SER

SERINE

Created:	1999-07-08
Last modified:	2024-09-27

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112 entries where SER is found as a standalone ligand51 entries where SER is covalently linked to polymer or other heterogen groups 228,724 entries where SER is found in a polymer sequence

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Chemical Details
Formal Charge	0
Atom Count	14
Chiral Atom Count	1
Bond Count	13
Aromatic Bond Count	0

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Chemical Component Summary
Name	SERINE
Systematic Name (OpenEye OEToolkits)	(2S)-2-amino-3-hydroxy-propanoic acid
Formula	C₃ H₇ N O₃
Molecular Weight	105.093
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(N)CO
SMILES	CACTVS	3.341	N[CH](CO)C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	C(C(C(=O)O)N)O
Canonical SMILES	CACTVS	3.341	N[C@@H](CO)C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C([C@@H](C(=O)O)N)O
InChI	InChI	1.03	InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
InChIKey	InChI	1.03	MTCFGRXMJLQNBG-REOHCLBHSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00133 ?
Name	Serine
Groups	nutraceutical investigational
Description	A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from glycine or threonine. It is involved in the biosynthesis of purines; pyrimidines; and other amino acids.
Synonyms	beta-Hydroxyalanine Ser Serine L-Serine (S)-Serine Serinum Serina (S)-2-Amino-3-hydroxypropanoic acid alpha-Amino-beta-hydroxypropionic acid
Brand Names	TrophAmine Vamin N 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Aminosyn 7% Kabiven Olimel 3.3% E Clinimix Essepna Aminosyn II with Electrolytes in Dextrose with Calcium Aminosyn 3.5% M Aminosyn II 7% With 50% Dextrose Primene Aminosyn II 8.5% Injection Aminosyn II with Electrolytes Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) Olimel 7.6% E ProcalAmine Aminosyn II 7% M In 10% Dextrose(dual Chamber) FreAmine HBC Smofkabiven Electrolyte Free FreAmine III Aminosyn Aminosyn-PF 10% 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. Aminosyn-PF 7% Olimel 5.7% E 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Perikabiven Aminosyn-PF Nutrineal Pd4 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec Aminosyn 8.5% Aminosyn 10% W Electrolytes Olimel 5.7% Aminosyn II 8.5% With 50% Dextrose 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Plenamine 20% Prosol Aminosyn II In Dextrose Injection Smofkabiven Peripheral Aminosyn 8.5% Injection With Electrolytes Aminosyn HF Aminosyn Sulfite Free 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Renamin (amino Acids) Injection Vamin 18 Electrolyte-free Synthamin Aminosyn II and Dextrose Aminosyn II Primene 10% 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex Periolimel 2.5% E Smofkabiven Extra Nitrogen Aminosyn II 10% With Electrolytes Clinisol Smofkabiven Aminosyn II 5% Inj 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Aminosyn II 7% With 10% Dextrose 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Primene 10%-liq IV Olimel 4.4% Premasol - sulfite-free (Amino Acid) Olimel 7.6% Olimel 4.4% E 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Aminosyn II in Dextrose Aminosyn 5% RenAmin Novamine Travasol 4.25%travasol Amino Acid InJ.W.elecw.5%dex. 8.5% Freamine III Aminosyn II 7% Injection 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose HepatAmine Clinimix E Hepatasol ProSol Smofkabiven Extra Nitrogen Electrolyte Free 4.25%trav. Amino Acid InJ.W.O.elect.5%dext.
Indication	Used as a natural moisturizing agent in some cosmetics and skin care products.
Categories	Amino Acids Amino Acids, Neutral Amino Acids, Peptides, and Proteins Dietary Supplements Proteinogenic Amino Acids Supplements
CAS number	56-45-1

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Cystathionine beta-synthase	MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWIRPDAPS...	unknown
L-serine dehydratase/L-threonine deaminase	MMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRGIGHFCK...	unknown
Serine racemase	MCAQYCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQ...	unknown
Serine palmitoyltransferase 2	MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQ...	unknown
Serine palmitoyltransferase 1	MATATEQWVLVEMVQALYEAPAYHLILEGILILWIIRLLFSKTYKLQERS...	unknown
Serine--tRNA ligase, cytoplasmic	MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRA...	unknown
Alanine--glyoxylate aminotransferase	MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMS...	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
PubChem	5951, 6857581
ChEMBL	CHEMBL11298
ChEBI	CHEBI:17115, CHEBI:33384
CCDC/CSD	ZIXBOA, AYACUZ, NELRAX, RIWKUD01, DLSERN34, YIGLUX, DLSERN12, XENXUL02, TIXGOW, MIFQUN05, MIFQUN04, MIFQUN06, EYOQOY, MIFQUN07, MIFQUN08, MIFQUN03, VOKHEJ, MIFQUN02, JEJVEA, MIFQUN10, MIFQUN, XATVUK, REZPET, AJODUA, MIFQUN09, JEJVAW, REZPAP, BUTBOJ, GUQBUR, AJODOU, KERMID, XENXUL01, XENXUL, TACPAS, PAZCUO01