Download MendeleyXChem group deposition
Krojer, T., Talon, R., Fairhead, M., Szykowska, A., Burgess-Brown, N.A., Brennan, P.E., Arrowsmith, C.H., Edwards, A.M., Bountra, C., von Delft, F.To be published.
5S8F
XChem group deposition -- Crystal Structure of the second bromodomain of pleckstrin homology domain interacting protein (PHIP) in complex with N00572d (space group C2)
- PDB DOI: https://doi.org/10.2210/pdb5S8F/pdb
- Deposition Group: G_1002187 (changed state) ExploreG_1002187
- Classification: SIGNALING PROTEIN
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2020-12-17 Released: 2021-01-13
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.18 ?
- R-Value Free: 0.187
- R-Value Work: 0.163
- R-Value Observed: 0.164
This is version 1.1 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| PH-interacting protein | 128 | Homo sapiens | Mutation(s): 0 Gene Names: PHIP, DCAF14, WDR11 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q8WWQ0 (Homo sapiens) Explore Q8WWQ0 Go to UniProtKB: Q8WWQ0 | |||||
PHAROS: Q8WWQ0 GTEx: ENSG00000146247 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q8WWQ0 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| ZHA (Subject of Investigation/LOI) Query on ZHA | B [auth A] | ~{N}-(5-oxidanylidene-7,8-dihydro-6~{H}-naphthalen-2-yl)ethanamide C12 H13 N O2 WEBCZGJWXXPNHB-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.18 ?
- R-Value Free: 0.187
- R-Value Work: 0.163
- R-Value Observed: 0.164
- Space Group: C 1 2 1
Unit Cell:
| Length ( ? ) | Angle ( ? ) |
|---|---|
| a = 82.94 | ¦Á = 90 |
| b = 27.52 | ¦Â = 100.19 |
| c = 56.73 | ¦Ă = 90 |
| Software Name | Purpose |
|---|---|
| REFMAC | refinement |
| Aimless | data scaling |
| PDB_EXTRACT | data extraction |
| XDS | data reduction |
| REFMAC | phasing |
Entry History
Deposition Data
- Released Date: 2021-01-13 Deposition Author(s): Krojer, T., Talon, R., Fairhead, M., Szykowska, A., Burgess-Brown, N.A., Brennan, P.E., Arrowsmith, C.H., Edwards, A.M., Bountra, C., von Delft, F.
Revision History (Full details and data files)
- Version 1.0: 2021-01-13
Type: Initial release - Version 1.1: 2024-03-06
Changes: Data collection, Database references
