TMF

5,10-METHYLENE-6-HYDROFOLIC ACID

Find entries where: TMF

is present as a standalone ligand in 2 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 1 entries

Find related ligands:

Similar Ligands (Stereospecific)

Similar Ligands (Quick Screen)

Toggle Hydrogen Toggle Labels

Chemical Component Summary
Name	5,10-METHYLENE-6-HYDROFOLIC ACID
Identifiers	(2R)-2-[[4-[(6aS,8S,10S)-3-amino-1-oxo-4,6a,7,9-tetrahydroimidazo[3,4-f]pteridin-8-yl]phenyl]carbonylamino]pentanedioic acid
Formula	C₂₀ H₂₁ N₇ O₆
Molecular Weight	455.424
Type	NON-POLYMER
Isomeric SMILES	c1cc(ccc1C(=O)N[C@H](CCC(=O)O)C(=O)O)[N@@]2C[C@H]3C=NC4=C([N@]3C2)C(=O)N=C(N4)N
InChI	InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,7,12-13H,5-6,8-9H2,(H,23,30)(H,28,29)(H,32,33)(H3,21,24,25,31)/t12-,13-/m1/s1
InChIKey	BHJAPJNOACHPNI-CHWSQXEVSA-N

Chemical Details
Formal Charge	0
Atom Count	54
Chiral Atom Count	2
Bond Count	57
Aromatic Bond Count	12

Drug Info: DrugBank

DrugBank ID	DB02301 ?
Name	5,10-Methylene-6-Hydrofolic Acid
Groups	experimental
Synonyms	5,10-Methylene-6-Hydrofolic Acid

Drug Targets

Name	Target Sequence	Pharmacological Action
Thymidylate synthase	MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRC...	unknown
Folylpolyglutamate synthase	MNYTETVAYIHSFPRLAKTGDHRRILTLLHALGNPQQQGRYIHVTGTNGK...	unknown
Thymidylate synthase	MLEQPYLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTK...	unknown

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682