Trimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of tetrahydrofolic acid (THF) - in doing so, it prevents the synthesis of bacterial DNA and ultimately continued bacterial survival.[L11893] Trimethoprim is often used in combination with [sulfamethoxazole] due to their complementary and synergistic mechanisms but may be used as a monotherapy in the treatment and/or prophylaxis of urinary tract infections.[L11893,L11830] It is structurally and chemically related to [pyrimethamine], another antifolate antimicrobial used in the treatment of plasmodial infections.[T707]
Sulfamethoxazole and Trimethoprim (Double Strength)
Nu-cotrimox Sus 40/8mg/ml
Coptin Oral Suspension
Teva-trimel
Polytrim Ophthalmic Solution
Septra DS
Sulfamethox-TMP DS
Polymyxin B Sulfate and Trimethoprim Sulfate
Bactrim DS
Teva-trimel DS
Protrin Df Tab
Polytrim
Proloprim 200 Tab 200mg
Septra Injection
Bactrim DS Roche Tab
SULFAMETHOXAZOLE and TRIMETHOPRIM
Septra
SulfatrimTM Pediatric Suspension
Bactrim Roche Inj
Trimethoprim
Primsol
Sulfamethoxazole and Trimethoprim
Nu-cotrimox-DS Tab 800/160mg
Sulfamethoxazole and Trimethoprim DS
Protrin Tab
Sulfamethoxazole and Trimethoprim Injection, BP
Bactrim
Sulfamethoxazole and Trimethoprim Double Strength
Sulfatrim
Coptin Tab
Sulfamethoxazole and Trimethoprim for Injection, USP
Roubac Tab 160/800
Septra DS Tablets
Bactrim Roche Tab
sulfamethoxazole-trimethoprim (SMZ)
TRIMPEX trimethoprim hydrochloride
Trisulfa Tab
Nu-cotrimox Tab 400/80mg
Sulfatrim Pediatric
Trimethoprim sulfate and Polymyxin B sulfate
Sulfamethoxazole and Trimethoprim Tablets
Sulfameth/Trimeth-DS
Bactrim Roche Suspension Paediatric
Sulfatrim DS
Sandoz Polytrimethoprim
Septra Pediatric Suspension
SULFAMETHOXAZOLE AND TRIMETHOPRIM double strength
Apo-sulfatrim Oral Suspension
PMS-polytrimethoprim
Polymyxin B Sulfate and Trimethoprim
POLYMYXIN B SULFATE and TRIMETHOPRIM SULFATE
PrimSol
Riva-sep DS
Proloprim Tab 100mg
Trisulfa S Suspension
Trimethoprim Tablets
Indication
As a monotherapy, trimethoprim is indicated for the treatment of acute episodes of uncomplicated urinary tract infections caused by susceptible bacteria, including _E. coli._, _K. pneumoniae_, _Enterobacter spp._, _P. mirabilis_, and coagulase-negative _Staphylococcus_ species.[L11893,L11890] In various formulations in combination with [sulfamethoxazole], trimethoprim is indicated for the following infections caused by bacteria with documented susceptibility: urinary tract infections, acute otitis media in pediatric patients (when clinically indicated), acute exacerbations of chronic bronchitis in adults, enteritis caused by susceptible _Shigella_, prophylaxis and treatment of _Pneumocystis jiroveci_ pneumonia, and travelers' diarrhea caused by enterotoxigenic _E. coli_.[L11830,L11863] Trimethoprim is available as an ophthalmic solution in combination with [polymyxin B] for the treatment of acute bacterial conjunctivitis, blepharitis, and blepharoconjunctivitis caused by susceptible bacteria.[L11887]
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
