SER

SERINE

Created:	1999-07-08
Last modified:	2024-09-27

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111 entries where SER is found as a standalone ligand51 entries where SER is covalently linked to polymer or other heterogen groups 224,364 entries where SER is found in a polymer sequence

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Chemical Details
Formal Charge	0
Atom Count	14
Chiral Atom Count	1
Bond Count	13
Aromatic Bond Count	0

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Chemical Component Summary
Name	SERINE
Systematic Name (OpenEye OEToolkits)	(2S)-2-amino-3-hydroxy-propanoic acid
Formula	C₃ H₇ N O₃
Molecular Weight	105.093
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(N)CO
SMILES	CACTVS	3.341	N[CH](CO)C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	C(C(C(=O)O)N)O
Canonical SMILES	CACTVS	3.341	N[C@@H](CO)C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C([C@@H](C(=O)O)N)O
InChI	InChI	1.03	InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
InChIKey	InChI	1.03	MTCFGRXMJLQNBG-REOHCLBHSA-N

Drug Info: DrugBank

DrugBank ID	DB00133 ?
Name	Serine
Groups	investigational nutraceutical
Description	A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from glycine or threonine. It is involved in the biosynthesis of purines; pyrimidines; and other amino acids.
Synonyms	L-Serine (S)-2-Amino-3-hydroxypropanoic acid Serina Serine (S)-Serine Serinum beta-Hydroxyalanine alpha-Amino-beta-hydroxypropionic acid Ser
Brand Names	Olimel 3.3% E 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Aminosyn-PF 10% Aminosyn II 7% Injection Vamin N Primene 10%-liq IV Aminosyn 10% W Electrolytes 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex ProSol Aminosyn Sulfite Free Smofkabiven Peripheral 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Aminosyn II Nutrineal Pd4 Aminosyn-PF 7% Olimel 4.4% Aminosyn II and Dextrose HepatAmine Aminosyn II 8.5% With 50% Dextrose 20% Prosol Olimel 7.6% E 4.25%travasol Amino Acid InJ.W.elecw.5%dex. Smofkabiven Clinimix E Aminosyn II In Dextrose Injection Aminosyn II with Electrolytes 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Perikabiven Vamin 18 Electrolyte-free 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. Aminosyn II 8.5% Injection Aminosyn II with Electrolytes in Dextrose with Calcium 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Aminosyn II in Dextrose Primene Aminosyn HF Synthamin Olimel 5.7% E Travasol Aminosyn 3.5% M Olimel 7.6% RenAmin 8.5% Freamine III Olimel 4.4% E Aminosyn II 7% With 10% Dextrose Aminosyn-PF Essepna Aminosyn ProcalAmine 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose Smofkabiven Extra Nitrogen Electrolyte Free Aminosyn II 7% M In 10% Dextrose(dual Chamber) Hepatasol 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Renamin (amino Acids) Injection 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Aminosyn 7% Periolimel 2.5% E Kabiven FreAmine HBC 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. FreAmine III Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) Primene 10% 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Aminosyn 8.5% Novamine Clinimix Aminosyn 8.5% Injection With Electrolytes Plenamine Aminosyn 5% Aminosyn II 5% Inj Smofkabiven Extra Nitrogen Aminosyn II 7% With 50% Dextrose Olimel 5.7% 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Smofkabiven Electrolyte Free TrophAmine Premasol - sulfite-free (Amino Acid) Aminosyn II 10% With Electrolytes Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec Clinisol 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose
Indication	Used as a natural moisturizing agent in some cosmetics and skin care products.
Categories	Amino Acids Amino Acids, Neutral Amino Acids, Peptides, and Proteins Dietary Supplements Proteinogenic Amino Acids Supplements
CAS number	56-45-1

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Cystathionine beta-synthase	MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWIRPDAPS...	unknown
L-serine dehydratase/L-threonine deaminase	MMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRGIGHFCK...	unknown
Serine racemase	MCAQYCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQ...	unknown
Serine palmitoyltransferase 2	MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQ...	unknown
Serine palmitoyltransferase 1	MATATEQWVLVEMVQALYEAPAYHLILEGILILWIIRLLFSKTYKLQERS...	unknown
Serine--tRNA ligase, cytoplasmic	MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRA...	unknown
Alanine--glyoxylate aminotransferase	MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMS...	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
PubChem	5951, 6857581
ChEMBL	CHEMBL11298
ChEBI	CHEBI:17115, CHEBI:33384
CCDC/CSD	ZIXBOA, AYACUZ, NELRAX, RIWKUD01, DLSERN34, YIGLUX, DLSERN12, XENXUL02, TIXGOW, MIFQUN05, MIFQUN04, MIFQUN06, EYOQOY, MIFQUN07, MIFQUN08, MIFQUN03, VOKHEJ, MIFQUN02, JEJVEA, MIFQUN10, MIFQUN, XATVUK, REZPET, AJODUA, MIFQUN09, JEJVAW, REZPAP, BUTBOJ, GUQBUR, AJODOU, KERMID, XENXUL01, XENXUL, TACPAS, PAZCUO01