Chemical Component Summary | |
|---|---|
| Name | 5-FLUOROURACIL |
| Identifiers | 5-fluoro-1H-pyrimidine-2,4-dione |
| Formula | C4 H3 F N2 O2 |
| Molecular Weight | 130.077 |
| Type | NON-POLYMER |
| Isomeric SMILES | C1=C(C(=O)NC(=O)N1)F |
| InChI | InChI=1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9) |
| InChIKey | GHASVSINZRGABV-UHFFFAOYSA-N |
Chemical Details | |
|---|---|
| Formal Charge | 0 |
| Atom Count | 12 |
| Chiral Atom Count | 0 |
| Bond Count | 12 |
| Aromatic Bond Count | 0 |
Drug Info: DrugBank
| DrugBank ID | DB00544? |
|---|---|
| Name | Fluorouracil |
| Groups | approved |
| Description | A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid. |
| Synonyms |
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| Brand Names |
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| Indication | For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, esophageal, gastric, rectum, breast, biliary tract, stomach, head and neck, cervical, pancreas, renal cell, and carcinoid. |
| Categories |
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| ATC-Code |
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| CAS number | 51-21-8 |
Drug Targets
| Name | Target Sequence | Pharmacological Action | Actions |
|---|---|---|---|
| DNA | - | unknown | incorporation into and destabilization |
| RNA | - | unknown | incorporation into and destabilization |
| Thymidylate synthase | MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDR... | unknown | other/unknown |
| Dihydropyrimidine dehydrogenase [NADP(+)] | MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCF... | unknown | substrate |
| Uridine phosphorylase 1 | MAATGANAEKAESHNDCPVRLLNPNIAKMKEDILYHFNLTTSRHNFPALF... | unknown | substrate |
| View More | |||
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
Related Resource References
| Resource Name | Reference |
|---|---|
| Pharos | CHEMBL185 |
| PubChem | 3385, 5281053 |
| ChEMBL | CHEMBL185 |
| ChEBI | CHEBI:46345 |
| CCDC/CSD | BIKHIN01, CAWKAP, FURACL14, WEWTAU, HOZPIX, GUXNEV, QACBAA, FEPKES, UDOVIV, CATGOV, IQILEB, BOLLUK, OPOVAS, QABZOL, DUQXOF, ZOYXAP, IQILAX, DUQXUL, BOLMAR, OPOTUK, OXODOW02, IHISIE, SOBNEE, KUTGIS, IQIKUQ, SANBER, PAHHUC, FEPKIW, RIPVIY, RUXVUD01, FURACL01, FURACL15, CADLUR, PAHHOW, RIPVOE, FURACL03, FUREHX, ZAYLOA, SOBNEE01, SANBIV, FURACL02, DUQXIZ, FURACL, FURMCY, FEPKIW01, NAGTAU, EROBEV, KAGZOL, CAGXER, HAHDED |
| COD | 2020808, 2207359, 4506049, 7052012, 2204298, 4134117 |
