TRS
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Find entries where: TRS
is present as a standalone ligand in 2,200 entries
as a non-polymer is covalently linked to polymer or other heterogen groups 24 entries
Chemical Component Summary | |
|---|---|
| Name | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL |
| Synonyms | TRIS BUFFER |
| Identifiers | [1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]azanium |
| Formula | C4 H12 N O3 |
| Molecular Weight | 122.143 |
| Type | NON-POLYMER |
| Isomeric SMILES | C(C(CO)(CO)[NH3+])O |
| InChI | InChI=1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2/p+1 |
| InChIKey | LENZDBCJOHFCAS-UHFFFAOYSA-O |
Chemical Details | |
|---|---|
| Formal Charge | 1 |
| Atom Count | 20 |
| Chiral Atom Count | 0 |
| Bond Count | 19 |
| Aromatic Bond Count | 0 |
Drug Info: DrugBank
| DrugBank ID | DB03754? |
|---|---|
| Name | Tromethamine |
| Groups | approved |
| Description | An organic amine proton acceptor. It is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used as an alkalizer. (From Merck, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p1424) |
| Synonyms |
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| Brand Names |
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| Indication | For the prevention and correction of metabolic acidosis. |
| Categories |
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| ATC-Code |
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| CAS number | 77-86-1 |
Drug Targets
| Name | Target Sequence | Pharmacological Action | Actions |
|---|---|---|---|
| Amyloid beta A4 protein | MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNG... | unknown | inhibitor |
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
Related Resource References
| Resource Name | Reference |
|---|---|
| PubChem | 3777159, 88088752 |
| ChEBI | CHEBI:46097 |
| CCDC/CSD | DUBXII, CUFSII, GEXRUW, LULKIP, WIYXEH, KORSAL01, POPNAJ, BUZGAE, UREWAQ, TRISHC11, GOLWIN, TUDPIR01, RUVNEC, GADYUI, PIPLOS, TERLIO, PIPMUZ, PEHDEN, TUDPIR, PIPMEJ, XUMLUP, GICHUW, VATVAP, HISMAZ, TEQCAW, PIPLUY, VIPXUQ, PIPMOT, PIPMAF, EDALEC, CIKQIY, SAFXAA, CUYBIJ, PIPLIM, COZBAX, TRISHC10, DOPYUE, RUVNEC01, GADXUH, EPAXAX, ITUXED, CUWSIZ |
| COD | 2221989, 2229955, 2233157 |
