A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under several brand names such as Uniphyl and Theochron, and it is indicated mainly for asthma, bronchospasm, and COPD.
Synonyms
1,3-dimethyl-7H-purine-2,6-dione
Teofilina
1,3-dimethylxanthine
Theophylline
Theophylline, anhydrous
Theophylline sodium glycinate
Theophylline anhydrous
Theophyllin
Brand Names
Elixir De Theophylline
Theophylline 1.6mg and 5% Dextrose Inj
Theo-dur 450 mg
Aa-theo LA
Theolair Tab 250mg
Theophylline 0.8mg/ml In 5% Dextrose Inj
Theo-dur 200 mg
Quibron T SR Tab 300mg
Theolair SR Tab 250mg
Theophylline
Theophylline Rougier Elixir
Theophylline Elixir
Theophylline(Anhydrous)
PMS-theophylline Elixir
Slo-bid 100
I D M Expectorant Tab
Ratio-theo-bronc
Theolair Tab 125mg
Theo-SR 300 Srt 300mg
Theochron Srt 300mg
Theolair SR Tab 500mg
Theochron Srt 200mg
Theophylline Elx
Theo-dur 100 mg
Pulmophylline Elx
Slo-bid 300
Quibron T/SR
Theo ER
Idm Tab
Theophylline Extended Release
Teva-theophylline SR
Theophylline 0.8mg and 5% Dextrose Inj
Theophylline 4mg and 5% Dextrose Inj
Uniphyl
Slo-bid 200
Senophylline
Theophylline in Dextrose
Theo-24
Elixophyllin
Theolair SR Tab 300mg
Theophylline Anhydrous
Tedral Tab
Theophylline 80mg/15ml
Theolair SR Tab 200mg
Quibron-T
Apo-theo ER
Theo-dur 300 mg
Theochron Srt 100mg
Theolair
Theophylline (Anhydrous)
Slo-bid 50
Indication
For the treatment of the symptoms and reversible airflow obstruction associated with chronic asthma and other chronic lung diseases, such as emphysema and chronic bronchitis.
Categories
Agents that reduce seizure threshold
Alkaloids
Anti-Asthmatic Agents
Autonomic Agents
Bronchodilator Agents
Cardiovascular Agents
Cytochrome P-450 CYP1A2 Substrates
Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index
Cytochrome P-450 CYP2C8 Substrates
Cytochrome P-450 CYP2D6 Substrates
Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index
Cytochrome P-450 CYP2E1 Substrates
Cytochrome P-450 CYP2E1 Substrates with a Narrow Therapeutic Index
Cytochrome P-450 CYP3A Substrates
Cytochrome P-450 CYP3A4 Substrates
Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682