SER

SERINE

Created:	1999-07-08
Last modified:	2024-09-27

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113 entries where SER is found as a standalone ligand51 entries where SER is covalently linked to polymer or other heterogen groups 229,943 entries where SER is found in a polymer sequence

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Chemical Details
Formal Charge	0
Atom Count	14
Chiral Atom Count	1
Bond Count	13
Aromatic Bond Count	0

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Chemical Component Summary
Name	SERINE
Systematic Name (OpenEye OEToolkits)	(2S)-2-amino-3-hydroxy-propanoic acid
Formula	C₃ H₇ N O₃
Molecular Weight	105.093
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(N)CO
SMILES	CACTVS	3.341	N[CH](CO)C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	C(C(C(=O)O)N)O
Canonical SMILES	CACTVS	3.341	N[C@@H](CO)C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C([C@@H](C(=O)O)N)O
InChI	InChI	1.03	InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
InChIKey	InChI	1.03	MTCFGRXMJLQNBG-REOHCLBHSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00133 ?
Name	Serine
Groups	nutraceutical investigational
Description	A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from glycine or threonine. It is involved in the biosynthesis of purines; pyrimidines; and other amino acids.
Synonyms	(S)-Serine Serinum Ser alpha-Amino-beta-hydroxypropionic acid L-Serine Serina beta-Hydroxyalanine Serine (S)-2-Amino-3-hydroxypropanoic acid
Brand Names	Vamin 18 Electrolyte-free Premasol - sulfite-free (Amino Acid) 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. Aminosyn 8.5% Perikabiven Olimel 4.4% E 8.5% Freamine III Aminosyn II 7% With 50% Dextrose Primene Olimel 5.7% E Smofkabiven Peripheral 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Aminosyn-PF 7% Aminosyn II In Dextrose Injection Smofkabiven Aminosyn II 8.5% With 50% Dextrose Olimel 4.4% Travasol ProcalAmine Aminosyn II with Electrolytes in Dextrose with Calcium Clinimix 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Primene 10% Aminosyn II Nutrineal Pd4 RenAmin 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Plenamine Vamin N FreAmine HBC Primene 10%-liq IV Olimel 5.7% 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose ProSol Aminosyn II 5% Inj Aminosyn 8.5% Injection With Electrolytes Kabiven Aminosyn-PF 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Renamin (amino Acids) Injection Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec Novamine Aminosyn 10% W Electrolytes 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Aminosyn II 10% With Electrolytes Aminosyn 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex Clinisol Aminosyn-PF 10% Olimel 7.6% 4.25%travasol Amino Acid InJ.W.elecw.5%dex. Aminosyn HF Aminosyn II 7% With 10% Dextrose Aminosyn 7% Aminosyn II 8.5% Injection Smofkabiven Extra Nitrogen Smofkabiven Electrolyte Free 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Olimel 7.6% E 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. Aminosyn 3.5% M Hepatasol Aminosyn II 7% M In 10% Dextrose(dual Chamber) TrophAmine Essepna HepatAmine 20% Prosol Synthamin Aminosyn II and Dextrose Aminosyn II with Electrolytes 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Aminosyn II in Dextrose Aminosyn II 7% Injection Aminosyn Sulfite Free FreAmine III 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose Olimel 3.3% E 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Aminosyn 5% Periolimel 2.5% E Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) Clinimix E Smofkabiven Extra Nitrogen Electrolyte Free
Indication	Used as a natural moisturizing agent in some cosmetics and skin care products.
Categories	Amino Acids Amino Acids, Neutral Amino Acids, Peptides, and Proteins Dietary Supplements Proteinogenic Amino Acids Supplements
CAS number	56-45-1

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Cystathionine beta-synthase	MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWIRPDAPS...	unknown
L-serine dehydratase/L-threonine deaminase	MMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRGIGHFCK...	unknown
Serine racemase	MCAQYCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQ...	unknown
Serine palmitoyltransferase 2	MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQ...	unknown
Serine palmitoyltransferase 1	MATATEQWVLVEMVQALYEAPAYHLILEGILILWIIRLLFSKTYKLQERS...	unknown
Serine--tRNA ligase, cytoplasmic	MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRA...	unknown
Alanine--glyoxylate aminotransferase	MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMS...	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
PubChem	5951, 6857581
ChEMBL	CHEMBL11298
ChEBI	CHEBI:33384, CHEBI:17115
CCDC/CSD	ZIXBOA, AYACUZ, NELRAX, RIWKUD01, DLSERN34, YIGLUX, DLSERN12, XENXUL02, TIXGOW, MIFQUN05, MIFQUN04, MIFQUN06, EYOQOY, MIFQUN07, MIFQUN08, MIFQUN03, VOKHEJ, MIFQUN02, JEJVEA, MIFQUN10, MIFQUN, XATVUK, REZPET, AJODUA, MIFQUN09, JEJVAW, REZPAP, BUTBOJ, GUQBUR, AJODOU, KERMID, XENXUL01, XENXUL, TACPAS, PAZCUO01