body Nicotine NICOTINE Transdermal System Step 3 Stop Smoking Aid Nicotine transdermal Equaline nicotine Nicotine UN1654 Signature Care Nicotine Meijer NICOTINE TRANSDERMAL SYSTEM Step 3 Smart Sense Nicotine Safeway Nicotine Transdermal System Step 1 Kirkland Signature Quit 2 Nicoderm Cq Smart Sense Nicotine Polacrilex Habitrol Step 1 Nicotine Polacrilex coated mint Exchange Select Nicotine Transdermal System Step 3 Nicotine In Control Nicotine Safeway Nicotine Transdermal System Step 3 DG Health nicotine Nicorette Cinnamon Surge Rite Aid Nicotine Transdermal System Step 3 Rugby Nicotine Polacrilex Gum, Coated Fruit Flavor Rugby Nicotine Polacrilex Gum, Coated Mint Flavor Nicotine Polacrilex Zonnic Nicotine Mini Nicotine Polacrilex Coated Mint Rugby Nicotine Polacrilex Gum, Mint Flavor Nicotine Polacrilex Coated Fruit Good Neighbor Pharmacy Nicotine Rite Aid Nicotine Transdermal System Step 1 Simply Right Nicotine Nicorette Gum 2mg American Fare Nicotine Transdermal System HEB Nicotine Nicotine Stop Smoking Aid Nicotrol Nicotine Polacrilex, Original Nicorette Original Nicotine polacrilex Nicotine Transdermal System in control Nicotine Foster and Thrive Nicotine Nicotine Polacrilex Original Nicotine transdermal system Sunmark Nicotine Nicotine Polacrilex Lozenge Mint Habitrol Patch Nicotine Transdermal System, Step 2 Kroger Nicotine Transdermal System Step 3 Habitrol Lozenge Cherry Healthmart Nicotine Transdermal System Step 3 Topcare Nicotine Tru Relief Nicotine Nicorette Plus 4mg Maxi Nicotine members mark Nicotine Habitrol Patch Nicotine Transdermal System, Step 3 NICOTINE Original Up and Up Cherry Nicotine Blip Nicotine Gum Preferred Plus Nicotine Polacrilex Gum, Original Flavor NICOTINE Transdermal System Step 2 Nicorette Cinnamon Surge nicotine polacrilex Nicotine Transdermal System Step 1 Lucy Nicotine Health Mart Nicotine Polacrilex equate Nicotine Members Mark Nicotine Lucy nicotine Nicorette 4mg Cinnamon Surge Berkley and Jensen Nicotine Polacrilex Members Mark Mini Nicotine Kirkland Signature Quit 4 Habitrol Lozenge Original Flavor Berkley and Jensen nicotine Nicorette and Aquafresh Fruit Chill and Extreme Clean Whitening Meijer NICOTINE TRANSDERMAL SYSTEM STEP 2 Habitrol Nicotine Polacrilex Lozenge Mint Stop Smoking Aid Nicotine NICOTINE Transdermal System Step 1 Nicotine transdermal system step 2 Habitrol Patch Nicotine Transdermal System, Step 1 Nicorette Care One Nicotine Health Mart nicotine polacrilex Mini Nicotine Nicotine Polacrilex Gum Harris Teeter Nicotine Kroger Nicotine Transdermal System Step 1 Nicotine Mint Flavor CareOne Nicotine Transdermal System Step 1 Good Neighbor Pharmacy Nicotine Mini Nicotrol (Professional Sample) Sunmark Nicotine Transdermal System Step 3 CareOne Nicotine Transdermal System Step 3 Leader Nicotine Topcare Nicotine Gum Nicorette 4mg Fruit Chill Gum, Lil Drug Store Up and Up Nicotine Polacrilex Nicorette White Mint nicotine polacrilex Nicorette Fruit Chill nicotine polacrilex Nicotine Polacrilex MINT Bjwc Nicotine Nicotine Polacrilex, Coated Fruit Flavor Rexall Nicotine Nicotine mini Nicotine Coated Mint Careone Nicotine Zonnic nicotine Equaline Nicotine Transdermal System Step 1 Nicoderm Trd 114mg Nicotine/21 Nicorette Mint Nicorelief Nicotine Tartrate Basic Care Nicotine Mini Medline Nictoine Gum Nicotine Transdermal System Step 3 Zonnic Nicotine Polacrilex Nicotine Mini Family Wellness Nicotine Nicorette Invisipatch Humana Pharmacy Nicotine CareOne nicotine Nicotine Transdermal System Step 2 Nicorette Fresh Mint Habitrol Step 3 Healthy Accents Nicotine Nicoderm Trd 36mg Nicotine/7 Sqcm Patch
Indication	For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.
Categories	Agents producing tachycardia Alkaloids Autonomic Agents Cholinergic Agents Cholinergic Agonists Cholinergic Nicotinic Agonist Cytochrome P-450 CYP1A2 Inducers Cytochrome P-450 CYP1A2 Inducers (strength unknown) Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP2A6 Inhibitors Cytochrome P-450 CYP2A6 Inhibitors (strength unknown) Cytochrome P-450 CYP2A6 Substrates Cytochrome P-450 CYP2B6 Substrates Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2C8 Substrates Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP2E1 Inducers Cytochrome P-450 CYP2E1 Inducers (strength unknown) Cytochrome P-450 CYP2E1 Inhibitors Cytochrome P-450 CYP2E1 Inhibitors (strength unknown) Cytochrome P-450 CYP2E1 Substrates Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Drugs Used in Addictive Disorders Drugs Used in Nicotine Dependence Ganglion Blockers Ganglionic Stimulants Miscellaneous Autonomic Drugs Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates Nervous System Neurotransmitter Agents Nicotine, antagonists & inhibitors Nicotinic Agonists OCT1 inhibitors OCT2 Inhibitors Peripheral Nervous System Agents Pyridines Smoking Cessation Agents Solanaceous Alkaloids
ATC-Code	N07BA01
CAS number	54-11-5

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Neuronal acetylcholine receptor subunit alpha-4	MELGGPGAPRLLPPLLLLLGTGLLRASSHVETRAHAEERLLKKLFSGYNK...	unknown	agonist
Neuronal acetylcholine receptor subunit alpha-7	MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQP...	unknown	agonist
Neuronal acetylcholine receptor subunit beta-2	MARRCGPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPAT...	unknown	agonist
Neuronal acetylcholine receptor subunit alpha-2	MGPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALP...	unknown	agonist
Neuronal acetylcholine receptor subunit alpha-3	MGSGPLSLPLALSPPRLLLLLLLSLLPVARASEAEHRLFERLFEDYNEII...	unknown	agonist
Neuronal acetylcholine receptor subunit alpha-5	MAARGSGPRALRLLLLVQLVAGRCGLAGAAGGAQRGLSEPSSIAKHEDSL...	unknown	agonist
Neuronal acetylcholine receptor subunit alpha-6	MLTSKGQGFLHGGLCLWLCVFTPFFKGCVGCATEERLFHKLFSHYNQFIR...	unknown	agonist
Neuronal acetylcholine receptor subunit alpha-9	MNWSHSCISFCWIYFAASRLRAAETADGKYAQKLFNDLFEDYSNALRPVE...	unknown	agonist
Neuronal acetylcholine receptor subunit alpha-10	MGLRSHHLSLGLLLLFLLPAECLGAEGRLALKLFRDLFANYTSALRPVAD...	unknown	agonist
Neuronal acetylcholine receptor subunit beta-3	MLPDFMLVLIVLGIPSSATTGFNSIAENEDALLRHLFQGYQKWVRPVLHS...	unknown	agonist
Neuronal acetylcholine receptor subunit beta-4	MRRAPSLVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSS...	unknown	agonist
Cytochrome P450 19A1	MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGP...	unknown	inhibitor
Choline O-acetyltransferase	MGLRTAKKRGLGGGGKWKREEGGGTRGRREVRPACFLQSGGRGDPGDVGG...	unknown	inhibitor
Cytochrome P450 1A1	MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIG...	unknown	substrate,inducer
Cytochrome P450 1A2	MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPL...	unknown	substrate,inducer
Cytochrome P450 2C19	MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDV...	unknown	substrate
Cytochrome P450 2C8	MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDI...	unknown	substrate
Cytochrome P450 2C9	MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDI...	unknown	substrate
Cytochrome P450 2D6	MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVD...	unknown	substrate
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	substrate
Amine oxidase [flavin-containing] A	MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGG...	unknown	inhibitor
Amine oxidase [flavin-containing] B	MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQK...	unknown	inhibitor
Cytochrome P450 2A6	MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLN...	unknown	substrate,inhibitor
Cytochrome P450 2E1	MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLEL...	unknown	substrate,inhibitor,inducer
Cytochrome P450 2A13	MLASGLLLVTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLN...	unknown	substrate
Cytochrome P450 2B6	MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRG...	unknown	substrate
Solute carrier family 22 member 2	MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHR...	unknown	inhibitor
Solute carrier family 22 member 1	MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHC...	unknown	inhibitor
Solute carrier family 22 member 3	MPSFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYW...	unknown	inhibitor
Solute carrier family 22 member 5	MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRC...	unknown	inhibitor
Solute carrier family 22 member 4	MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRC...	unknown	inhibitor
View More

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682