VD3

(1S,3Z)-3-[(2E)-2-[(1R,3AR,7AS)-7A-METHYL-1-[(2R)-6-METHYLHEPTAN-2-YL]-2,3,3A,5,6,7-HEXAHYDRO-1H-INDEN-4-YLIDENE]ETHYLI DENE]-4-METHYLIDENE-CYCLOHEXAN-1-OL

Created:	2006-06-15
Last modified:	2020-06-05

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5 entries where VD3 is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	72
Chiral Atom Count	5
Bond Count	74
Aromatic Bond Count	0

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Chemical Component Summary
Name	(1S,3Z)-3-[(2E)-2-[(1R,3AR,7AS)-7A-METHYL-1-[(2R)-6-METHYLHEPTAN-2-YL]-2,3,3A,5,6,7-HEXAHYDRO-1H-INDEN-4-YLIDENE]ETHYLI DENE]-4-METHYLIDENE-CYCLOHEXAN-1-OL
Synonyms	VITAMIN D3
Systematic Name (OpenEye OEToolkits)	(1S)-3-[2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexan-1-ol
Formula	C₂₇ H₄₄ O
Molecular Weight	384.638
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	OC3CC(=C/C=C1\CCCC2(C)C(C(C)CCCC(C)C)CCC12)\C(=C)CC3
SMILES	CACTVS	3.341	CC(C)CCC[CH](C)[CH]1CC[CH]2C(CCC[C]12C)=CC=C3C[CH](O)CCC3=C
SMILES	OpenEye OEToolkits	1.5.0	CC(C)CCCC(C)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C
Canonical SMILES	CACTVS	3.341	CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2C(/CCC[C@]12C)=C\C=C3/C[C@@H](O)CCC3=C
Canonical SMILES	OpenEye OEToolkits	1.5.0	CC(C)CCC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CCCC2=CC=C3C[C@H](CCC3=C)O)C
InChI	InChI	1.03	InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/t21-,24+,25-,26+,27-/m1/s1
InChIKey	InChI	1.03	QYSXJUFSXHHAJI-RWDMXNMGSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00169 ?
Name	Cholecalciferol
Groups	nutraceutical approved
Description	Vitamin D, in general, is a secosteroid generated in the skin when 7-dehydrocholesterol located there interacts with ultraviolet irradiation - like that commonly found in sunlight [L5689]. Both the endogenous form of vitamin D (that results from 7-dehydrocholesterol transformation), vitamin D3 (cholecalciferol), and the plant-derived form, vitamin D2 (ergocalciferol), are considered the main forms of vitamin d and are found in various types of food for daily intake [L5689]. Structurally, ergocalciferol differs from cholecalciferol in that it possesses a double bond between C22 and C23 and has an additional methyl group at C24 [L5689]. Finally, ergocalciferol is pharmacologically less potent than cholecalciferol, which makes vitamin D3 the preferred agent for medical use [L5689]. Appropriate levels of vitamin D must be upheld in the body in order to maintain calcium and phosphorus levels in a healthy physiologic range to sustain a variety of metabolic functions, transcription regulation, and bone metabolism [A223, L5689, L1782, L5771, F4027, F4042, F4048]. However, studies are also ongoing to determine whether or not cholecalciferol may also play certain roles in cancer, autoimmune disorders, cardiovascular disease, and other medical conditions that may be associated with vitamin D deficiency [L5689].
Synonyms	(+)-vitamin D3 Vitamin D3 (5Z,7E)-(3S)-9,10-secocholesta-5,7,10(19)-trien-3-ol Cholecalciferolum Oleovitamin D3 Vitamin D-3 Colecalciferol Calciol Colecalciferolum (3β,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol Activated 7-dehydrocholesterol CC Cholecalciferol
Brand Names	Junior Multi Vitamins - Regular PreQue 10 Ventrixyl CitraNatal Assure Cavan Folate OB Children's Chewable Multi-vitamin Efferlife Multivitamins and Minerals Advanced AM PM NESTABS ABC Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA Vitramyn Cavan Folate DHA Vp-pnv-dha Relnate DHA N.E.U. Complex Multinate DHA Venexa FE WestGel DHA Cal-mag With Zinc & Vitamin D Pediatric Infuvite Multiple Vitamins Vp-CH-pnv VITAMIN D3 1.25 MG 50000 IU Dietary Supplement Neonatal DHA Multivitamins for Children Vitrexate Prenatal Vitamins Plus Virt-Bal DHA Plus Calcium & Magnesium Citrate Plus D With Manganese, Potassium & Zinc Multi-Vitamin With Fluoride Virt-Select PRENATAL/POSTNATAL Cataplex D Tab 400unit Multi Vitamin Plus Iron Cod Liver Oil Oleovitamin A & D Caps 20min Virt-Advance Xyzbac G Trinatal GT Multivitamin with 0.25 mg Fluoride natelle COMPLETE Vitaday Junior Tab Focalgin CA Maintain Multiple Vitamin & Minerals Children Vitamin Drops Multi Vitamin Drops with Fluoride with Iron Multivitamins and Minerals for Men Pregvit Caltrate 600 Plus D - Tablet Kids Stuff With Iron Tablets Garfield Chewable Multivitamins Tab Tricare Prenatal DHA One CyFolex Prenate Chewable O Calcium 500mg Plus D Tab Zatean-CH Vitamin D3 50mcg (2000IU) Osteoshield Genicin Vita-D Folcyteine Prenate Star Only One - Tablet Vitamin D Animi-3 YYUX Vegan Mama Liquid Vitamin D3 Drops 600 IU Inatal Advance TL-Care DHA Foliflex Fosamax Plus D Prenate Elite PM Caps PrePLUS DuetDHA Balanced Multivitamins and Minerals - Complete Virt Vite GT Obstetrix EC YYUX Organic Liquid Vitamin D3 Drops For Kids 4 plus years 600 IU Triple Vitamin Drops with Fluoride Multiple Vitamins & Minerals Tablets Multi Vitamins & Minerals Prenate Mini AxiFol Women's Formula P.N.P. Vitamin Drink Multivitamines Pour Enfants (chewable Tablets) Osteo Formula Vp-heme Ob DHA MultiVitamin, Iron and Fluoride Drops Complete Multivitamins and Minerals for Children One Per Day Vitamin and Mineral Dietary Supplement Poly-Vitamin with Fluoride Isotonix Calcium Plus Formula Cal/mag 1:1 With Zinc and Vitamin D - Tablet DuetDHA Complete Grand Master Formula Tab Decara Vitamin D MultiVitamin with Fluoride Drops Calcium & Vitamin D Escavite Lexazin Pnv-OB-dha Obtrex One Ortho Folic Nata Komplete Calcium Complex High Grade Nestabs ONE OB Complete Petite Calcium and Magnesium 1:1 Plus Tablets Folvite-D Taron-prex Prenatal PNV-Omega Zatean-Pn Plus Multivit with Fluoride Vitamin D3 Oral Solution VEGICAPS Prenatvite Vitamin D 400 Iu Calcium 600 + D Poly-Vite/Iron Oral Solution PR Natal 430 ec Liquid Calcium Mg Phosphorus and Vit.d-3 C. Vit-min Formula Natural Source Spectrum With Beta Carotene Prenate Essential Usana Calmag Plus Tablets - Tab Neonatal Vitamin Cod Liver Oil Cap Essential Vitamins and Minerals Renate DHA Azesco RE Nata Virt-Nate Ventrixyl Fe NEONATAL Complete HemeNatal OB plus DHA PreNexa premier Decara K Vegicaps Active FE Oyster Shell Calcium with Vitamin D VirtPrex Multivitamin Drops with Fluoride Multi-Vit with Fluoride and Iron Multi Vitamin with Fluoride Vitrexyl One Daily Vitamin and Mineral Dietary Supplement Coral Calcium Plus Vitamin D 210mg/100iu Prenate DHA FloraFol Vena-Bal DHA Pure Calcium calcium VitaPhil Aide Hi Potency Multi Tab Tri-Vit With Fluoride And Iron Drops Nutrifer Plus Tablets Multi-vitamins Cream SetonET Novel-D3 Kimchi Vitamin chewable multivitamin Infuvite Pediatric Antiseptic Skin Cream Vitamin D + Calcium Dietary Supplement Folitin-Z Usana Optimizer Actical Plus Calcium-magnesium-vitamin D3-silicon Tablets Multicaps Men's Multi Master Formula TriStart ONE Ply Vi Sol Chewable Tab Tobakient Numark Multivitamins PNV-Select Calcium 500mg With Vitamin D Folgard Calcium Citrate and Vitamin D 200mg/160iu PreferaOB One Infants' Multiple Vitamin Drops TriAdvance Materna Riva-D 10000 Iu Prenatol-M Mega Vitaminerals Osteo-Poretical Prenatal Vitamin No 53 Iron Fum Folic Acid Docusate CA DHA Riva-D 50000 Iu Calcium & Magnesium With Potassium, Zinc, Manganese & Vitamin D Ciferex Innersource Tab Animal Shapes w/Iron Chewtabs Mvc Calcium and Magnesium Citrate and Vitamin D 250mg/125mg/200iu Tricare Prenatal 2-part Daily Prenatal Vitamin System Vitamine D 10 000 D Vi Sol Infants Drops 400unit/0.6ml Liquical CitraNatal B-Calm Port A Mins Super Cal-mag 300/150 With Vitamin D3 Corvite FE Multinate DHA Extra Nexa Plus Usana Megavitamin Tablets - Tab Complete Natal DHA TriStart DHA Pregnancy Multivitamin Folic 5 Calci-yum Plus Magnesium + D3 Vita Balance 2000 Vita-Rx Diabetic Vitamin Cavan Heme OB Pro Pcos Citrus Nrg Plus Liq Viva Kids - Tab WesNate DHA Zintrexyl-C Poly-Vi-Flor Gummies Vita-vim With Beta-carotene - Tab Tozal PNV Prenatal Vitamin Prenatal Nutra-Z Riva-D 5000 Iu Apcal PRENATE Restore Duet DHA 400 50 Plus Multiple Vitamins & Minerals Multi-Vitamin Fluoride and Iron Drops Novel Vita PrimaCare VemaVite-PRx 2 with Fish-Based DHA NESTABS DHA Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA Vita-desic Livita Adults Fosavance Body Rox NataFort Iron Polysaccharides Folic Acid DHA Children's Vitamins Chewable Tri-Vite Pediatric Oral Solution Nutri-Tab OB plus DHA Livita Children Natalvirt 90dha Menatrol Enviroflex - Tab Osteo Tablets Calcium 650mg With Vitamin D Men's 50+ Quflora Pediatric Drops Super Vita-vim With Beta-carotene - Tab Folivane-PRx DHA PreGen DHA Pro Hers Vanilla VP CH Plus Vitranol Fe D-tabs Leonas Calcium Plus Vitamin D3 Multi-Vitamin Drops with Fluoride and Iron Revesta Extra-Virt Plus DHA H.W. Children's Chewable Multi Vit & Mineral Dry Super Vitamin A Plus D - Cap Tri-VI-sol Drops Prenatal Supplement - Tab Venexa Quflora FE Pediatric Drops Menocal Tab Choice OB DHA Vantavo Vitamin D 1000iu Women's Biomultiple Vitamin and Mineral Supplement Multi Vitamin Drops with Fluoride Materna-tab Triveen-PRx RNF Folcaps Omega-3 Women's Support Tablets Swiss One Multivitamin and Mineral Caplet Jamp-vitamin D Dexivite Zatean-Pn NataChew Multi Vitamin Drops with Fluoride and Iron Childrens Chewable Vitamins Onevite A + D Ointment Osteo-life Sweet Sixteen - Tab Teva-alendronate/cholecalciferol Prenatal Plus Vitamins Central-vite 18 Essential Roxifol-D Vitranol Zavitrol Wellness Formula Multivitamins TL-Folate Children's Chewable Multi-vitamin Complete With Minerals Tri-Vit with Fluoride Drops Vitaphil 90 DHA Cifrazol Paramettes Multivits Plus Iron Tab (teens) Prenatal Vitamins and Minerals Tablets WesTab Plus Twin G.F. Powder Amerix Multivitamin Virt Nate Milltrium Senior Vitamin and Mineral Supplement Se-Natal One Quflora Pediatric Prenaissance Super Cal Mag Plus Tricare Prenatal DHA One Rx Multivitamin OB Complete Gold Active OB Multiple Vitamins K.L. Vitamin-mineral WellFola Rocky Mountain Multiple Vit and Min Mega Tab Vitamines A - D Calcium Q.T. Vitamin and Mineral Drink Mix RediChew algeaSAN reg Prenatal Vitamins Plus Low Iron Prena1 Chew Enrich Core Pack - Children Vitamin and Mineral Supplement Multitabs Liquid Calcium and Magnesium With Vit.d Multi Tabs Florafol FE Pediatric 0.25 mg/mL Multivitamin and Fluoride Liquid Drops Corvite Free Tendera-OB Children Choice Multivit Chewable Tab FolaPrime Tricare Prenatal Compleat TriStart FREE VP-HEME One Decara High Potency Vitamin D3 Vegicaps Folvik-D Multi-Nate 30 NESTABS Prenatal Multi-vitamin/Mineral Supplement Multi-actin Natal PNV Florravite PreNatal 19 Multivitamins and Minerals for Young Women YYUX Vegan Baby Liquid Vitamin D3 Drops 400 IU Calcium With Magnesium and Vitamin D Supplement De Vitamines Et Mineraux Keylosa Escavite Lq Virt-Care One Renate Active Calcium Plus Magnesium, Vitamin D and Silicon Avon Nutrivance Soft Calcium Chews With Vitamin D Cod Liver Oil USP OB Complete Prenatal Pnv Ob DHA Multivitamin & Minerals (iron Free) Natavite Super-pote Vitamin Supplement Hvp Chelated Cal/mag With Zinc and Vitamins C and D Dialyvite Supreme D Mid-life Magnacal 2 Nephrocaps-QT Children's Chewable Multiple Vit.plus Iron Poly-Vi-Flor Sandoz Alendronate/cholecalciferol Triveen-Duo DHA Virt-PN DHA Vitamin D-dry 400 I.U. Thrivite Rx Multi - N.T.O.x Formula - Tab Vitrexate FE Gestamine Comprimes Dexatrim Tablets Am Caps Obstetrix DHA Combo Pack Beta Carotene Provitamin A With D Prenatal Plus Iron Multi-Vit-Flor Adult Infuvite Multiple Vitamins PNV Ferrous Fumarate Docusate Folic Acid Davimet with Iron Spectrum Performa Multivitamins and Minerals Tablets Zolate Omnivex Davimet with Fluoride Tri-Vi-Flor Duet DHA VP CH Ultra PreFol-DHA Mebolic Marnatal F Folet DHA Vp-heme Ob algeaSAN pro Prenatal Formula Tab Liquid Opti-minplex +d CitraNatal Harmony 3.0 Poly-Vite Pediatric Oral Solution RE Prenatal Multivitamin with Iron Extra P.N. Vitamin-mineral Drink Mix Virt-PN Davimet Twin Opti Pwr Daily-Vite Niva-Plus Citranatal B-calm Virt-Nate DHA RayaVit Jamp Alendronate / Vitamin D3 Vitafol Multi Vitamin, Iron and Fluoride Folika-V Medi-10 Liqui Cal-D Virt-Pn Senior Multi One Cal-mag Citrate Zinc & Vitamin D Tablets Jenliva Prenatabs FA Vita Day Tab NovaFerrum 125 Multitam For Kids Only Chewable Multivitamins - Tab Palm Springs Multvit and Min Tab Multi Mega Minerals With Vitamin D Ultimate Tab Edge OB VIL-Rx L.I.P. Complex Vidextra Animi-3 with Vitamin D Osteo-force vitaMedMD Rx Plus Multi-Vit with Fluoride Acti-cal/mag 2:1 + Zinc and D Caplet Calcium Supplement Tab ProFola Port A Mins Super Calcium 375 With Vitamin D3 Osteo Formula Tab Euro-D 50000 Iu Strovite One Caplets Vita-Pac Multivitamins and Minerals for Young Men Children's Vitamins W Iron Chewable PNV Tabs 29-1 Vitamins A, C, D and Fluoride Drops Multi-vitamins With Minerals Ag-vitamine D Cavan One Twin G.F. Powder Vanilla Flavor Finazol FolaGent DHA Onyx Multi-Vitamin with Fluoride Ag-vitamine D Tablets Sandoz D 10 000 Chewable Children's Complete Multivitamins With Essential Minerals Children's Chewable Vit and Min Tab Triple-Vitamin Drops with Fluoride Preplus YYUX Organic Liquid Vitamin D3 Drops For Baby 0-3 years 400 IU Iprical Oncovite Nutri-Tab OB Folplex Multivitamins and Minerals With Betacarotene Tablets Pnv-dha PreferaOB ONE Chewable Multivitamins Plus Iron Vita-vim - Tab RE FAC-x Thrivite 19 CompleteNate Chewable Fortamines 10 Capsules Calcium and Magnesium With Vitamin D PNV Tabs 20-1 G.A.S. Complex Multi Vitamin & Minerals Noxifol-D O-Cal Prenatal Vitamin V & M Vitamin and Mineral Supplement Vitamin D3 Dietary Supplement B & J Formula Dietary Supplement Supplements De Vitamines Et Mineraux Osteo Factors MultiVitamin Drops with Fluoride and Iron Infant Multivitamin Drops Paramettes Chewable Multivits With Iron Tab Zyvit PNV-First Escavite D Folene Multivitamin Nutrilite Double X NovaDHA Baby DHA Ziphex Osteo Regime Prenatvite Plus Envirocomplex Zyvana Pregvit Folic 4 Vp-gstn Hormodausse Plus Calc Et D Tab Pro His Mint FolaMed DHA Puralor CitraNatal Harmony Bal-Care DHA Vinate Care Apo-alendronate/vitamin D3 Swical Extra-fort Fortamines-10 Comprimes Prenatal and Post Partum Supplement Decalcitrol Multi-vitamin Dietary Supplement Quflora FE For Kids Only Chewable Multivit. Plus Iron LiquiCal with Magnesium Duet DHA Balanced PramLyte Childrens Chewable Vitamin Tab Animal Shapes High Potency Calcium AzesChew Prefera OB plus DHA Multra With Iron 24 Multivitamins + Minerals NuFera Recal D Paramettes Chewable Multivitamins Plus Iron FolaMax Multivitamines Et Mineraux Junior Regulier Trinatal Ultra Citrate De Calcium Plus Vitamine D Et Zinc Virt-PN Plus Nexa Select Rx Prenatal Vitamin with Plant-Based DHA O-Cal FA multivitamin Medi Tab PR Natal 430 Adult Formula 50+ Oyster Shell Calcium Super Kids Chewable Multivitamin Multimineral (chewable Tablets) Q.T. #4 Vitamin and Mineral Dietary Supplement Children Choice Multivitamin W Iron Chew Tab Children's Multivitamins With Iron healthy mamaBE WELL ROUNDED BE WELL ROUNDED Vitamin D3 Isotonix Multitech Vitamin Mineral Supplemen PreGenna Se-Plete DHA Sun-rype Vitaburst Formula O-care Vitamin and Mineral Supplement Tri-Vitamin with iron and fluoride Prena1 Plus Men's Multi-Vitamin Fluoride Premium Prenatal - Tablets Viva CT Prenatal Xyzbac L.C. Supplement Luxa-D Magnacal PreNexa Calcium Plus Fosteum Infuvite Adult Bal-Care DHA Essential Avon Vitadvance Multi-kids Complete Riva-D OBTREX DHA Combo Pack Kids Stuff Tablets TL-Select Pre-Tabs DHA Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA Euro-D 10000 Iu L-Methyl PNV DHA D- Trol VITAMIN D3 50000 IU Dietary Supplement Gesticare DHA Prenatvite Complete PreTAB Forty Plus Vitamin Supplement Abavite Bear Essentials Vinacal Kid's Choice Children's Chewable Vitamins - Tab Multi Vitamin and Fluoride Pretrate Prenatrix CitraNatal Essence Super Multi D-Cal SoyCal Liquid Calcium With Vitamin D Actical Plus Calcium-magnesium-vitamin D3-silicon Chewable Calcium-magnesium With K & Zn and Vitamin D3 Port A Mins Super Calcium 750 With Vitamin D3 Vitamin D 400 Iu Tablets Vol-Nate Vitamin D3 Oral Solution Vitafol Nano Floriva Plus Formula 3200 Waf 100unit Calcium 600mg + Vit D3 125unit Tab Cavan Alpha Calma-D Select-OB Plus DHA Prenatal Supplement Plus DHA Melittin Joint Soothing Ge CitraNatal Medley MultiVitamin with Fluoride Chewable Prenatal Plus Efferlife Calcium 500mg + Vitamin D3 440 Iu + Vitamin C 125mg Multivitamin with Fluoride PRENATE Enhance Tricare Prenatal DHA One With Folate Children's Chewable Multiple Vitamins - Tab Pregvit Folic 5 Calcium Folic Acid Plus D Chewable Folcaps Care One Vol-Plus Focalgin 90 DHA Foltabs Prenatal Moms Choice Rx Actonel Sachet Kit Calcium Citrate With Vitamin D PreferaOB Garfield Chewable Multivits Plus Iron Tab Zalvit Multitol-M Children's Chewable Multivitamins and Minerals Mor-vites Tab Nexa Select Se-Care Chewable RenaPlex-D Ostachol Florafol Pediatric 0.25 mg/mL Multivitamin and Fluoride Liquid Drops Milk Calcium With Vitamins C, D, and Phosphorous Euro D 10 000 Poly-VI-flor Calcium 250 Mg With Vitamin D Multivitamins and Minerals Tablets Prometa Cal-mag Complete With Zinc, C and D Folet One Mebolex Chewable Multivitamins Neonatal Plus Vitamin Xyzmune Multi-Vitamin Fluoride Drops Premium Prenatal Materna - Tab Multi #2 Ribotin-E Obstetrix ONE Super Charged Energy WesCap-PN DHA T.A. Vit A & D Ointment For Kids Only Chewable Multivitamins Multivitamin & Multimineral Pregnancy Multivitamin Growth Supportpatch, Hautuki Bseltzer Multi Vitamin - Mineral T-PA Cap Ultimate OB DHA UltimateCare ONE Folcal DHA Multra Plex Rulavite DHA Vitafol Ultra Hautuki Se-Natal 19 For-2 Vitamin D3-softgel Capsules Vitamin & Mineral Formula 1 Dietary Supplement Vtb Vitamin and Mineral Supplement Orifer F Vitaphil DHA Floriva Vitrexyl plus Iron Alendronate-cholecalciferol Corvite Nutra Boost Sodium Fluoride and Vitamin D Drops Quflora Gummies Provida OB INATAL Ultra UltimateCare ONE NF Prevital Tab Prenate Pixie PNV Prenatal Vitamin Plus Vitamin A Chela Calmag-300 Plus Zinc D3 Prenatal Plus Multivitamin Plus DHA MiniCaps Calcium With Mg Zn Mn Cu CR Si and Vit. C & D Prenatryl LiquiCal Plus Provida DHA Folika-MG MultiVitamin with Fluoride Omniquin YYUX Organic Liquid Vitamin D3 Drops 1000 IU Taron BC Se-Natal 19 Chewable OB Complete 400 Trinaz vitaMedMD One Rx Multi-phyto Capsules Calcium/magnesium/vitamin D - Capsule Corvita Children's Chewable Multivitamins With Minerals Multi-kid Neomultivite Adeks Tablets Select OB Tricare Prenatal P.R.O. Complex RE Nata OB Zavara OB Complete DHA Aces Tab Folika-D Cavan-EC SOD DHA Adrovance A.R.T.H. Away Formula Multivitamins and Minerals for Women Derma-force Tricare Prenatal Quick Dissolve Complete-RF Prenatal Men's Biomultiple Vitamin and Mineral Supplement WesNatal DHA Complete PR Natal 400 PreferaOB plus DHA Trinatal Rx 1 Calcium Et Magnesium Plus Vitamin D PNV Prenatal Plus Multivitamin C-Nate DHA Cavan Prenatal Calplus Multivitamins and Multiminerals Formula Regular Tablet Opti-cal Chewable +d Caplet Chela Calmag-100 Plus Zinc D3 Dayavite Multivitamines Plus Fer Pour Enfants (chewable Tablets) Virt-Tabs Vol-Tab Rx Calcium With Vitamin D 200 Mg/160 Iu Durachol Maximum Once A Day O-calcium 250mg Plus D Osteo-Vit3 Amladex Vital-D Rx V-Natal Prenaissance Plus Genicin Vita-Q D Caps 400 Units Vinate AZ Children's Chewable Multivitamin Complete With Minerals Davimet-M SetonET-EC Dyzbac Silexin Tri Vi Flor Tab Virt-Pn DHA C.H.V. Formula Multivitamines Et Mineraux Reguliers / Regular Multivitamins and Minerals TL-Select DHA One Daily VITES Tri-Vitamin with Fluoride Imubolic KeyFolic Poly-Vi-Flor with Iron Osteo-plus Multivitamin with 1.0 mg Fluoride Vyqua HemeNatal OB Cholecal DF Foltabs Prenatal Plus DHA Nutri-chem Calcium Magnesium With D and Zinc Spark Cap Formula Osg Extra Once A Day Prenatal, DHA YYUX Organic Liquid Vitamin D3 plus K2 Drops One A Day Bone Builder Prena1 High Potency Multivitamins & Minerals Caplets PreNatal Vitamins Plus Re Ob 90 DHA Liquid Cal/mag Plus D Duet DHA 400 ec Neo-vites & Minerals Tab Prenatal Vi-min Redoxon-cal Euro-D 5000 Iu VITAMINS A, C, D and FLUORIDE Zatean-Pn DHA Sincera - Tablets Vitafol Fe Plus PR Natal 400 ec Natalvirt Ca D-Vite Pediatric Oral Liquid Amerix Vitamin D 3
Indication	Cholecalciferol use is indicated for the treatment of specific medical conditions like refractory rickets (or vitamin D resistant rickets), hypoparathyroidism, and familial hypophosphatemia [F4027, F4042]. Concurrently, as one of the most commonly utilized forms of vitamin D, cholecalciferol is also very frequently used as a supplement in individuals to maintain sufficient vitamin d levels in the body or to treat vitamin D deficiency, as well as various medical conditions that can be associated directly or indirectly with vitamin d insufficiency like osteoporosis and chronic kidney disease, among others [A176041, A176044, F4051].
Categories	Alimentary Tract and Metabolism Bone Density Conservation Agents Calcium-Regulating Hormones and Agents Cholecalciferol, antagonists & inhibitors Cholestanes Cholestenes Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (strength unknown) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (moderate) Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Diet, Food, and Nutrition Drugs Affecting Bone Structure and Mineralization Drugs for Treatment of Bone Diseases Food Fused-Ring Compounds Growth Substances Lipids Membrane Lipids Micronutrients Musculo-Skeletal System Physiological Phenomena Secosteroids Steroids Sterols Vitamin D and Analogues Vitamins Vitamins (Fat Soluble)
ATC-Code	M05BB09 M05BX53 M05BB07 M05BB08 A11CC55 M05BB05 A11CC05 M05BB03 M05BB04
CAS number	67-97-0

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Vitamin D3 receptor	MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRR...	unknown	agonist
Vitamin D 25-hydroxylase	MWKLWRAEEGAAALGGALFLLLFALGVRQLLKQRRPMGFPPGPPGLPFIG...	unknown	substrate
Sterol 26-hydroxylase, mitochondrial	MAALGCARLRWALRGAGRGLCPHGARAKAAIPAALPSDKATGAPGAGPGV...	unknown	substrate
Cytochrome P450 2J2	MLAAMGSLAAALWAVVHPRTLLLGTVAFLLAADFLKRRRPKNYPPGPWRL...	unknown	substrate
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	substrate
Cholesterol side-chain cleavage enzyme, mitochondrial	MLAKGLPPRSVLVKGCQTFLSAPREGLGRLRVPTGEGAGISTRSPRPFNE...	unknown	substrate
Cytochrome P450 1A1	MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIG...	unknown	inhibitor
Cytochrome P450 2C8	MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDI...	unknown	inhibitor
Vitamin D-binding protein	MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSR...	unknown
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682