Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent.[L40928] It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma.[L40928] It is also used for high-conditioning before hematopoietic stem cell transplant.[L47890] It is also used to treat uveal melanoma with unresectable hepatic metastases.[L47895]
Synonyms
p-Bis(beta-chloroethyl)aminophenylalanine
p-Di-(2-chloroethyl)amino-L-phenylalanine
L-Phenylalanine mustard
p-L-Sarcolysin
Phenylalanine nitrogen mustard
3-(p-(Bis(2-chloroethyl)amino)phenyl)-L-alanine
Melphalanum
4-(Bis(2-chloroethyl)amino)-L-phenylalanine
Melfalano
p-N,N-bis(2-chloroethyl)amino-L-phenylalanine
p-N-Bis(2-chloroethyl)amino-L-phenylalanine
L-PAM
Melphalan
L-3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine
Phenylalanine mustard
Melphalan hydrochloride
L-Sarcolysine
3-p-(Di(2-chloroethyl)amino)-phenyl-L-alanine
Brand Names
Melphalan hydrochloride
Alkeran
Taro-melphalan
Melphalan
Melphalan Hydrochloride
Evomela
Melphalan for Injection
Hepzato Kit
Phelinun
Indication
Melphalan is indicated for use as a high-dose conditioning treatment prior to hematopoietic stem cell transplantation in patients with multiple myeloma.[L47890] It is also indicated for the palliative treatment of multiple myeloma and for the palliation of non-resectable epithelial carcinoma of the ovary.[L40928] Melphalan is a component of HEPZATO KIT, a liver-directed therapy indicated for the treatment of adults with uveal melanoma with unresectable hepatic metastases affecting less than 50% of the liver and no extrahepatic disease or extrahepatic disease limited to the bone, lymph nodes, subcutaneous tissues, or lung that is amenable to resection or radiation.[L47895]
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
