PPI
PROPANOIC ACID
Find entries where: PPI
is present as a standalone ligand in 54 entries
as a non-polymer is covalently linked to polymer or other heterogen groups 2 entries
is present in a polymer sequence 4 entries
Chemical Component Summary | |
|---|---|
| Name | PROPANOIC ACID |
| Identifiers | propanoic acid |
| Formula | C3 H6 O2 |
| Molecular Weight | 74.079 |
| Type | NON-POLYMER |
| Isomeric SMILES | CCC(=O)O |
| InChI | InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5) |
| InChIKey | XBDQKXXYIPTUBI-UHFFFAOYSA-N |
Chemical Details | |
|---|---|
| Formal Charge | 0 |
| Atom Count | 11 |
| Chiral Atom Count | 0 |
| Bond Count | 10 |
| Aromatic Bond Count | 0 |
Drug Info: DrugBank
| DrugBank ID | DB03766? |
|---|---|
| Name | Propanoic acid |
| Groups |
|
| Description | Sodium propionate is the sodium salt of propionic acid that exists as colorless, transparent crystals or a granular crystalline powder. It is considered generally recognized as safe (GRAS) food ingredient by FDA, where it acts as an antimicrobial agent for food preservation and flavoring agent. Its use as a food additive is also approved in Europe. Sodium propionate is is prepared by neutralizing propionic acid with sodium hydroxide. Sodium propionate was previously approved in Canada as an active ingredient in Amino-Cerv (used to treat inflammation or injury of the cervix). |
| Synonyms |
|
| Brand Names | Amino-cerv |
| Indication | Propanoic acid and various direct sodium or calcium salt formulations of the acid are currently most commonly approved and indicated by organizations like the FDA and EMA for use as an antibacterial food additive preservative in animal feed and food for human consumption [L2715, L2716]. Similarly, although the use of propanoic acid or any of its direct sodium or calcium salt formulations as excipient ingredients in pharmaceuticals is not necessarily a major role for the compound today, sodium propionate was used in some vaginal cream preparations indicated for cervicitis, cervical tears, and/or postcauterization, postcryosurgery, and postconization of the cervix [T193]. In such products, the sodium propionate was primarily used to elicit a preservative, bacteriostatic [L2710, F50] effect while other active ingredients combined in the formulation like urea, benzalkonium chloride, inositol, and methionine and cystine amino acids facilitated debridement, enhanced medication spread, epithelialization promotion, and wound healing, respectively [L2710, A32973]. Nevertheless, a great variety of propionic acid derivatives exist as separate pharmaceuticals, each with their own unique therapeutic categories, pharmacodynamics, and pharmacokinetics. |
| Categories |
|
| ATC-Code | S01AX10 |
| CAS number | 79-09-4 |
Drug Targets
| Name | Target Sequence | Pharmacological Action | Actions |
|---|---|---|---|
| Alanine racemase | MNDFHRDTWAEVDLDAIYDNVENLRRLLPDDTHIMAVVKANAYGHGDVQV... | unknown | |
| Gephyrin | MATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLG... | unknown | |
| 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase | MANLEIGKSILAAGVLTNYHDVGEGQPVILIHGSGPGVSAYANWRLTIPA... | unknown | |
| Histone deacetylase | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRK... | unknown | inhibitor |
| Fatty acid-binding protein, adipocyte | MCDAFVGTWKLVSSENFDDYMKEVGVGFATRKVAGMAKPNMIISVNGDVI... | unknown |
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
Related Resource References
| Resource Name | Reference |
|---|---|
| PubChem | 1032 |
| ChEMBL | CHEMBL14021 |
| ChEBI | CHEBI:30768 |
| CCDC/CSD | VOJFEF, UYIPUP, UYIQIE, QEQSIR, BOPBIS, ZUQJUT, FIVJAY, XICWUD, VEVLIR, NARVUX, EQOPOP, KIJLOG, VEVLIR01, SAGQEW, YEMVIW, BIJVUL, MORMIP01, LUNYIC, PRONAC02, HANBOO, BEGZAP, YINJOU |
| COD | 7103922 |
