POD

9-HYDROXY-5-(3,4,5-TRIMETHOXYPHENYL)-5,8,8A,9-TETRAHYDROFURO[3',4':6,7]NAPHTHO[2,3-D][1,3]DIOXOL-6(5AH)-ONE

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is present as a standalone ligand in 1 entries

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Chemical Component Summary
Name	9-HYDROXY-5-(3,4,5-TRIMETHOXYPHENYL)-5,8,8A,9-TETRAHYDROFURO[3',4':6,7]NAPHTHO[2,3-D][1,3]DIOXOL-6(5AH)-ONE
Synonyms	PODOPHYLLOTOXIN
Identifiers	n/a
Formula	C₂₂ H₂₂ O₈
Molecular Weight	414.405
Type	NON-POLYMER
Isomeric SMILES	COc1cc(cc(c1OC)OC)[C@@H]2c3cc4c(cc3[C@@H]([C@@H]5C2C(=O)OC5)O)OCO4
InChI	InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19-,20-/m0/s1
InChIKey	YJGVMLPVUAXIQN-XVVDYKMHSA-N

Chemical Details
Formal Charge	0
Atom Count	52
Chiral Atom Count	4
Bond Count	56
Aromatic Bond Count	12

Drug Info: DrugBank

DrugBank ID	DB01179 ?
Name	Podofilox
Groups	approved
Description	A lignan found in podophyllin resin from the roots of podophyllum plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.
Synonyms	Podofilox (?)-podophyllotoxin PPT Podophyllotoxin Podophyllinic acid lactone
Brand Names	Condyline Condylox Podofilox Wartec Condylox (podofilox)Topical Solution 0.5%
Indication	For treatment of external genital warts (<i>Condyloma acuminatum</i>).
Categories	Antimitotic Agents Antineoplastic Agents, Phytogenic Antiviral Agents Benzene Derivatives Benzyl Compounds Decreased Mitosis Dermatologicals Keratolytic Agents Lignans Misc. Skin and Mucous Membrane Agents Mitosis Modulators Naphthalenes Tetrahydronaphthalenes Tubulin Modulators
ATC-Code	D06BB04
CAS number	518-28-5

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Tubulin alpha-4A chain	MRECISVHVGQAGVQMGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFT...	unknown	inhibitor
Tubulin beta chain	MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLDRISVY...	unknown	inhibitor
DNA topoisomerase 2-alpha	MEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTY...	unknown	inhibitor

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682