TE4

Tetracaine

Created:	2014-02-11
Last modified:	2021-03-01

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6 entries where TE4 is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	43
Chiral Atom Count	0
Bond Count	43
Aromatic Bond Count	6

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Chemical Component Summary
Name	Tetracaine
Synonyms	2-(dimethylamino)ethyl 4-(butylamino)benzoate
Systematic Name (OpenEye OEToolkits)	2-(dimethylamino)ethyl 4-(butylamino)benzoate
Formula	C₁₅ H₂₄ N₂ O₂
Molecular Weight	264.363
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	12.01	O=C(OCCN(C)C)c1ccc(NCCCC)cc1
SMILES	CACTVS	3.385	CCCCNc1ccc(cc1)C(=O)OCCN(C)C
SMILES	OpenEye OEToolkits	1.7.6	CCCCNc1ccc(cc1)C(=O)OCCN(C)C
Canonical SMILES	CACTVS	3.385	CCCCNc1ccc(cc1)C(=O)OCCN(C)C
Canonical SMILES	OpenEye OEToolkits	1.7.6	CCCCNc1ccc(cc1)C(=O)OCCN(C)C
InChI	InChI	1.03	InChI=1S/C15H24N2O2/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3/h6-9,16H,4-5,10-12H2,1-3H3
InChIKey	InChI	1.03	GKCBAIGFKIBETG-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank ID	DB09085 ?
Name	Tetracaine
Groups	approved vet_approved
Description	Tetracaine is an ester local anaesthetic currently available in combination with lidocaine as a cream and patch.
Synonyms	2-(Dimethylamino)ethyl p-(butylamino)benzoate Tetracaine hydrochloride Metraspray Di?thylamino?thanol ester der p-butylaminobenz?s?ure p-Butylaminobenzoyl-2-dimethylaminoethanol Medihaler-Tetracaine Tetracaine p-(butylamino)benzoic acid β-(dimethylamino)ethyl ester 2-(dimethylamino)ethyl 4-(butylamino)benzoate Tetracaína Tetracaine HCl Tétraca?ne Amethocaine HCl Amethocaine Dicaine
Brand Names	Tetracaine2 Comfortox Tetracaine Eclipse Topical Analgesic LL Tetracaine Pontocaine Pws Inj 20mg/amp Denti-Care Denti-Freeze Topical Anesthetic Strawberry Pain Prescriptives Topical Analgesic LL Cetacaine Spray Denti-care Topical Anesthetic Gel Cetacaine Anesthetic Cetacaine Liquid Super T Lidocaine 23% / Tetracaine 7% Lidocaine 7% / Tetracaine 7% Synera Altacaine Tetracaine Hydrochloride Denticare Pro-freeze Denti-Care Denti-Freeze Topical Anesthetic Raspberry Pontocaine Dps 0.5% Minims Tetracaine Hydrochloride Viractin Gel Denti-Care Denti-Freeze Topical Anesthetic Bubblegum Blt 3 Penichillin Numfast Tetracaine Green Spinal Anesthesia Tray T.R.U.E. Test Thin-Layer Rapid Use Patch Test Kovanaze Zap Liquid Pontocaine Dermacaine-R Supracaine Aem 754mg/65gm Burn Solution Cream Denti-Care Denti-Freeze Topical Anesthetic Mint Tetracaine (Base) Pro Plus Spinal Anaesthesia Tray TetraVisc Ametop Gel 4% Blockaid Niphanoid Supracaine Aerosol 11.6mg/gm Panocaine Gel FranklyNumb 3 Pliaglis Denti-care Topical Anesthetic Liquid Spray NeuroMed Topical Analgesic LA Zap Topical Anesthetic Gel Zap Topical Anesthetic Spray Aerosol One Touch Advanced Topical Anesthetic Bubble Gum Denti-Care Denti-Freeze Topical Anesthetic Cherry Plush anesthetics T Benzocaine 20% / Lidocaine 10% / Tetracaine 10% Ndc 72934- 5010-4 Benzocaine 20% / Lidocaine 8% / Tetracaine 4%. One Touch Advanced Topical Anesthetic Cherry Painless Tattoo 3 Blue Gel Anesthetic TetraVisc Forte Zap Topical Anesthetic Spray Ritual Tattoo Reveal Foam Inderma MD Burn Cream Cutiecaine Tetramex BLT Skin Cream tetraVIV Advanced Cold Sore Care One Touch Advanced Topical Anesthetic Strawberry Ice Pontocaine 5 mg/ml Tetracaine HCL Henry Schein Topical Anesthetic Gel Endospray Exactacain Topical Anesthetic Cetacaine Topical Anesthetic NeuroMed LA Sj3 Ritual Tattoo One Touch Advanced Topical Anesthetic Gel Cool Mint Tetragel Punch Topical Analgesic One Touch Topical Anesthetic Gel Lidocaine and Tetracaine Viractin Moisturizing Cream
Indication	Ophthalmic tetracaine is indicated for the for procedures requiring a rapid and short- acting topical ophthalmic anesthetic. The combination lidocaine and tetracaine patch is indicated for local dermal analgesia for superficial dermatological procedures and superficial venous access. The combination lidocaine and tetracaine cream is intended to provide topical local analgesia for superficial dermatological procedures.
Categories	Acids, Carbocyclic Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use Aminobenzoates Anesthetics Anesthetics for Topical Use Anesthetics, General Anesthetics, Local Antipruritics and Local Anesthetics Antipruritics, Incl. Antihistamines, Anesthetics, Etc. Benzene Derivatives Benzoates Central Nervous System Agents Central Nervous System Depressants Dental Agents Dermatologicals Esters of Aminobenzoic Acid Local Anesthesia Local Anesthetics (Ester) Methemoglobinemia Associated Agents Nervous System Ophthalmologicals para-Aminobenzoates Peripheral Nervous System Agents Sensory Organs Sensory System Agents Vasoprotectives
ATC-Code	C05AD02 N01BA03 D04AB06 N01BA53 S01HA03
CAS number	94-24-6

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Ryanodine receptor 1	MGDAEGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEP...	unknown	modulator
Sodium channel protein type 10 subunit alpha	MEFPIGSLETNNFRRFTPESLVEIEKQIAAKQGTKKAREKHREQKDQEEK...	unknown	inhibitor
Ryanodine receptor 2	MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLE...	unknown	modulator
Voltage-gated sodium channel alpha subunit	MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPK...	unknown	blocker

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682