RIS

1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID

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is present as a standalone ligand in 19 entries

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Chemical Component Summary
Name	1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID
Synonyms	Risedronate
Identifiers	(1-hydroxy-1-phosphono-2-pyridin-3-yl-ethyl)phosphonic acid
Formula	C₇ H₁₁ N O₇ P₂
Molecular Weight	283.112
Type	NON-POLYMER
Isomeric SMILES	c1cc(cnc1)CC(O)(P(=O)(O)O)P(=O)(O)O
InChI	InChI=1S/C7H11NO7P2/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15)
InChIKey	IIDJRNMFWXDHID-UHFFFAOYSA-N

Chemical Details
Formal Charge	0
Atom Count	28
Chiral Atom Count	0
Bond Count	28
Aromatic Bond Count	6

Drug Info: DrugBank

DrugBank ID	DB00884 ?
Name	Risedronic acid
Groups	approved investigational
Description	Risedronic acid is a third generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label][A959].
Synonyms	Risedronate Risedronic acid Acido risedronico Acide risédroniqe Risedronate sodium Risedronate sodium monohydrate Risedronate sodium hemi-pentahydrate Risedrons?ure Acidum risedronicum
Brand Names	Actonel Dr Actonel Sachet Kit Ntp-risedronate Jamp-risedronate Actonel Aa-risedronate Dr Riva-risedronate Risedronate Teva-risedronate Ratio-risedronate Sandoz Risedronate Teva-risedronate/calcium Pendo-risedronate Apo-risedronate PMS-risedronate Dom-risedronate Q-risedronate Actonel With Calcium PMS-risedronate Plus Calcium Risedronate Sodium Actonel Plus Calcium Auro-risedronate Risedronate Sodium Amorphous Fv2910cl Mylan-risedronate Atelvia PHL-risedronate Actonel with Calcium
Indication	Risedronic acid is indicated for the treatment of osteoperosis in men, treatment of Paget's disease, treatment and prevention of osteoperosis in postmenopausal women, and treatment and prevention of glucocorticoid-induced osteoperosis[FDA Label].
Categories	Agents Causing Muscle Toxicity Bisphosphonates Bone Density Conservation Agents Calcium-Regulating Hormones and Agents Cardiovascular Agents Drugs Affecting Bone Structure and Mineralization Drugs for Treatment of Bone Diseases Membrane Transport Modulators Musculo-Skeletal System Organophosphonates Organophosphorus Compounds Pyridines
ATC-Code	M05BB07 M05BB02 M05BB04 M05BA07
CAS number	105462-24-6

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Hydroxylapatite	-	unknown	antagonist
Farnesyl pyrophosphate synthase	MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCW...	unknown	inhibitor
Prostaglandin G/H synthase 2	MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFY...	unknown	inducer

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682