PHE

PHENYLALANINE

Find entries where: PHE

is present as a standalone ligand in 107 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 63 entries

is present in a polymer sequence 218,666 entries

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Chemical Component Summary
Name	PHENYLALANINE
Identifiers	(2S)-2-amino-3-phenyl-propanoic acid
Formula	C₉ H₁₁ N O₂
Molecular Weight	165.189
Type	L-PEPTIDE LINKING
Isomeric SMILES	c1ccc(cc1)C[C@@H](C(=O)O)N
InChI	InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1
InChIKey	COLNVLDHVKWLRT-QMMMGPOBSA-N

Chemical Details
Formal Charge	0
Atom Count	23
Chiral Atom Count	1
Bond Count	23
Aromatic Bond Count	6

Drug Info: DrugBank

DrugBank ID	DB00120 ?
Name	Phenylalanine
Groups	approved nutraceutical investigational
Description	Phenylalanine is an essential aromatic amino acid that is a precursor of melanin, [dopamine], [noradrenalin] (norepinephrine), and [thyroxine].
Synonyms	(S)-2-Amino-3-phenylpropionic acid Phenylalanine hydrochloride Phenylalanine sodium Phenylalaninum 3-phenyl-L-alanine β-phenyl-L-alanine Phe F Fenilalanina beta-Phenyl-L-alanine L-Phenylalanine (S)-alpha-Amino-beta-phenylpropionic acid Phenylalanine
Brand Names	Olimel 5.7% 20% Prosol Essepna 8.5% Freamine III Aminosyn 10% W Electrolytes Aminosyn II 10% With Electrolytes Aminosyn 5% Aminosyn II in Dextrose Aminosyn II 7% Injection Olimel 7.6% E ProSol Travasol Amino Acid Inj 5.5% Travasol Inj Without Electrolytes 5.5% Aminosyn II 7% M In 10% Dextrose(dual Chamber) 4.25% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Aminosyn II 8.5% With 50% Dextrose Kabiven 2.5% Travasol Amino Acid Injection Without Electrolytes In 10% Dextrose Quickmix Vamin N FreAmine HBC Perikabiven Nephramine Liq IV Aminosyn II and Dextrose 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose HepatAmine Aminosyn II 7% With 50% Dextrose 2.75% Travas. Amino Acid InJ.W.elecw.25%dex ProcalAmine Aminosyn II 8.5% Injection FreAmine III Olimel 4.4% Clinimix Aminosyn II 5% Inj Clinimix E Olimel 7.6% 2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Aminosyn 3.5% M Aminosyn-PF 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Aminosyn II Aminosyn II with Electrolytes Aminosyn NephrAmine Hepatasol Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) Synthamin Plenamine Aminosyn II with Electrolytes in Dextrose with Calcium Smofkabiven Extra Nitrogen Electrolyte Free 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. 4.25%travasol Amino Acid InJ.W.elecw.5%dex. Aminosyn Sulfite Free Clinisol Vamin 18 Electrolyte-free Travasol Inj Without Electrolytes 8.5% Premasol - sulfite-free (Amino Acid) Olimel 4.4% E Primene 10%-liq IV Aminosyn-PF 10% Primene Novamine 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix Periolimel 2.5% E 4.25% Amino Acid Injection Without Electrolytes In 20% Dextrose Quickmix Aminosyn 8.5% Aminosyn RF Injection 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Travasol Amino Acid Inj 8.5% 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Travasol Nutrineal Pd4 Olimel 3.3% E Aminosyn-PF 7% Quick Mix 2.5% Travasol Aa With Electrolytes With 25% Dextrose Injec 4.25% Travasol Amino Acid Without Electrolytes In 5% Dextrose Quickmix 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Aminosyn HF Aminosyn 7% 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Olimel 5.7% E Smofkabiven Aminosyn II In Dextrose Injection 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Aminosyn 8.5% Injection With Electrolytes 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Smofkabiven Electrolyte Free 2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Quickmix 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Quickmix Smofkabiven Extra Nitrogen Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. Primene 10% Travasol E Renamin (amino Acids) Injection Aminosyn II 7% With 10% Dextrose Aminosyn RF TrophAmine Smofkabiven Peripheral 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose RenAmin
Indication	L-phenylalanine may be helpful in some with depression. It may also be useful in the treatment of vitiligo. There is some evidence that L-phenylalanine may exacerbate tardive dyskinesia in some schizophrenic patients and in some who have used neuroleptic drugs.
Categories	Amino Acids Amino Acids, Aromatic Amino Acids, Cyclic Amino Acids, Essential Amino Acids, Peptides, and Proteins Dietary Supplements Immunosuppressive Agents Myelosuppressive Agents Proteinogenic Amino Acids Supplements
CAS number	63-91-2

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Tyrosine aminotransferase	MDPYMIQMSSKGNLPSILDVHVNVGGRSSVPGKMKGRKARWSVRPSDMAK...	unknown
Large neutral amino acids transporter small subunit 2	MEEGARHRNNTEKKHPGGGESDASPEAGSGGGGVALKKEIGLVSACGIIV...	unknown
Phenylalanine--tRNA ligase alpha subunit	MADGQVAELLLRRLEASDGGLDSAELAAELGMEHQAVVGAVKSLQALGEV...	unknown
Phenylalanine-4-hydroxylase	MSTAVLENPGLGRKLSDFGQETSYIEDNCNQNGAISLIFSLKEEVGALAK...	unknown
Phenylalanine--tRNA ligase, mitochondrial	MVGSALRRGAHAYVYLVSKASHISRGHQHQAWGSRPPAAECATQRAPGSV...	unknown
Phenylalanine--tRNA ligase beta subunit	MPTVSVKRDLLFQALGRTYTDEEFDELCFEFGLELDEITSEKEIISKEQG...	unknown
Tyrosine 3-monooxygenase	MPTPDATTPQAKGFRRAVSELDAKQAEAIMVRGQGAPGPSLTGSPWPGTA...	unknown	binder
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
PubChem	6925665, 6140
ChEMBL	CHEMBL301523
ChEBI	CHEBI:58095, CHEBI:17295
CCDC/CSD	EDAXIQ02, EDAXIQ05, EDAXIQ06, QURQUP, EDAXIQ, NONZUL, EDAXIQ03, OJEPEY, BEZPAZ, IREKAR, PAXXUJ, RALRUS, GUQCAY, JOTKIM01, VAGVIJ, REPFUN, HUHSOS, JOTKIM, LAGDIG, CADLOK, FETNEY, CADLOK01, NALYEH, YAMVIS, MIFRIC, JAXZIS, IZAQUV, PHALNC01, EQUYEX
COD	2202945, 2200004, 4517356

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

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PHE

PHENYLALANINE

Chemical Component Summary

Chemical Details

Drug Info: DrugBank

Drug Targets

Related Resource References