PRP

1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose

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is present as a standalone ligand in 87 entries

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Chemical Component Summary
Name	1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose
Synonyms	ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID; 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribose; 1-O-pyrophosphono-5-O-phosphono-D-ribose; 1-O-pyrophosphono-5-O-phosphono-ribose
Identifiers	[(2R,3R,4S,5R)-3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl] phosphono hydrogen phosphate
Formula	C₅ H₁₃ O₁₄ P₃
Molecular Weight	390.07
Type	D-SACCHARIDE
Isomeric SMILES	C([C@@H]1[C@H]([C@H]([C@H](O1)O[P@@](=O)(O)OP(=O)(O)O)O)O)OP(=O)(O)O
InChI	InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/t2-,3-,4-,5-/m1/s1
InChIKey	PQGCEDQWHSBAJP-TXICZTDVSA-N

Chemical Details
Formal Charge	0
Atom Count	35
Chiral Atom Count	5
Bond Count	35
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB01632 ?
Name	5-O-phosphono-alpha-D-ribofuranosyl diphosphate
Groups	approved investigational experimental
Description	The key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides.
Synonyms	5-O-phosphono-alpha-D-ribofuranosyl diphosphate Phosphoribosyl pyrophosphate PRib-PP α-D-ribofuranose 5-(dihydrogen phosphate) 1-(trihydrogen diphosphate) 5-Phosphoribosyl diphosphate 5-O-phosphono-α-D-ribofuranosyl diphosphate PRPP 5-Phospho-alpha-D-ribose 1-diphosphate 5-Phosphoribosyl 1-pyrophosphate Phosphoribosylpyrophosphate
Categories	Carbohydrates Pentosephosphates Sugar Phosphates
CAS number	13270-65-0

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Hypoxanthine-guanine phosphoribosyltransferase	MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLA...	unknown
Orotate phosphoribosyltransferase	MKPYQRQFIEFALNKQVLKFGEFTLKSGRKSPYFFNAGLFNTGRDLALLG...	unknown	substrate
Uridine-cytidine kinase-like 1	MAAPPARADADPSPTSPPTARDTPGRQAEKSETACEDRSNAESLDRLLPP...	unknown
Hypoxanthine-guanine phosphoribosyltransferase	MPREYEFAEKILFTEEEIRTRIMEVAKRIADDYKGKGLRPYVNPLVLISV...	unknown
Adenine phosphoribosyltransferase	MADSELQLVEQRIRSFPDFPTPGVVFRDISPVLKDPASFRAAIGLLARHL...	unknown
Anthranilate phosphoribosyltransferase	MQATLIKPTIFTHQPILEKLFKSQSMTQEESHQLFAAIVRGELEDSQLAA...	unknown
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682