UAS

Phenindione

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Chemical Component Summary
Name	Phenindione
Synonyms	2-phenyl-1H-indene-1,3(2H)-dione
Identifiers	2-phenylindene-1,3-dione
Formula	C₁₅ H₁₀ O₂
Molecular Weight	222.239
Type	NON-POLYMER
Isomeric SMILES	c1ccc(cc1)C2C(=O)c3ccccc3C2=O
InChI	InChI=1S/C15H10O2/c16-14-11-8-4-5-9-12(11)15(17)13(14)10-6-2-1-3-7-10/h1-9,13H
InChIKey	NFBAXHOPROOJAW-UHFFFAOYSA-N

Chemical Details
Formal Charge	0
Atom Count	27
Chiral Atom Count	0
Bond Count	29
Aromatic Bond Count	12

Drug Info: DrugBank

DrugBank ID	DB00498 ?
Name	Phenindione
Groups	approved investigational
Description	An indandione that has been used as an anticoagulant. Phenindione has actions similar to warfarin, but it is now rarely employed because of its higher incidence of severe adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p234)
Synonyms	2-Phenyl-1,3-indandione 2-phenyl-1,3(2H)-Indenedione Phenindion Phenindione 2-phenyl-1,3-diketohydrindene Phénindione Fenindione Phenindionum PID Fenindiona
Indication	For the treatment of pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, mural thrombosis, and thrombophili. Also used for anticoagulant prophylaxis.
Categories	Anticoagulants Blood and Blood Forming Organs Hematologic Agents Indans Indenes Narrow Therapeutic Index Drugs Vitamin K Antagonists
ATC-Code	B01AA02
CAS number	83-12-5

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Vitamin K epoxide reductase complex subunit 1	MGSTWGSPGWVRLALCLTGLVLSLYALHVKAARARDRDYRALCDVGTAIS...	unknown	inhibitor

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682