Y27
(R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE
Find entries where: Y27
is present as a standalone ligand in 5 entries
Chemical Component Summary | |
|---|---|
| Name | (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE |
| Identifiers | 4-[(1R)-1-aminoethyl]-N-pyridin-4-yl-cyclohexane-1-carboxamide |
| Formula | C14 H21 N3 O |
| Molecular Weight | 247.336 |
| Type | NON-POLYMER |
| Isomeric SMILES | C[C@H](C1CCC(CC1)C(=O)Nc2ccncc2)N |
| InChI | InChI=1S/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11-,12-/m1/s1 |
| InChIKey | IYOZTVGMEWJPKR-IJLUTSLNSA-N |
Chemical Details | |
|---|---|
| Formal Charge | 0 |
| Atom Count | 39 |
| Chiral Atom Count | 1 |
| Bond Count | 40 |
| Aromatic Bond Count | 6 |
Drug Info: DrugBank
| DrugBank ID | DB08756? |
|---|---|
| Name | Y-27632 |
| Groups | experimental |
| Description | Y-27632 is an inhibitor of Rho-associated protein kinase. It inhibits calcium sensitization to affect smooth muscle relaxation. |
| Synonyms |
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| Categories |
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| CAS number | 146986-50-7 |
Drug Targets
| Name | Target Sequence | Pharmacological Action | Actions |
|---|---|---|---|
| cAMP-dependent protein kinase catalytic subunit alpha | MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTL... | unknown | |
| cAMP-dependent protein kinase inhibitor alpha | MTDVETTYADFIASGRTGRRNAIHDILVSSASGNSNELALKLAGLDINKT... | unknown | |
| Rho-associated protein kinase 1 | MSTGDSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNK... | unknown | |
| Rho-associated protein kinase 2 | MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGL... | unknown |
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
