PX9

Pramocaine

Created:	2015-02-06
Last modified:	2015-07-01

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6 entries where PX9 is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	48
Chiral Atom Count	0
Bond Count	49
Aromatic Bond Count	6

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Chemical Component Summary
Name	Pramocaine
Systematic Name (OpenEye OEToolkits)	4-[3-(4-butoxyphenoxy)propyl]morpholine
Formula	C₁₇ H₂₇ N O₃
Molecular Weight	293.401
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	12.01	O(c2ccc(OCCCN1CCOCC1)cc2)CCCC
SMILES	CACTVS	3.385	CCCCOc1ccc(OCCCN2CCOCC2)cc1
SMILES	OpenEye OEToolkits	1.9.2	CCCCOc1ccc(cc1)OCCCN2CCOCC2
Canonical SMILES	CACTVS	3.385	CCCCOc1ccc(OCCCN2CCOCC2)cc1
Canonical SMILES	OpenEye OEToolkits	1.9.2	CCCCOc1ccc(cc1)OCCCN2CCOCC2
InChI	InChI	1.03	InChI=1S/C17H27NO3/c1-2-3-12-20-16-5-7-17(8-6-16)21-13-4-9-18-10-14-19-15-11-18/h5-8H,2-4,9-15H2,1H3
InChIKey	InChI	1.03	DQKXQSGTHWVTAD-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank ID	DB09345 ?
Name	Pramocaine
Groups	approved
Description	Pramocaine (also known as pramoxine or pramoxine HCI) is a topical anesthetic and antipruritic. It is used for many dermatological and anorectal/anogenital conditions including minor cuts/burns, insect bites, hives/rashes due to poison ivy exposure, hemorrhoids and other anorectal/anogenital disorders. Pramocaine is available by itself and in combination with other medications in various topical preparations. It works by preventing ionic fluctuations needed for neuron membrane depolarization and action potential propagation.
Synonyms	Pramoxine Pramocaína Pramocaine Pramoxine hydrochloride
Brand Names	Double Antibiotic Plus Pain Relief Maximum Strength Signature Care Hemorrhoidal CVS Anti-Itch Shopko Triple Antibiotic Plus Equate Antibiotic Plus Pain Relief Calamine Clear Itch Relief Balm Ivy Wash Family Wellness Plus Pain Relief Cocoskin Itch-X Triple Antibiotic Itch X Hemorrhoidal Maximum Strength Pain Relief Calamine Plus Pramoxine HCl Analpram HC Antibiotic, Pain and Scar Hydrocortisone Acetate Pramoxine HCl Triple Antibiotic and Burn Relief Quality Choice Anti-Itch Clear First Aid Antibiotic OLP Triple Antibiotic Plus Johnson and Johnson All Purpose First Aid Kit First Aid Antibiotic Plus Pain Relief Maximum Strength Natureplex Antibiotic Plus Pain, Itch, Scar Relief Gold Bond Intensive Healing Anti Itch Skin Protectant Walgreens Kids Multi-Antibiotic with Pain Relief Cream Up and Up Hemorrhoidal Itch X Gel Band Aid Antiseptic Cleansing Freds Medicated anti itch Antibiotic Plus Pain Relief meijer Antibiotic Plus Pain Relief Hemorrhoidal Anesthetic Proctodan-HC Ointment Oncoderm ItchRx Triple antibiotic and pain relief Avedana Hemorrhoidal Maximum Strength Western Family Triple Antibiotic plus Pain Relief TheraCare Triple Antibiotic Pain Relief Atopalm First Aid Triple Antibiotic plus Pain Relief Good Sense Triple Antibiotic DDM Calaclear Galentic Triple Antibiotic Plus Pain Relief Proctofoam NS Best Choice Anti-Itch Clear Anti Itch Maximum Relief Pramoxine-HC Multi Antibiotic with Pain Relief Maximum Strength Sheffield Triple Antibiotic Plus Pain Relief Gold Bond Anti Itch W15883-CS Vida Mia Calaclear Anuzinc HC Plus Dermagesic Pain Relief Equaline First Aid Antibiotic GNP Caldyphen Select Brand Hemorrhoid Signature Care First Aid Antibiotic Anti-Itch Soothing Wipes 1 Pramoxine Hydrochloride Signature Care Triple Antibiotic Acella Hydrocortisone Acetate - Pramoxine Singles Family Care Triple Antibiotic Plus Pain Relief Triple Antibiotic plus pain relief Pramoxine hydrochloride CeraVe Itch Relief Moisturizing Hemorrhoidal Ointment Triple Antibiotic with Pain Relief Maximum Strength Walgreens Maximum Strength Triple Antibiotic With Pain Relief First Aid Antiseptic Pain Relieving Neosporin Plus Pain Relief Neo to Go Triple Antibiotic with Pain Relief Caladryl Good Neighbor Pharmacy Triple Antibiotic Plus Pain Relief Aveeno Active Naturals Skin Relief Medicated Anti Itch Treatment Itch Relief Lotion First Aid Clear Anti-Itch medicated pads Rite Aid Bikini Zone MEDICATED After Shave Fresh Scent Caldyphen Clear First Aid Antibiotic plus Burn Relief Pramox HC Lotion Aveeno Anti-itch Lotion Neosporin Plus Pain Relief Neo To Go First Aid Antibiotic Pain Relieving Premier Value Calaclear Antibiotic and pain relief maximum strength Honey Pot Hydrocortisone Acetate and Pramoxine Hydrochloride Pramox HC Cream Family Wellness Triple Antibiotic Plus Pain Relief Triple Antibiotic and Pain Relief Maximum Strength Pramosone E Cream 2.5% hydrocortisone acetate 2.5% pramoxine hydrochloride 1% Leader Triple Antibiotic and Pain Relief Triple Antibiotic Plus Live Better Triple Antibiotic plus Pain Relief Preferred Plus Hemorrhoid Tripleantibioticapainscaritch Leader Triple antibiotic and pain relief Natureplex Hemorrhoidal Neosporin Plus Pain Relief Neo To Go First Aid Antiseptic Pain Relieving Dr. Sheffield Hemorrhoid Aveeno Calamine and Pramoxine Hydrochloride Anti Itch CAREONE Antibiotic Plus Pain Relief Sarna DDM Calagesic Up and Up multi action antibiotic Equaline Antibiotic Plus Pain Relief for Kids Publix antibiotic plus Pain Relief Equaline Hemorrhoidal Anti-Itch Rite Aid Pharmacy Antibiotic With Pain Relief Anti-Itch Wipes Shoprite Triple Antibiotic LiveBetter Antibiotic Plus Pain Relief Shopko Triple Antibiotic plus Pain Relief CVS Medicated Anti-Itch Soothing Care Itch Relief Spray Hydrocortisone Acetate 2.5% Pramoxine HCl 1% Proctodan-HC Suppositories Hemorrhoidal Cream with Aloe Safeway Antibiotic Plus Pain Relief Scalpicin Medicated Wipes Family Wellness Pain Scar Itch Family Wellness Antiseptic and Pain Relief Blistex Ivarest Poison Ivy Itch Calamine Plus Pramoxine HCL MEDICATED ANTI-ITCH Well at Walgreens Antibiotic CeraVe Itch Relief Moisturizing Cream Exchange Select First Aid Triple Anitbiotic Pain Relieving Neosporin Plus Pain Relief Anodan-plus Ointment hydrocortisone acetate pramoxine HCl Anesthetic Hemorrhoidal With Aloe Select Brand Anti-Itch Fleet Itch Relief Moisturizing Lotion Aveeno Restorative Skin Therapy Itch Relief Balm CVS Pharmacy Maximum Strength Feminine Wipes Poison Ivy Wash Equate Antibiotic Plus Pain, Itch, Scar Relief DerMend Moisturizing Anti-Itch Humco Calagesic Neosporin Plus Pain Relief Neo To Go First Aid Antiseptic Pain Relieving For Kids Healthy Accents Triple Antibiotic LEADER Caldyphen Clear PrameGel Rexall Maximum Strength Hemorrhoidal TopCare Calaclear Analpram E Cream 2.5% Kit hydrocortisone acetate 2.5% pramoxine hydrochloride 1% Pentrexcilina Triple Antibiotic Plus Pain Relief Calamine Neosporin Kids Plus Pain Relief Basic Care First Aid Antibiotic Plus Pain Relief First Aid Antibiotic Bacitraycin Plus Maximum Strength Cortane-B CVS Health Maximum Strength Feminine Cuadriderma Natureplex Antibiotic plus Pain SIMPLE PROMISE Simple H Hemorrhoid Relief Cream Anuzinc Plus Suppositories Bacitraycin MAX Pain Relief TopCare Antibiotic Plus Pain Relief Equate First Aid Antibiotic Plus Pain Relief Anugesic-HC Suppositories Polysporin Itch Relief Sunmark Caldiphen Aveeno Anti-Itch Concentrated Sandoz Anuzinc HC Plus Triple antibiotic and pain itch scar First Degree Maximum Strength Burn Tucks Fast Relief CareALL Triple Antibiotic plus Pain Relief Cortaine -B Aqueous Antibiotic plus Pain Relief Bikini Zone Medicated After Shave Spray Triple Antibiotic Plus Pain Relief Sunmark Caldyphen Clear Itch-X Gel Calaclear First Aid Sensitive Anti-Itch Glycerin, Phenylephrine Hydrochloride, Pramoxine, White Petrolatum Hemorrhoidal Relief Aveeno Calm Plus Restore Itch Relief Balm Antibiotic and Pain Relief Maximum Strength proctofoam HC Polysporin Lip Treatment Humco Calaclear Sandoz Anuzinc Plus Polysporin Poly To Go Topcare Antibiotic Hydro Ear Eczemin Itch Relief Clear Skin Protectant CVS Neosporin Plus Pain Relief Clubtray Pomada De La Campana Triple Antibiotic Pain Relief Sally Hansen Zero bump bikini Blistex Cold and Allergy Lip Soother CVS Calamine Plus Epifoam Leader Calamine Plus Vagisil Medicated Wipes Good Sense Hemorrhoidal Maximum Strength Pain Relief Reeses Pinworm Itch Relief H E Buddy Antibiotic Maximum Strength Plus Pain Relief Itch Relief Medicated Pads CVS Premier Value Triple Antibiotic Plus Rugby Caldyphen Clear TopCare Calagesic AVON HeXashield Triple Antibiotic with Pain Relief Leader Triple Antibiotic Plus Up and Up Antibiotic Plus Pain Relief Basic Care First Aid Antibiotic Antibiotic Plus Pain Relief Maximum Strength Mineral Oil, Pramoxine Hydrochloride and Zinc Oxide Proctofoam HC ATOPALM Hemorrhoidal Pain Relieving Hemorrhoidal Pain Relief Pramosone Cream Clear Anti Itch Hydrocortisone Acetate Pramoxine Hcl Rexall Hemorrhoidal Dual Action Cream Oticin HC Ear Drops Hydrocortisone Acetate Pramoxine Hydrochloride Hemorrhoid Ointment Hemorrhoidal Gold Bond Anti-itch Lotion Quality Choice Triple Antibiotic Plus Pain Reliever Bactine Pain Relieving Cleansing Spray Bite and Itch No More Bumps Basic Care First Aid Antibiotic and Burn Relief Pramoxine Itch relief Walgreens Maximum Strength Hemorrhoidal Clear Itch Relief Evora Labs Atopalm First Aid Triple Antibiotic Protection Moisturizing and Pain Relief Itch Relief Moisturizing Cream Johnson and Johnson First Aid Travel Ready 80 CT First Aid Maximum Strength Bacitraycin Plus Fissurene Best Choice Medicated Calamine Dg Health Triple Antibiotic Bacitraycin Plus Publix antibiotic plus pain relief Tripleantibioticointmentandpainrelief Clear Anti-Itch Triple Antibiotic plus Pain Relief Maximum Strength NEOSPORIN Plus BURN RELIEF Walgreen Anti-Itch Family Wellness QC Medicated anti itch Tronothane Pramoxine HCl Crm 1% USP Prax Equate Hemorrhoidal Tucks Hemorrhoidal Neosporin Pain Itch Scar Walgreens Multi-Antibiotic with Pain Relief Cream Anusol Plus Suppositories Dermarest Eczema Medicated Moist for Sensitive Skin Oto End 10 Publix Clear Anti-Itch CVS Maximum Strength Feminine Anti-Itch Wipes Premier Value Max Strength Antibiotic plus pain relief DG Health Medicated Anti-Itch Analgesic meijer Triple Antibiotic plus Pain Relief Neosporin Plus Pain Relief First Aid Antibiotic/Pain Relieving Triple Antibiotic Plus Maximum Strength Caladryl Clear Analpram Advanced Childrens Double Antibiotic with Pain Relief Smart Sense antibiotic plus pain relief Topcare Triple Antibiotic Equaline Antibiotic Plus Pain Relief Anugesic-HC Ointment Hemorrhoidal Ointment With Anesthetic for Extra Pain Relief Equate First Aid Antibiotic Pain Relieving Sunmark Antibiotic Plus Pain Relief Harris Teetter Calagesic PREPARATION H Maximum Strength Meijer Triple Antibiotic Plus Bikini Zone Medicated After-shave Roll-ON Relief Publix Calamine Medicated HC Pram Smart Sense Triple Antibiotic Harris Teeter Triple Antibiotic Plus Pain Relief Meijer Antibiotic Plus Pain Relief Smart Sense triple antibitotic plus pain relief Ear Itch MD First Aid Triple Antibiotic and Pain Relief Maximum Strength Shopko Antibiotic Plus Pain Relief Luvena Feminine Wipes Clear Anti-itch Lotion Quality Choice Maximum Strength Triple Antibiotic Rite Aid Cala Itch Relief Welly Bravery First Aid Kit Care One Maximum Strength First Aid Antibiotic Leader Poison Ivy Wash Pramcort Curasore DCH Calaspray Itch Relief Proctofoam-HC Neosporin Plus Pain Relief First Aid Antibiotic Pain Relieving For Kids Best Choice Medicated anti itch Johnson and Johnson First Aid All Purpose 160 CT Dr Bells Pomade Skin Relief Medicated Anti-itch Treatment CVS Pharmacy CVS Medicated anti itch Prosoria Anti-Itch Moisturizer Leader Penimixcina Sarna Sensitive Anti-itch Lotion Hemorrhoidal Cream TopCare Triple Antibiotic Plus Pain Relief Curad Maximum Strength Triple Antibiotic Multi Action CeraVe Developed with Dermatologists Itch Relief Moisturizing Extra Strength Bacitraycin Plus Drs. Pharmacy Triple Antibiotic Plus Gold Bond Medicated Anti-itch Cream Dermoplast Poison Ivy Treatment Careone Triple Antibiotic CVS Itch Relief Analpram E Novacort Gold Bond Intensive Relief Anti-Itch Premier Value Antibiotic Plus Pain Relief Procort LOLA Vaginal Itch Relief Wipes Equaline Triple Antibiotic Rite Aid Soothing Medicated Anit-Itch NATUREPLEX ANTIBIOTIC plus PAIN RELIEF Clear Itch Relief Pramosone Topcare Hemorrhoidal Triple Antibiotic Plus Pain Relief Maximum Strength WinCo Maximum Strength Triple Antibiotic Western Family Antibiotic Plus Pain Relief Sunmark Hemorrhoidal Pramosone E Antibiotic and Pain Relief Smart Sense Antibiotic Maximum Strength First Aid Triple Antibiotic Pain and Scar Oti Rx Anti Itch Soothing 1 Pramoxine Hydrochloride CVS Fragrance Free Anti-Itch First Aid Antibiotic and Pain Relief CVS Hemorrhoidal Bi-Mart Triple Antibiotic plus Pain Relief Oticin DG Health Antibiotic Pro-relief Good Sense Triple Antibiotic and Pain Relief Family Care Maximum Strength Medicated Anti Itch ZyPram Tronolane Preparation H Totables Pain Relief Equaline Triple Antibiotic Plus HEB Calagesic L-Topical CALAMINE 8% PRAMOXINE HCL 1% Proctofoam Sunmark Triple Antibiotic Plus Pain Relief LEADER Caldyphen Band Aid Antiseptic Cleansing To Go VAGISIL Anti-Itch Medicated Wipes Maximum Strength Signature Care Hemorrhoidal Cream (with applicator) HEB Calaclear CVS Health Triple Antibiotic with Pain Relief HEB Maximum Strength Pain Relief Hemorrhoidal First On Topical Analgesic Calamine Plus Private Label Poison Ivy Wash Pramoxine Hydrochloride Up and Up First Aid Antibiotic Pain Relieving Prax Wipe Aveeno Anti Itch Concentrated Anodan-plus Quality Choice Anti-itch Medicated MAXIMUM STRENGTH MEDICATED ANTI-ITCH Rite Aid Welly Bravery Triple Antibiotic with Pain Relief Sarna P Select Brand Calaclear Anusol Plus Ointment Premier Value Calagesic Triple Antibiotic and Pain Relief CVS Health Hemorrhoidal Cream Good Neighbor Pharmacy Antibiotic and Pain Relief GoodSense Antibiotic plus Pain Relief Nikzon Hemorrhoidal
Indication	It is indicated for temporary relief of pain and pruritus from minor lip and skin irritations as well as for temporary relief from pain, burning, itching and discomfort associated with hemorrhoids and other anorectal/anogenital disorders.
Categories	Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use Anesthetics Anesthetics for Topical Use Anesthetics, Local Antipruritics and Local Anesthetics Antipruritics, Incl. Antihistamines, Anesthetics, Etc. Central Nervous System Agents Central Nervous System Depressants Dermatologicals Oxazines Peripheral Nervous System Agents Sensory System Agents Vasoprotectives
ATC-Code	D04AB07 C05AD07
CAS number	140-65-8

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Voltage-gated sodium channel alpha subunit	MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPK...	unknown	blocker

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682