TKT
(3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-INDOLE-3-CARBOXYLATE
Find entries where: TKT
is present as a standalone ligand in 3 entries
Chemical Component Summary | |
|---|---|
| Name | (3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-INDOLE-3-CARBOXYLATE |
| Synonyms | TROPISETRON |
| Identifiers | [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 1H-indole-3-carboxylate |
| Formula | C17 H20 N2 O2 |
| Molecular Weight | 284.353 |
| Type | NON-POLYMER |
| Isomeric SMILES | CN1[C@H]2CC[C@@H]1CC(C2)OC(=O)c3c[nH]c4c3cccc4 |
| InChI | InChI=1S/C17H20N2O2/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16/h2-5,10-13,18H,6-9H2,1H3/t11-,12+,13+ |
| InChIKey | ZNRGQMMCGHDTEI-ITGUQSILSA-N |
Chemical Details | |
|---|---|
| Formal Charge | 0 |
| Atom Count | 41 |
| Chiral Atom Count | 2 |
| Bond Count | 44 |
| Aromatic Bond Count | 10 |
Drug Info: DrugBank
| DrugBank ID | DB11699? |
|---|---|
| Name | Tropisetron |
| Groups |
|
| Description | Tropisetron is an indole derivative with antiemetic activity. As a selective serotonin receptor antagonist, tropisetron competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiotherapy-induced nausea and vomiting. Tropisetron appears to be well tolerated with the most frequently reported adverse effect being headache. Extrapyramidal side effects are rare upon using tropisetron. |
| Synonyms |
|
| Indication | For the prevention of nausea and vomiting induced by cytotoxic therapy and postoperative. |
| Categories |
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| ATC-Code | A04AA03 |
| CAS number | 89565-68-4 |
Drug Targets
| Name | Target Sequence | Pharmacological Action | Actions |
|---|---|---|---|
| 5-hydroxytryptamine receptor 3A | MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVR... | unknown | antagonist |
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
