THM
THYMIDINE
Find entries where: THM
is present as a standalone ligand in 42 entries
as a non-polymer is covalently linked to polymer or other heterogen groups 1 entries
is present in a polymer sequence 14 entries
Chemical Component Summary | |
|---|---|
| Name | THYMIDINE |
| Synonyms | DEOXYTHYMIDINE; 2'-DEOXYTHYMIDINE |
| Identifiers | 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione |
| Formula | C10 H14 N2 O5 |
| Molecular Weight | 242.229 |
| Type | DNA OH 5 PRIME TERMINUS |
| Isomeric SMILES | CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)O |
| InChI | InChI=1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m0/s1 |
| InChIKey | IQFYYKKMVGJFEH-XLPZGREQSA-N |
Chemical Details | |
|---|---|
| Formal Charge | 0 |
| Atom Count | 31 |
| Chiral Atom Count | 3 |
| Bond Count | 32 |
| Aromatic Bond Count | 0 |
Drug Info: DrugBank
| DrugBank ID | DB04485? |
|---|---|
| Name | Thymidine |
| Groups |
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| Description | Thymidine is a pyrimidine deoxynucleoside. Thymidine is the DNA nucleoside T, which pairs with deoxyadenosine (A) in double-stranded DNA. In cell biology it is used to synchronize the cells in S phase. |
| Synonyms |
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| Categories |
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| CAS number | 50-89-5 |
Drug Targets
| Name | Target Sequence | Pharmacological Action | Actions |
|---|---|---|---|
| Thymidylate kinase | MLIAIEGVDGAGKRTLVEKLSGAFRAAGRSVATLAFPRYGQSVAADIAAE... | unknown | substrate |
| Uridine phosphorylase | MSKSDVFHLGLTKNDLQGATLAIVPGDPDRVEKIAALMDKPVKLAShref... | unknown | |
| Thymidine kinase | MAACVPPGEAPRSASGTPTRRQVTIVRIYLDGVYGIGKSTTGRVMASAAS... | unknown | substrate |
| Thymidine kinase 2, mitochondrial | MLLWPLRGWAARALRCFGPGSRGSPASGPGPRRVQRRAWPPDKEQEKEKK... | unknown | substrate |
| Nucleoside-specific channel-forming protein tsx | MKKTLLAAGAVLALSSSFTVNAAENDKPQYLSDWWHQSVNVVGSYHTRFG... | unknown | |
| View More | |||
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
Related Resource References
| Resource Name | Reference |
|---|---|
| Pharos | CHEMBL52609 |
| PubChem | 5789 |
| ChEMBL | CHEMBL52609 |
| ChEBI | CHEBI:17748 |
| CCDC/CSD | THYDIN04, THYDIN06, THYDIN02, THYDIN03, THYDIN05, THYDIN01, THYDIN, THYDIN10, THYDIN09, THYDIN08, THYDIN07 |
| COD | 2104143, 2022066 |
