Nitroglycerin, also known as glyceryl trinitrate,[A180169] is an organic nitrate and a vasodilating agent [L38369] that was first discovered in 1847.[A249965] Originally used to dynamite, its antianginal effects were identified in the late 1860s after it produced headaches in factory workers while workers with angina pectoris or heart failure experienced relief from chest pain.[A180166,A180172] Its use as a treatment for angina dates back to 1879 and is still used to treat and prevent angina.[A249970] Nitroglycerin causes vasodilation in both arteries and veins.[A180172] Nitroglycerin is used in a variety of different conditions, including angina pectoris due to coronary artery disease,[L7102,L7141,L38369,L42320] peri-operative hypertension, congestive heart failure,[L7099] and chronic anal fissure.[L42445] It is also used to induce intraoperative hypotension.[L7099]
Synonyms
Glycerol, nitric acid triester
Propane-1,2,3-triyl trinitrate
Trinitrine
Glyceroltrinitrat
1,2,3-propanetriyl nitrate
Trinitroglycerin
Nitroglycerine
Nitroglicerina
Nitroglycerin
Glycerol trinitrate
Glyceryl trinitrate
Trinitroglycerol
Glyceroli trinitratis
NG
Nitroglycerol
1,2,3-propanetrioltrinitrate
Glycerin trinitrate
Nitromed
Brand Names
Transderm-nitro 0.2
Transderm-nitro 0.6
Apo-nitroglycerin
Rho-nitro Pumpspray
Nitronal
Rectiv
Mylan-nitro Patch 0.4
Minitran
Nitro-dur 0.2
Nitroglycerin Inj 5mg/ml
Nitroglycerin ER
Gonitro
Nitroglycerin In 5% Dextrose Inj.-400mcg/ml
Nitroglycerin Transdermal Delivery System
Nitroject
Trinipatch 0.6
Minitran - Patch Trd 72mg/26.6 Sq Cm
Mylan-nitro Sublingual Spray
Nitro-dur 0.8
Nitroglycerin Transdermal System
Nitrolingual
Nitro-dur
Nitroject Inj 1mg/ml
Nitrolingual Spray 0.4mg/eam
Mylan-nitro Patch 0.6
Nitroglycerin In 5% Dextrose Inj.-100mcg/ml
Tridil Injection 5mg/ml
Mylan-nitro Patch 0.2
Nitro-dur 0.6
Nitroglycerin in Dextrose
Nitrol
Nitro-Time
Nitro-dur 0.4
Nitroglycerin SR
Trinipatch 0.4
Nitrolingual Pumpspray
Nitroglycerin In Dextrose
Nitroglycerin In 5% Dextrose Inj.-200mcg/ml
Nitrostat
NitroMist
Nitroglycerin Transdermal Infusion System
Nitrong SR Srt 2.6mg
Basic Dental Emergency Kit
Nitroglycerin Slocaps
Transderm-nitro 0.4
Mylan-nitro Patch 0.8
Trinipatch 0.2
Nitroglycerin Injection USP
Nitro-time
Nitro-bid
Transderm-nitro 0.8
Transderm Nitro
Nitrogard-SR Tab 1mg
Nitro-dur 0.3 - 60mg/15 Sq Cm, 0.3mg/hr
Nitroglycerin
Nitroglycerin Lingual
Deluxe Dental Emergency Kit
Indication
Sublingual nitroglycerin is indicated for the acute relief of an attack or acute prophylaxis of angina pectoris due to coronary artery disease.[L7102,L38369,L42320] Transdermal nitroglycerin is indicated for the prevention of angina pectoris due to coronary artery disease.[L7141] Intravenous nitroglycerin is indicated for the treatment of peri-operative hypertension; for control of congestive heart failure in the setting of acute myocardial infarction; for treatment of angina pectoris in patients who have not responded to sublingual nitroglycerin and beta (¦Â)-blockers; and for induction of intraoperative hypotension.[L7099] Topical nitroglycerin ointment is used to treat moderate to severe pain associated with chronic anal fissure.[L42445]
Categories
Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use
Antianginal Agents
Antihypertensive Agents
Cardiac Therapy
Cardiovascular Agents
Compounds used in a research, industrial, or household setting
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
