ORO
OROTIC ACID
Find entries where: ORO
is present as a standalone ligand in 150 entries
as a non-polymer is covalently linked to polymer or other heterogen groups 2 entries
Chemical Component Summary | |
|---|---|
| Name | OROTIC ACID |
| Identifiers | 2,6-dioxo-3H-pyrimidine-4-carboxylic acid |
| Formula | C5 H4 N2 O4 |
| Molecular Weight | 156.096 |
| Type | NON-POLYMER |
| Isomeric SMILES | C1=C(NC(=O)NC1=O)C(=O)O |
| InChI | InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11) |
| InChIKey | PXQPEWDEAKTCGB-UHFFFAOYSA-N |
Chemical Details | |
|---|---|
| Formal Charge | 0 |
| Atom Count | 15 |
| Chiral Atom Count | 0 |
| Bond Count | 15 |
| Aromatic Bond Count | 6 |
Drug Info: DrugBank
| DrugBank ID | DB02262? |
|---|---|
| Name | Orotic acid |
| Groups | investigational |
| Synonyms |
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| Categories |
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| CAS number | 65-86-1 |
Drug Targets
| Name | Target Sequence | Pharmacological Action | Actions |
|---|---|---|---|
| Orotate phosphoribosyltransferase | MKPYQRQFIEFALNKQVLKFGEFTLKSGRKSPYFFNAGLFNTGRDLALLG... | unknown | |
| Dihydroorotate dehydrogenase (quinone), mitochondrial | MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLD... | unknown | |
| Dihydroorotate dehydrogenase (quinone) | MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCM... | unknown | |
| Dihydroorotase | MTAPSQVLKIRRPDDWHLHLRDGDMLKTVVPYTSEIYGRAIVMPNLAPPV... | unknown | inhibitor |
| Dihydroorotate dehydrogenase A (fumarate) | MLNTTFANAKFANPFMNASGVHCMTIEDLEELKASQAGAYITKSSTLEKR... | unknown |
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
Related Resource References
| Resource Name | Reference |
|---|---|
| PubChem | 967, 5280334 |
| ChEMBL | CHEMBL1235017 |
| ChEBI | CHEBI:16742 |
| CCDC/CSD | XARBEZ, LIDCAE02, LIDCAE, LIDCAE01, OROTAC01, OROTAC02, OROTAC, XARBID, XARBOJ, VEYLOD |
| COD | 2018388, 2217954 |
