NMY

NEOMYCIN

Find entries where: NMY

is present as a standalone ligand in 27 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 3 entries

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Chemical Component Summary
Name	NEOMYCIN
Synonyms	MYCIFRADIN; NEOMAS; PIMAVECORT; VONAMYCIN
Identifiers	(2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxy-oxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxy-cyclohexyl]oxy-oxane-3,4-diol
Formula	C₂₃ H₄₆ N₆ O₁₃
Molecular Weight	614.644
Type	NON-POLYMER
Isomeric SMILES	C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)N)O[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O[C@@H]4[C@@H]([C@H]([C@@H]([C@@H](O4)CN)O)O)N)O)O)N
InChI	InChI=1S/C23H46N6O13/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22/h5-23,30-36H,1-4,24-29H2/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1
InChIKey	PGBHMTALBVVCIT-VCIWKGPPSA-N

Chemical Details
Formal Charge	0
Atom Count	88
Chiral Atom Count	19
Bond Count	91
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB00452 ?
Name	Framycetin
Groups	approved
Description	A component of neomycin that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed)
Synonyms	Framicetina Framycetin Framycetinum Neomycin B Framycetin sulfate Framycétine Fradiomycin B
Brand Names	Sandoz Opticort Proctol Suppositories Sofracort Sterile Ear/eye Ointment Soframycin Nasal Spray Soframycin Sterile Eye Ointment 0.5% Odan Proctomyxin HC Suppositories Sofracort Proctol Ointment Soframycin Eye Ont 0.5% Soframycin Eye Drops Odan Proctomyxin HC Soframycin Sterile Eye Ointment Teva-proctosone Sofra Tulle Strip (10 X 30cm) Sofracort Ear/eye Ointment Proctosedyl Ointment Soframycin Eye Drops 5mg/ml Sofracort Sterile Ear/eye Drops Proctosedyl Sup Soframycin Ointment Soframycin Skin Ointment Proctosedyl Sofra-tulle Sofracort Eye/ear Drops Sofra Tulle 10 X 10cm Proctosedyl Suppositories Soframycin Eye Drops 0.5%
Indication	For the treatment of bacterial blepharitis, bacterial bonjunctivitis, corneal injuries, corneal ulcers and meibomianitis. For the prophylaxis of ocular infections following foreign body removal
Categories	Agents that produce neuromuscular block (indirect) Aminoglycoside Antibacterials Anti-Bacterial Agents Anti-Infective Agents Carbohydrates Dermatologicals Glycosides Medicated Dressings Medicated Dressings With Antiinfectives Nasal Preparations Nephrotoxic agents Ophthalmologicals Sensory Organs
ATC-Code	D09AA01 R01AX08 S01AA07
CAS number	119-04-0

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
16S ribosomal RNA	-	unknown	inhibitor
30S ribosomal protein S12	MATVNQLVRKPRARKVAKSNVPALEACPQKRGVCTRVYTTTPKKPNSALR...	unknown	inhibitor
C-X-C chemokine receptor type 4	MEGISIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIFL...	unknown	antagonist

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682