A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under several brand names such as Uniphyl and Theochron, and it is indicated mainly for asthma, bronchospasm, and COPD.
Synonyms
Theophylline anhydrous
1,3-dimethylxanthine
Teofilina
1,3-dimethyl-7H-purine-2,6-dione
Theophylline sodium glycinate
Theophylline
Theophylline, anhydrous
Theophyllin
Brand Names
Theo-SR 300 Srt 300mg
Elixophyllin
Quibron-T
Theolair SR Tab 500mg
Theophylline 0.8mg/ml In 5% Dextrose Inj
PMS-theophylline Elixir
Theo-dur 200 mg
Theophylline
Theophylline (Anhydrous)
Theo-24
Theo-dur 300 mg
Theophylline 1.6mg and 5% Dextrose Inj
Theophylline Anhydrous
Theochron Srt 200mg
Theolair SR Tab 250mg
Theophylline Rougier Elixir
Slo-bid 200
Elixir De Theophylline
Theolair
Theophylline Extended Release
Apo-theo ER
Pulmophylline Elx
Slo-bid 50
Theophylline 0.8mg and 5% Dextrose Inj
Theo ER
Theolair SR Tab 300mg
Slo-bid 300
Senophylline
Aa-theo LA
Ratio-theo-bronc
Idm Tab
Teva-theophylline SR
Theophylline 4mg and 5% Dextrose Inj
Theophylline in Dextrose
Theolair Tab 250mg
Theophylline(Anhydrous)
Theolair Tab 125mg
Theophylline Elixir
Quibron T SR Tab 300mg
Quibron T/SR
Theophylline 80mg/15ml
Theophylline Elx
Theochron Srt 100mg
I D M Expectorant Tab
Uniphyl
Theochron Srt 300mg
Slo-bid 100
Theo-dur 100 mg
Theolair SR Tab 200mg
Theo-dur 450 mg
Tedral Tab
Indication
For the treatment of the symptoms and reversible airflow obstruction associated with chronic asthma and other chronic lung diseases, such as emphysema and chronic bronchitis.
Categories
Agents that reduce seizure threshold
Alkaloids
Anti-Asthmatic Agents
Autonomic Agents
Bronchodilator Agents
Cardiovascular Agents
Cytochrome P-450 CYP1A2 Substrates
Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index
Cytochrome P-450 CYP2C8 Substrates
Cytochrome P-450 CYP2D6 Substrates
Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index
Cytochrome P-450 CYP2E1 Substrates
Cytochrome P-450 CYP2E1 Substrates with a Narrow Therapeutic Index
Cytochrome P-450 CYP3A Substrates
Cytochrome P-450 CYP3A4 Substrates
Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682