LYS

LYSINE

Created:	1999-07-08
Last modified:	2024-09-27

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187 entries where LYS is found as a standalone ligand67 entries where LYS is covalently linked to polymer or other heterogen groups 227,626 entries where LYS is found in a polymer sequence

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Chemical Details
Formal Charge	1
Atom Count	25
Chiral Atom Count	1
Bond Count	24
Aromatic Bond Count	0

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Chemical Component Summary
Name	LYSINE
Systematic Name (OpenEye OEToolkits)	[(5S)-5-amino-6-hydroxy-6-oxo-hexyl]azanium
Formula	C₆ H₁₅ N₂ O₂
Molecular Weight	147.195
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(N)CCCC[NH3+]
SMILES	CACTVS	3.341	N[CH](CCCC[NH3+])C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	C(CC[NH3+])CC(C(=O)O)N
Canonical SMILES	CACTVS	3.341	N[C@@H](CCCC[NH3+])C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C(CC[NH3+])C[C@@H](C(=O)O)N
InChI	InChI	1.03	InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1
InChIKey	InChI	1.03	KDXKERNSBIXSRK-YFKPBYRVSA-O

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00123 ?
Name	Lysine
Groups	nutraceutical approved
Description	Lysine (abbreviated as Lys or K) is an α-amino acid with the chemical formula HO2CCH(NH2)(CH2)4NH2. This amino acid is an essential amino acid, which means that humans cannot synthesize it. Its codons are AAA and AAG. Lysine is a base, as are arginine and histidine. The ε-amino group acts as a site for hydrogen binding and a general base in catalysis. Common posttranslational modifications include methylation of the ε-amino group, giving methyl-, dimethyl-, and trimethyllysine. The latter occurs in calmodulin. Other posttranslational modifications include acetylation. Collagen contains hydroxylysine which is derived from lysine by lysyl hydroxylase. O-Glycosylation of lysine residues in the endoplasmic reticulum or Golgi apparatus is used to mark certain proteins for secretion from the cell.
Synonyms	L-lys 6-ammonio-L-norleucine L-Lysine Lysine dihydrate Lysine L-2,6-Diaminocaproic acid (S)-α,ε-diaminocaproic acid Lysina L-Lysin Lysinum Lysine hydrochloride Lysine monohydrate LYS (S)-2,6-diaminohexanoic acid (S)-lysine Lysine acetate Lysine acid
Brand Names	Premasol - sulfite-free (Amino Acid) 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. 2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Aminosyn II in Dextrose Aminosyn 5% Nutrineal Pd4 Olimel 5.7% E TrophAmine Aminosyn II In Dextrose Injection Travasol Amino Acid Inj 8.5% Aminosyn HF Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) 20% Prosol Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Effervescent Potassium Chloride Xyzmune Aminosyn II 7% M In 10% Dextrose(dual Chamber) 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Aminosyn II 7% With 10% Dextrose 4.25% Travasol Amino Acid Without Electrolytes In 5% Dextrose Quickmix 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Smofkabiven Extra Nitrogen Aminosyn-PF 7% Aminosyn II 5% Inj Aminosyn II with Electrolytes in Dextrose with Calcium Aminosyn II Aminosyn-PF 10% Quick Mix 2.5% Travasol Aa With Electrolytes With 25% Dextrose Injec Travasol Travasol E Travasol Inj Without Electrolytes 5.5% RenAmin Smofkabiven Electrolyte Free Aminosyn II 7% Injection Clinimix Smofkabiven 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Aminosyn RF Injection Primene 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Travasol Inj Without Electrolytes 8.5% 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. Aminosyn RF FreAmine III Essepna Plenamine 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix Olimel 7.6% Clinimix E 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Quickmix HepatAmine Olimel 3.3% E Aminosyn 3.5% M Renamin (amino Acids) Injection 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Lysakare 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Smofkabiven Peripheral ProcalAmine Aminosyn II 10% With Electrolytes ProSol Vamin N Aminosyn II 8.5% With 50% Dextrose Novamine Aminosyn 8.5% Vamin 18 Electrolyte-free 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Travasol Amino Acid Inj 5.5% 2.5% Travasol Amino Acid Injection Without Electrolytes In 10% Dextrose Quickmix Aminosyn 8.5% Injection With Electrolytes NephrAmine Perikabiven Synthamin Olimel 5.7% Aminosyn 10% W Electrolytes 8.5% Freamine III Aminosyn-PF Nephramine Liq IV 2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Quickmix 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Olimel 4.4% Primene 10%-liq IV 4.25%travasol Amino Acid InJ.W.elecw.5%dex. Aminosyn II 7% With 50% Dextrose Aminosyn Olimel 7.6% E Periolimel 2.5% E 4.25% Amino Acid Injection Without Electrolytes In 20% Dextrose Quickmix Aminosyn Sulfite Free Imubolic 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex 4.25% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix FreAmine HBC Primene 10% Kabiven Aminosyn II 8.5% Injection 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Smofkabiven Extra Nitrogen Electrolyte Free Olimel 4.4% E Aminosyn II and Dextrose Aminosyn II with Electrolytes Clinisol Hepatasol Aminosyn 7%
Indication	Supplemental lysine has putative anti-herpes simplex virus activity. There is preliminary research suggesting that it may have some anti-osteoporotic activity.
Categories	Amino Acids Amino Acids, Basic Amino Acids, Diamino Amino Acids, Essential Amino Acids, Peptides, and Proteins Blood and Blood Forming Organs Blood Substitutes and Perfusion Solutions Detoxifying Agents for Antineoplastic Treatment Dietary Supplements I.V. Solution Additives Lysine Proteinogenic Amino Acids Supplements
ATC-Code	V03AF11 B05XB03
CAS number	56-87-1

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
High affinity cationic amino acid transporter 1	MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGV...	unknown
Cationic amino acid transporter 4	MARGLPTIASLARLCQKLNRLKPLEDSTMETSLRRCLSTLDLTLLGVGGM...	unknown
Cationic amino acid transporter 3	MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGV...	unknown
Cationic amino acid transporter 2	MIPCRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGA...	unknown
Lysine--tRNA ligase	MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQ...	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	substrate,inhibitor
Solute carrier family 22 member 4	MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRC...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682