VIV

(2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL

Created:	2003-11-04
Last modified:	2011-06-04

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9 entries where VIV is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	81
Chiral Atom Count	3
Bond Count	82
Aromatic Bond Count	6

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Chemical Component Summary
Name	(2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL
Systematic Name (OpenEye OEToolkits)	(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]chroman-6-ol
Formula	C₂₉ H₅₀ O₂
Molecular Weight	430.706
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	Oc2c(c(c1OC(CCc1c2C)(C)CCCC(C)CCCC(C)CCCC(C)C)C)C
SMILES	CACTVS	3.341	CC(C)CCC[CH](C)CCC[CH](C)CCC[C]1(C)CCc2c(C)c(O)c(C)c(C)c2O1
SMILES	OpenEye OEToolkits	1.5.0	Cc1c(c2c(c(c1O)C)CCC(O2)(C)CCCC(C)CCCC(C)CCCC(C)C)C
Canonical SMILES	CACTVS	3.341	CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(O)c(C)c(C)c2O1
Canonical SMILES	OpenEye OEToolkits	1.5.0	Cc1c(c2c(c(c1O)C)CC[C@@](O2)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)C
InChI	InChI	1.03	InChI=1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3/t21-,22-,29-/m1/s1
InChIKey	InChI	1.03	GVJHHUAWPYXKBD-IEOSBIPESA-N

Drug Info: DrugBank

DrugBank ID	DB00163 ?
Name	Vitamin E
Groups	vet_approved approved nutraceutical
Description	In 1922, vitamin E was demonstrated to be an essential nutrient[A32448]. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active[A176104]. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage[A176104]. The antioxidant effects are currently being researched for use in the treatment of diseases causing bone loss, cardiovascular diseases, diabetes mellitus and associated comorbidities, eye diseases, inflammatory diseases (including skin conditions), lipid disorders, neurological diseases, and radiation damage[A176369]. Though this research is so far inconclusive, vitamin E remains a popular supplement and is generally considered safe by the FDA[FDA Label].
Synonyms	5,7,8-trimethyltocol (2R,4'R,8'R)-α-tocopherol Vitamin E (+)-α-tocopherol d-α-tocopherol alpha-tocopherol (R,R,R)-α-tocopherol
Brand Names	Vitamin E Ointment 50unit/gm Tma Tab Vitamin E 400unit Cap A.C.E.S. Capsules Evening Primrose Oil Cap Bye Bye Burn Lot Complete One A Day Tab Am Caps Cedevita Sugar-free Vitamin Supplement Multivitamins and Minerals With Betacarotene Tablets Vitafol Plus Nexa Select Liquical Prenatal Tendera-OB OB Complete 400 FolaMed DHA Animal Shapes CitraNatal Essence Vasula Tab Organex E 100 Efamol Cap Vitamin E Plus Cap 200units NESTABS DHA Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA Vitamin E U.S.P. 200 I.U. - Cap Vitamine E 400iu Cap Vitaphil 90 DHA Multi-Nate 30 Sveets Coq10 With E400 Iu Vitamin E Cap 400unit Natural Source Femitab Tab Daily Supplement Packs Vitamin E 100 Iu Natural Source Swiss One Multivitamin and Mineral Caplet 24 Multivitamins + Minerals Selenium '100' Plus C&e M.V.I. Paediatric Childrens Chew Multi Vitamin Tab Folivane-PRx DHA Great Day/am Formula Tab Vitamine E Capsules 25ui Super Gardialine Cap 100iu Extra-Virt Plus DHA Vitamin E 200 I.U. Cap Multi Vitamin and Fluoride Maxum Multi-vite L-Methyl PNV DHA Pre-Tabs DHA Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA Maintain Multiple Vitamin & Minerals Classic Swiss One 10 Multivitamin and Mineral Tab Multivitamin with 1.0 mg Fluoride Bio-efa Borage Gla 90 Cap Original Bioscal Forte Multi-vitamin Supplement Capsules Ultimate Tab Floriva Plus Vitamin E 1000 I.U. (natural Source) Vitamin E Cap 200unit Natural Source Mlc Virt-PN Plus Vitamine E Caps 800unit USP Virt-PN DHA E 200 Cap 200unit Vitamines Et Mineraux Enfants 970 Zatean-Pn Plus CitraNatal Medley Vitamin E Cap USP 1000unit O-Cal FA multivitamin Silexin Vita-vim - Tab Rocky Mountain Multiple Vit and Min Mega Tab Multivitamin with Fluoride Vitamin E 400 Iu and Selenium 100mcg Bio-efa Borage Gla 240 Cap Florravite Selenium 200mcg Plus C & E Tab Cavan Prenatal Formula F.E.S. Vitamins Tab Mega Plex IV - Pck Vitamin E Cap 1000unit USP Natural Source Multi 12 Injection Gamma Oil Swiss One Super Vita-vim With Beta-carotene - Tab Vitamin E With Selenium and Zinc Mega Plex III - Pck Fem - Protect Food Nutrition Inc. Men's Vitamin and Mineral Supplement Longevit-E - Capsule Acti-copherols 200 Cap Multi-Vit-Flor Mycellized Vit E Liq 150unit/ml Vitamine E Cap 200unit Vitamin E Caps USP 200unit Webber Vitamin E Cap 400unit Original Liqui-E 27 Units/ml Vitamin E 30unit Ont Natural Vie-CA-rad Capsules Acti-D Alphacopherol Cap 400unit PNV-Omega Poly-Vi-Flor Gummies Vitamin E 1000iu Vitamin E Cap 50unit Childrens Multiple Vit and Min Chew Tab Multitabs Swical-energy 3e Age Nutria VITAMIN D3 1.25 MG 50000 IU Dietary Supplement Leritone Antistress Tricare Prenatal DHA One Rx Multivitamin RE Nata OB Collag-EN Vitamine E 800 Ui Naturelle -cap Vitamin E Cap 800iunf Natural E-gems-M Re Ob 90 DHA Vitamin E Cap 400unit Liqui Vita Fem Time Tab Udamin Sp natelle COMPLETE Natelle One Beta A With Vitamins C and E Plus Selenium Vitamin E Cream W Vitamins A and D Adeks - Dps Avengers Vitamin and Mineral Supplement Super Charged Energy Dr. Chen's Men's Formula Aces Tab Stress Tab With Iron and Vitamin E Vita Balance 2000 Sincera - Tablets Evening Primrose Oil Cap 500mg W Vit E Maxine Vitamin and Mineral Supplement Cell-wise Vita-vim With Beta-carotene - Tab Vitamin E Capsules 800iu Natural Source Spectrum With Beta Carotene Senior Multi One Vitafol Caplet Advanced AM PM Onccor Prenate Elite Multi II IV Vi Tab Twin G.F. Powder Evening Primrose Oil With Vitamin E Kindervites MVC-Fluoride RE Nata Chewable Multiple Vitamins Plus Extra C Vitamin E 800 I.U. Formula F L W Ferulic Acid CE Skin Serum Multi Plex II - Tab Cavan-EC SOD DHA Vitamin E Cap USP 400unit E 100 Iu Acne C-Patch Multiple Vit Plus Iron Tab Multiple Vitamins Plus Iron Tab Pro E Cap 200unit Multinate DHA For-2 Renate C-Nate DHA Vitamine E Cap USP 800unit Vitamin and Mineral Supp Formula 1 Vitamin E Cap 200iu Nf Natural Source Vitamine E 200 U.I. Tianshi Calcium With Natural Source Vitamin E Softgel Capsules Avon Nutrivance Vitamin E Plus H.W. Children's Chewable Multi Vit & Mineral Multi-kid Liquid Vitamin E Geri-plus Cap Vege Swiss One Multivitamin W Chel Mins Tab Vitamin E Capsules 200unit Multiple Vitamins and Minerals Capsules OB Complete DHA Poly-Vi-Sol RE Prenatal Multivitamin with Iron Diacomp - Cap Vitamin E 200iu Chewable VemaVite-PRx 2 with Fish-Based DHA Vitamin E Capsules USP 400 I.U. Adrien Gagnon Formule A-C-E + Selenium Vitamin E 1000 Iu - Water Soluble TL-Select DHA Olympian Vit E Cap 400unit TL-Select Evening Primrose Oil + Vit E Cap Multi Flow Tablets Vitamin E Cap USP 100iu Vimeral Tab Vitamin E 200iu Thuna's PreNexa premier Hi Potency Multi Tab Vitaplex Vitafol-OB Plus DHA Prenatal Supplement Plus DHA Adeks Tablets Vitamin E Ont 1000unit Mycelized Childrens Multi-vitamin Liq E-400 Cap 400unit Vitamine E 100 I.U. Women's Change Formula TriStart ONE FolaGent DHA Vitamine E25vi Capsule Homosistrox Capsules Inner Health Vitamin Supplement Capsules E-prime Vitamin E Supplement Vitamin E Cap 200unit USP Natural Source Anti Fatigue Eye Drops Cellular Formula VirtPrex Hoa 1 Multipack II Formula Cw Luna Vitamin and Mineral Bar for Women Prenatal Vitamin No 53 Iron Fum Folic Acid Docusate CA DHA CitraNatal Harmony 3.0 Vitamin E 400 I.U. (natural Source) Vitamin E 400 + Selenium Cap Tricare Prenatal DHA One With Folate Se-Plete DHA Doctor's Choice Brand for Men Swiss One Timed Release Tab Vitaphil DHA Formula Hh Vitamin E Capsules U.S.P. 400 I.U. Nitro Vites - Tab Children's Chewable Vit and Min Tab Multi-vitamines Enfants Comprime Emuol V Nexa Select Rx Prenatal Vitamin with Plant-Based DHA Webber Vitamin E Cap 400unit Natural Source Keylosa Prost-10 Vitamin and Mineral Supplement Nutra Boost NovaDHA Baby DHA Vitamine E 400 U.I. Extra 11 VITAFOL Gummies RE FAC-x Vege 1 Daily Tab Multi #2 Vitamin E 200 Iu Capsules Cell-wise Natural Source Beta-carotene,vitamin C,e and Selenium Combo Natural Source Vitamine E Capsules Dr. Waltons Baby Powder E 400iu W Selenium 100mcg Real Vitamin Supplement Cap Revitalize Multi-vitamin and Mineral Complex Swiss One Multi Vit & Chel Min Tab P-plus Usana Megavitamin Tablets - Tab Rulavite DHA Vitamin E 25 Iu Thuna's Vita-E Multivit with Fluoride Synergistic Selenium Card-floe II Tab Supplements De Vitamines Et Mineraux Liqui Infant Vitamins Vitamin E 400 Iu Capsules Poly-VI-flor Vitamin D3 Dietary Supplement E 100 Iu Capsules Vitamin E Pure 800 I.U. Relnate DHA Men's Biomultiple Vitamin and Mineral Supplement WesNate DHA Sopalamine 3b Plus Multivitamins and Minerals for Young Women Enrich Core Pack - Children Vitamin and Mineral Supplement Prenatal Vi-min Multivitamin with 0.25 mg Fluoride Children's Chewable Multivitamin and Multimineral Strovite Forte Caplet Now E-400 TL-Fluorivite Natural Source Vitamin E 1000 Iu Vitafol Fe Plus Cedevita Plus Vitamin Supplement Vitamine E Creme 250unit/ml WesCap-PN DHA Multivitamins W Minerals Extra Strength Huile D'onagre Vitamin E Vitamin E 400 I.U. Cap Multi Vitamin, Iron and Fluoride E 200 Cap Natural 200unit Multi Tabs E Vitamin 1000 I.U. (natural Source) One A Day Advance Adults 50+ 50 Plus Reliv So Sense Daily Vitamin Supplement Co-q10 M.R.B. 60mg Nutrol E 200 Cap Virt-Pn DHA Multivitamins and Minerals for Men Multinate DHA Extra One A Day Multiple Vit W Minerals Super Ao Formula Vitamin E 400 Iu USP Multivitamin and Mineral Vitamin E Cap 100unit USP Natural Source Nutrol E-400 Plus Zinc Et Selenium Cap Aces Caplet Vitafol One Daily Energy Brand Vitamin & Mineral Drink Mix NovaMV Multivitamin Bear Essentials Kimchi Vitamin chewable multivitamin Vl Micel E Liq 100unit/ml Selenion Acti-D Alphacopherol Cap 800unit Sopalamine/3b Plus C Folet One Iron Complex E 400 Iu Vp-pnv-dha Vitamin E Ont Vitamin E Acetate Cap 800t Gnc Natural Source Ultra E 400 - Cap Twin G.F. Powder Vanilla Flavor Cps Capsules Multi-force for Women Tab Pro-gla Caps Multi Plex I - Tab Multi Spectrum - Tablet Premium Prenatal Natural Source Vitamin E 400 Iu Phytomin E Cap 200unit Vitamune Niron Komplete Vitamin E 400iu Vitamine E 100ui Capsule Vital Be-100 Vitalife - Capsule Aces Formula/formule A A S Protect Plus SO 60 Vitamin E PreNexa Vitamin E Cap 400unit USP Nat Source Vitamine E Cap 400unit Manganese 50mg Plus B1 & E Tab Complete One-A-day - Tab Webber Vitamin E Cap 800unit Original Twin Opti Pwr Vitamines Et Mineraux Comprimes Vista Advanced AREDS2 Formula Zatean-Pn DHA Vitamine E Cap 100unit Vitamin E Cap 200iu Vitamine E 100cap Multi-force for Adults Tab Selenium Plus C & E Nexa Plus OB Complete Gold Maltlevol Liq Hyper E Tab Feminex 300 Tab Vitamin E and Coq10 Beta-carotene 10,000 Iu With Vitamins C & E Organex E 400 Coenzyme Q10 + VitaPhil Aide Multi Vitamines - Liq Viprot Virt-Select PRENATAL/POSTNATAL Vit E 400unit W Selenium 50mcg Kanga-V Multivitamins & Minerals Multi-Vitamin Vitamin E Cap 800unit USP Multivitamins and Minerals for Young Men Phytomin E Cap 800unit Extra Once A Day Vitamin E Cap 400iu Rogenic Vitamines Et Mineraux Formula Cw-caplet Vitamine E Cap 100iu Gnc Natural Source Ultra E 1000 - Cap Formula-4 Sx Belly Butter Stretch Marks Cream Stress Tab With Zinc, Copper and Vitamin E Triveen-PRx RNF Q-10 Extra -cap TL-Care DHA PreFol-DHA Mega Vitaminerals Organex E 800 Nutra-clear Maltlevol 12 Liq Vitafol OB Caplet Leritone Magnesium & Vitamine E Stretch Mark Cream Taron-prex Prenatal Multivitamins and Minerals for Women Ch-P Cap NovaFerrum Multivitamin with Iron Pediatric Drops Dandruff Cleanser Vitamin E 200 I.U. (natural Source) Spark Cap Mr. Tumee Multi-vitamin Calcium PNV Vyqua Nata Komplete Vitamine E 200 Cap Poly-Vi-Flor Healing Ointment With Vitamin E E 100 Cap Natural 100unit Totalvit Plus Tricare Prenatal DHA One Vitamin E Ont 30unit/gm Vitamin E Cap 100unit Virt-Nate DHA Omega-3 Rx Complete Cream Natural Source Vitamin E 800 Iu Super Kids Chewable Multivitamin Multimineral (chewable Tablets) One Tablet Daily Mens Formula Vitamin E Cap USP Nat Ratio 200unit Beta-CE Cap PM Caps PreGen DHA Renate DHA MultiVitamin, Iron and Fluoride Drops antistressSAN CitraNatal Assure Thera Q Plus Vitamin E 400 Iu Natural Source Vitamin E Z-force Vitamin and Mineral Supplement Vitamin E Cap 800 Unit Natural Tozal Vitaminol Mangadyn Multi Enfants Tab Vitamin E 400 Iu - Capsule Selenium + E Co-q10 M.R.B. 100mg and Vitamin E Black Currant Seed Oil Cap Vitamin E Cap 1000unit Childrens Chewable Tab Prenatal Mega Antioxidant Virt-Pn Floriva Vitamin E Cap 800unit Vitamin E Cap 200unit C.V. Formula Earthpals Children's Chewables Multi-vitamin & Mineral Tablets MultiVitamin with Fluoride Drops Vision E - 134iu/cap PreQue 10 Vitamine E 800 I.U. Prenaissance Vitamin E Cap 1000iu Vol-Plus Reaphirm Plant Source DHA Women's Biomultiple Vitamin and Mineral Supplement Multi 1000 Prenate Essential Vitamin E Cap USP 200iu TriStart FREE Hypo Vites Tab Vitamin E Capsules 400iu Liquid Multicaps Multiple Vitamins Tab
Indication	Vitamin E supplementation is indicated for treatment of vitamin E deficiency which can occur in cystic fibrosis, cholestasis and severe liver disease, abetalipoproteinemia or simply poor diet[A176104,L3063].
Categories	Antioxidants Basic Ointments and Protectants Benzopyrans Biological Factors Compounds used in a research, industrial, or household setting Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Substrates Diet, Food, and Nutrition Dietary Supplements Food Growth Substances Heterocyclic Compounds, Fused-Ring Micronutrients Physiological Phenomena Protective Agents Pyrans Supplements Vitamin E Vitamin E, analogs & derivatives Vitamins Vitamins (Fat Soluble)
CAS number	59-02-9

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
SEC14-like protein 4	MSSRVGDLSPQQQEALARFRENLQDLLPILPNADDYFLLRWLRARNFDLQ...	unknown
SEC14-like protein 3	MSGRVGDLSPKQAETLAKFRENVQDVLPALPNPDDYFLLRWLRARNFDLQ...	unknown
SEC14-like protein 2	MSGRVGDLSPRQKEALAKFRENVQDVLPALPNPDDYFLLRWLRARSFDLQ...	unknown
Nuclear receptor subfamily 1 group I member 2	MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATG...	unknown
Protein kinase C beta type	MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFC...	unknown
Polyunsaturated fatty acid 5-lipoxygenase	MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGA...	unknown
Protein kinase C alpha type	MADVFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFC...	unknown
Diacylglycerol kinase alpha	MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGY...	unknown
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	MDDKAFTKELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRC...	unknown
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	MDEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRC...	unknown
Glutathione S-transferase P	MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLY...	unknown	inhibitor
Glutathione S-transferase omega-1	MSGESARSLGKGSAPPGPVPEGSIRIYSMRFCPFAERTRLVLKAKGIRHE...	unknown	inhibitor
Glutathione S-transferase Mu 3	MSCESSMVLGYWDIRGLAHAIRLLLEFTDTSYEEKRYTCGEAPDYDRSQW...	unknown	inducer
Glutamate--cysteine ligase catalytic subunit	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDE...	unknown	inducer
NAD(P)H dehydrogenase [quinone] 1	MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPI...	unknown	inducer
Heme oxygenase 1	MERPQPDSMPQDLSEALKEATKEVHTQAENAEFMRNFQKGQVTRDGFKLV...	unknown	inducer
Superoxide dismutase [Cu-Zn]	MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHE...	unknown	inducer
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	substrate,inducer
Glutathione S-transferase A2	MAEKPKLHYSNIRGRMESIRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYL...	unknown	inducer
SEC14-like protein 2	MSGRVGDLSPRQKEALAKFRENVQDVLPALPNPDDYFLLRWLRARSFDLQ...	unknown	binder
SEC14-like protein 3	MSGRVGDLSPKQAETLAKFRENVQDVLPALPNPDDYFLLRWLRARNFDLQ...	unknown	binder
Phospholipid transfer protein	MALFGALFLALLAGAHAEFPGCKIRVTSKALELVKQEGLRFLEQELETIT...	unknown	binder
Alpha-tocopherol transfer protein	MAEARSQPSAGPQLNALPDHSPLLQPGLAALRRRAREAGVPLAPLPLTDS...	unknown	binder
Scavenger receptor class B member 1	MGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKNVRIDPSS...	unknown	substrate
Phospholipid-transporting ATPase ABCA1	MACWPQLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYE...	unknown	substrate
NPC1-like intracellular cholesterol transporter 1	MAEAGLRGWLLWALLLRLAQSEPYTTIHQPGYCAFYDECGKNPELSGSLM...	unknown	substrate
ATP-binding cassette sub-family G member 1	MACLMAAFSVGTAMNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLN...	unknown	substrate
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682