Chemical Component Summary | |
|---|---|
| Name | MENADIONE |
| Synonyms | VITAMIN K3; 2-METHYL-1,4-NAPHTHALENEDIONE |
| Identifiers | 2-methylnaphthalene-1,4-dione |
| Formula | C11 H8 O2 |
| Molecular Weight | 172.18 |
| Type | NON-POLYMER |
| Isomeric SMILES | CC1=CC(=O)c2ccccc2C1=O |
| InChI | InChI=1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3 |
| InChIKey | MJVAVZPDRWSRRC-UHFFFAOYSA-N |
Chemical Details | |
|---|---|
| Formal Charge | 0 |
| Atom Count | 21 |
| Chiral Atom Count | 0 |
| Bond Count | 22 |
| Aromatic Bond Count | 6 |
Drug Info: DrugBank
| DrugBank ID | DB00170? |
|---|---|
| Name | Menadione |
| Groups |
|
| Description | A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo. |
| Synonyms |
|
| Indication | The primary known function of vitamin K is to assist in the normal clotting of blood, but it may also play a role in normal bone calcification. |
| Categories |
|
| ATC-Code | B02BA02 |
| CAS number | 58-27-5 |
Drug Targets
| Name | Target Sequence | Pharmacological Action | Actions |
|---|---|---|---|
| Vitamin K-dependent gamma-carboxylase | MAVSAGSARTSPSSDKVQKDKAELISGPRQDSRIGKLLGFEWTDLSSWRR... | unknown | cofactor |
| Vitamin K epoxide reductase complex subunit 1 | MGSTWGSPGWVRLALCLTGLVLSLYALHVKAARARDRDYRALCDVGTAIS... | unknown | cofactor |
| Vitamin K epoxide reductase complex subunit 1-like protein 1 | MAAPVLLRVSVPRWERVARYAVCAAGILLSIYAYHVEREKERDPEHRALC... | unknown | cofactor |
| Prothrombin | MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEE... | unknown | activator |
| Coagulation factor IX | MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSG... | unknown | activator |
| View More | |||
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
Related Resource References
| Resource Name | Reference |
|---|---|
| Pharos | CHEMBL590 |
| PubChem | 4055 |
| ChEMBL | CHEMBL590 |
| ChEBI | CHEBI:28869 |
| CCDC/CSD | IVEJUO, ORACUH, ORADAO, RUYZAO, IVEJUO04, RUYYUH, IVEJUO01 |
| COD | 7225840, 7050129, 7050130 |
