Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole has many advantages over the other antifungal drugs including the option of oral administration. The side effect profile of this drug is minimal. It has been demonstrated as an efficacious treatment for vaginal yeast infections in one single dose.[A174325]
Synonyms
Diflucan
Fluconazole
Difluconazole
Fluconazolum
Triflucan
Fluconazol
Brand Names
Canesoral
Co Fluconazole-150
Fluconazole in Sodium Chloride
PMS-fluconazole-150
Mar-fluconazole-150
Jamp-fluconazole
Fluconazole in Dextrose
Fluconazole 150
Monicure
Taro-fluconazole
Act Fluconazole
Novo-fluconazole-150
Fluconazole Omega
Fluconazole Tablets
Pro-fluconazole
Fluconazole Injection Sdz
Jamp Fluconazole 150 mg
Fluconazole
Fluconazole Injection
Fluconazole In Sodium Chloride Injection USP
Mylan-fluconazole
Novo-fluconazole
PMS-fluconazole
Nu-fluconazole-150
Bio-fluconazole
Teva-fluconazole
Dom-fluconazole
Canesoral Combi 1 Day
Extra Strength Clotrimazole Extra Fort -fluconazole Combi
Fluconazole can be administered in the treatment of the following fungal infections[L11043]: 1) Vaginal yeast infections caused by Candida 2) Systemic Candida infections 3) Both esophageal and oropharyngeal candidiasis 4) Cryptococcal meningitis 5) UTI (urinary tract infection) by Candida 6) Peritonitis (inflammation of the peritoneum) caused by Candida **A note on fungal infection prophylaxis** Patients receiving bone marrow transplantation who are treated with cytotoxic chemotherapy and/or radiation therapy may be predisposed to candida infections, and may receive fluconazole as prophylactic therapy.[L11043] **A note on laboratory testing** Obtaining specimens for fungal culture and other important laboratory studies such as serology or pathology is advised before starting fluconazole therapy in order to isolate the organisms to be eliminated through treatment. It is permissible to start therapy before the results are available, however, adjusting the therapy once laboratory results confirm the causative organism may be necessary.[L11043]
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
