Trimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of tetrahydrofolic acid (THF) - in doing so, it prevents the synthesis of bacterial DNA and ultimately continued bacterial survival.[L11893] Trimethoprim is often used in combination with [sulfamethoxazole] due to their complementary and synergistic mechanisms but may be used as a monotherapy in the treatment and/or prophylaxis of urinary tract infections.[L11893,L11830] It is structurally and chemically related to [pyrimethamine], another antifolate antimicrobial used in the treatment of plasmodial infections.[T707]
Sulfamethoxazole and Trimethoprim for Injection, USP
Polytrim
Septra Grape
Apo-sulfatrim Oral Suspension
Septra Pediatric Suspension
sulfamethoxazole-trimethoprim (SMZ)
Septra
Bactrim DS Roche Tab
Sulfamethoxazole and Trimethoprim Tablets
Trisulfa S Suspension
Septra DS Tablets
Coptin Tab
Sulfamethox-TMP DS
Teva-trimel
Riva-sep DS
PrimSol
Proloprim
SULFAMETHOXAZOLE and TRIMETHOPRIM
Coptin Oral Suspension
PMS-polytrimethoprim
SulfatrimTM Pediatric Suspension
Proloprim Tab 100mg
Protrin Df Tab
Trimethoprim Tablets
Bactrim
Sulfameth/Trimeth-DS
Sulfatrim
Nu-cotrimox-DS Tab 800/160mg
Polymyxin B Sulfate and Trimethoprim Sulfate
Bactrim Roche Inj
Polymyxin B Sulfate and Trimethoprim
Nu-cotrimox Tab 400/80mg
Sulfamethoxazole and Trimethoprim
Sulfamethoxazole and Trimethoprim Double Strength
Nu-cotrimox Sus 40/8mg/ml
Proloprim 200 Tab 200mg
Polytrim Ophthalmic Solution
Roubac Tab 160/800
Roubac Tab 80/400
Sulfamethoxazole and Trimethoprim (Double Strength)
Sulfamethoxazole and Trimethoprim Injection, BP
Sulfamethoxazole and Trimethoprim DS
Trimethoprim sulfate and Polymyxin B sulfate
Trimethoprim
Trisulfa DS Tab
Primsol
Indication
As a monotherapy, trimethoprim is indicated for the treatment of acute episodes of uncomplicated urinary tract infections caused by susceptible bacteria, including _E. coli._, _K. pneumoniae_, _Enterobacter spp._, _P. mirabilis_, and coagulase-negative _Staphylococcus_ species.[L11893,L11890] In various formulations in combination with [sulfamethoxazole], trimethoprim is indicated for the following infections caused by bacteria with documented susceptibility: urinary tract infections, acute otitis media in pediatric patients (when clinically indicated), acute exacerbations of chronic bronchitis in adults, enteritis caused by susceptible _Shigella_, prophylaxis and treatment of _Pneumocystis jiroveci_ pneumonia, and travelers' diarrhea caused by enterotoxigenic _E. coli_.[L11830,L11863] Trimethoprim is available as an ophthalmic solution in combination with [polymyxin B] for the treatment of acute bacterial conjunctivitis, blepharitis, and blepharoconjunctivitis caused by susceptible bacteria.[L11887]
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
