Norethisterone, also known as norethindrone, is a synthetic progestational hormone belonging to the 19-nortestosterone-derived class of progestins.[A10367] It is further classified as a second-generation progestin, along with [levonorgestrel] and its derivatives, and is the active form of several other progestins including [norethynodrel] and [lynestrenol].[A10367] Norethisterone mimics the actions of endogenous [progesterone], albeit with a greater potency,[A188075] and is used on its own or in combination with estrogen derivatives in a variety of applications including contraception and hormone replacement therapy.[L9527,L10301,L10304,L10307] First derived in 1951 in Mexico City, norethisterone was originally intended for use as a remedy for irregular menstruation and endometriosis, and was not marketed for use as an oral contraceptive until 1962.[L10439]
Norethindrone Acetate and Ethinyl Estradiol and Ferrous Fumarate
Norlutate
Nora BE
Lyleq
Movisse
Necon 1/35
Norethindrone and Ethinyl Estradiol and Ferrous Fumarate
Wymzya Fe
Loestrin 1.5/30
ESTROSTEP Fe
Nortrel 28 Day
Ortho 7/7/7 Tablets (28 Day)
WYMZYA Fe
Deblitane
Gildess 1/20
Norinyl 1/50 21 Tab
Norlyda
Blisovi 24 Fe
Ortho-novum 1/50 Tablets (28 Day)
Estradiol and Norethindrone Acetate
Alyacen 7/7/7
Tarina 24 Fe
Jolivette
Nylia 7/7/7
Larin 1/20
Larin Fe 1.5/30
Jevantique
Indication
Norethisterone is indicated as an oral contraceptive when given as monotherapy[L9527] or in combination with an estrogen component, such as [ethinylestradiol] or [estradiol].[L10313,L10307] In combination with an estrogen component, oral norethisterone is also indicated as a hormone replacement therapy in the treatment of postmenopausal osteoporosis and moderate-to-severe vasomotor symptoms arising from menopause.[L10304] When applied via transdermal patch, the combination of norethisterone and estradiol is indicated for the treatment of hypoestrogenism, vulvovaginal atrophy, and moderate-severe vasomotor symptoms.[L10301] Norethisterone, taken in combination with intramuscular [leuprolide], is also indicated for the symptomatic treatment of endometriosis-related pain.[L10310]
Categories
Adrenal Cortex Hormones
Anti-Gonadotropin-Releasing Hormones
Combination Contraceptives (with Estrogen and derivatives)
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
