Nitroglycerin, also known as glyceryl trinitrate,[A180169] is an organic nitrate and a vasodilating agent [L38369] that was first discovered in 1847.[A249965] Originally used to dynamite, its antianginal effects were identified in the late 1860s after it produced headaches in factory workers while workers with angina pectoris or heart failure experienced relief from chest pain.[A180166,A180172] Its use as a treatment for angina dates back to 1879 and is still used to treat and prevent angina.[A249970] Nitroglycerin causes vasodilation in both arteries and veins.[A180172] Nitroglycerin is used in a variety of different conditions, including angina pectoris due to coronary artery disease,[L7102,L7141,L38369,L42320] peri-operative hypertension, congestive heart failure,[L7099] and chronic anal fissure.[L42445] It is also used to induce intraoperative hypotension.[L7099]
Synonyms
Glyceroltrinitrat
1,2,3-propanetriyl nitrate
Trinitroglycerol
Trinitrine
Nitroglycerol
Nitroglycerine
Glyceryl trinitrate
Propane-1,2,3-triyl trinitrate
Nitromed
Nitroglicerina
Glycerol trinitrate
Glycerol, nitric acid triester
1,2,3-propanetrioltrinitrate
NG
Glyceroli trinitratis
Trinitroglycerin
Glycerin trinitrate
Nitroglycerin
Brand Names
NitroMist
Mylan-nitro Patch 0.6
Transderm-nitro 0.2
Trinipatch 0.4
Nitroglycerin In 5% Dextrose Inj.-100mcg/ml
Trinipatch 0.2
Nitroglycerin Transdermal Delivery System
Transderm-nitro 0.4
Rectiv
Transderm-nitro 0.8
Rho-nitro Pumpspray
Nitroglycerin In 5% Dextrose Inj.-200mcg/ml
Nitroglycerin Injection USP
Nitroglycerin Transdermal Infusion System
Nitroglycerin
Nitroglycerin Transdermal System
Nitroglycerin Slocaps
Nitro-Time
Nitrolingual Spray 0.4mg/eam
Nitroject Inj 1mg/ml
Nitro-bid
Nitrolingual
Nitroject
Nitroglycerin In Dextrose
Nitroglycerin Inj 5mg/ml
Apo-nitroglycerin
Minitran
Deluxe Dental Emergency Kit
Mylan-nitro Patch 0.2
Nitro-dur 0.2
Tridil Injection 5mg/ml
Nitro-dur 0.4
Gonitro
Nitrol
Mylan-nitro Patch 0.8
Nitrong SR Srt 2.6mg
Transderm Nitro
Basic Dental Emergency Kit
Trinipatch 0.6
Nitrolingual Pumpspray
Minitran - Patch Trd 72mg/26.6 Sq Cm
Nitrogard-SR Tab 1mg
Nitroglycerin in Dextrose
Nitro-dur 0.3 - 60mg/15 Sq Cm, 0.3mg/hr
Nitro-time
Transderm-nitro 0.6
Nitroglycerin SR
Nitronal
Nitroglycerin Lingual
Mylan-nitro Patch 0.4
Nitroglycerin ER
Nitroglycerin In 5% Dextrose Inj.-400mcg/ml
Nitro-dur 0.8
Nitrostat
Nitro-dur 0.6
Nitro-dur
Mylan-nitro Sublingual Spray
Indication
Sublingual nitroglycerin is indicated for the acute relief of an attack or acute prophylaxis of angina pectoris due to coronary artery disease.[L7102,L38369,L42320] Transdermal nitroglycerin is indicated for the prevention of angina pectoris due to coronary artery disease.[L7141] Intravenous nitroglycerin is indicated for the treatment of peri-operative hypertension; for control of congestive heart failure in the setting of acute myocardial infarction; for treatment of angina pectoris in patients who have not responded to sublingual nitroglycerin and beta (¦Â)-blockers; and for induction of intraoperative hypotension.[L7099] Topical nitroglycerin ointment is used to treat moderate to severe pain associated with chronic anal fissure.[L42445]
Categories
Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use
Antianginal Agents
Antihypertensive Agents
Cardiac Therapy
Cardiovascular Agents
Compounds used in a research, industrial, or household setting
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
