TYR

TYROSINE

Created:	1999-07-08
Last modified:	2024-09-27

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79 entries where TYR is found as a standalone ligand23 entries where TYR is covalently linked to polymer or other heterogen groups 221,863 entries where TYR is found in a polymer sequence

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Chemical Details
Formal Charge	0
Atom Count	24
Chiral Atom Count	1
Bond Count	24
Aromatic Bond Count	6

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Chemical Component Summary
Name	TYROSINE
Systematic Name (OpenEye OEToolkits)	(2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid
Formula	C₉ H₁₁ N O₃
Molecular Weight	181.189
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(N)Cc1ccc(O)cc1
SMILES	CACTVS	3.341	N[CH](Cc1ccc(O)cc1)C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	c1cc(ccc1CC(C(=O)O)N)O
Canonical SMILES	CACTVS	3.341	N[C@@H](Cc1ccc(O)cc1)C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	c1cc(ccc1C[C@@H](C(=O)O)N)O
InChI	InChI	1.03	InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1
InChIKey	InChI	1.03	OUYCCCASQSFEME-QMMMGPOBSA-N

Drug Info: DrugBank

DrugBank ID	DB00135 ?
Name	Tyrosine
Groups	investigational approved nutraceutical
Description	Tyrosine is a non-essential amino acid. In animals it is synthesized from [phenylalanine]. It is also the precursor of [epinephrine], thyroid hormones, and melanin.
Synonyms	L-Tyrosin (S)-(-)-Tyrosine Y Tyr (S)-alpha-amino-4-Hydroxybenzenepropanoic acid Tyrosine Tyrosinum (2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid (S)-3-(p-Hydroxyphenyl)alanine (S)-2-Amino-3-(p-hydroxyphenyl)propionic acid Tirosina L-tyrosine (S)-Tyrosine 4-hydroxy-L-phenylalanine (?)-α-amino-p-hydroxyhydrocinnamic acid (S)-α-amino-4-hydroxybenzenepropanoic acid
Brand Names	Olimel 3.3% E 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Quickmix 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Aminosyn-PF 10% 2.5% Travasol Amino Acid Injection Without Electrolytes In 10% Dextrose Quickmix Appbutamone-D Appformin-D Vamin N Primene 10%-liq IV Aminosyn 10% W Electrolytes 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex 4.25% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix ProSol Aminosyn Sulfite Free Smofkabiven Peripheral 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Nutrineal Pd4 Aminosyn-PF 7% Olimel 4.4% 20% Prosol Olimel 7.6% E Travasol Inj Without Electrolytes 8.5% 4.25%travasol Amino Acid InJ.W.elecw.5%dex. Smofkabiven Clinimix E Appformin 4.25% Amino Acid Injection Without Electrolytes In 20% Dextrose Quickmix 2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Quickmix 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Perikabiven Vamin 18 Electrolyte-free Travasol E 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. Travasol Amino Acid Inj 5.5% 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose 4.25% Travasol Amino Acid Without Electrolytes In 5% Dextrose Quickmix 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix Primene Synthamin Travasol Olimel 5.7% E Aminosyn 3.5% M Olimel 7.6% RenAmin Appbutamone Olimel 4.4% E Aminosyn-PF Essepna Aminosyn 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose Smofkabiven Extra Nitrogen Electrolyte Free 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Renamin (amino Acids) Injection 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Aminosyn 7% Periolimel 2.5% E Oil Kabiven 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. 2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Primene 10% 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Aminosyn 8.5% Novamine Clinimix Aminosyn 8.5% Injection With Electrolytes Plenamine Travasol Amino Acid Inj 8.5% Aminosyn 5% Travasol Inj Without Electrolytes 5.5% Smofkabiven Extra Nitrogen Olimel 5.7% 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Quick Mix 2.5% Travasol Aa With Electrolytes With 25% Dextrose Injec Smofkabiven Electrolyte Free TrophAmine Premasol - sulfite-free (Amino Acid) Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec Clinisol 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose
Indication	Tyrosine is claimed to act as an effective antidepressant, however results are mixed. Tyrosine has also been claimed to reduce stress and combat narcolepsy and chronic fatigue, however these claims have been refuted by some studies.
Categories	Amino Acids Amino Acids, Aromatic Amino Acids, Cyclic Amino Acids, Peptides, and Proteins Dietary Supplements Proteinogenic Amino Acids Supplements
CAS number	60-18-4

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Tyrosine 3-monooxygenase	MPTPDATTPQAKGFRRAVSELDAKQAEAIMVRGQGAPGPSLTGSPWPGTA...	unknown	binder
Tyrosine--tRNA ligase, mitochondrial	MAAPILRSFSWGRWSGTLNLSVLLPLGLRKAHSGAQGLLAAQKARGLFKD...	unknown
Tyrosine--tRNA ligase, cytoplasmic	MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHV...	unknown
Tyrosine aminotransferase	MDPYMIQMSSKGNLPSILDVHVNVGGRSSVPGKMKGRKARWSVRPSDMAK...	unknown
Monocarboxylate transporter 8	MALQSQASEEAKGPWQEADQEQQEPVGSPEPESEPEPEPEPEPVPVPPPE...	unknown	inhibitor
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682