Download MendeleyStructural study of the complex of cblC methylmalonic aciduria and homocysteinuria-related protein MMACHC with cyanocobalamin
Feng, Y., Qin, X.To be published.
7WUZ
Structural study of the complex of cblC methylmalonic aciduria and homocysteinuria-related protein MMACHC with cyanocobalamin
- PDB DOI: https://doi.org/10.2210/pdb7WUZ/pdb
- Classification: OXIDOREDUCTASE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2022-02-09 Released: 2023-02-15
- Funding Organization(s): National Natural Science Foundation of China (NSFC)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.93 ?
- R-Value Free: 0.207
- R-Value Work: 0.165
- R-Value Observed: 0.167
This is version 1.1 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Cyanocobalamin reductase / alkylcobalamin dealkylase | 241 | Homo sapiens | Mutation(s): 0 Gene Names: MMACHC EC: 2.5.1.151 (PDB Primary Data), 1.16.1.6 (PDB Primary Data) |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q9Y4U1 (Homo sapiens) Explore Q9Y4U1 Go to UniProtKB: Q9Y4U1 | |||||
PHAROS: Q9Y4U1 GTEx: ENSG00000132763 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q9Y4U1 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 3 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| CNC (Subject of Investigation/LOI) Query on CNC | B [auth A] | CYANOCOBALAMIN C63 H89 Co N14 O14 P SYZBZQWSWIJYAR-UVKKECPRSA-M |  | ||
| TLA (Subject of Investigation/LOI) Query on TLA | C [auth A] | L(+)-TARTARIC ACID C4 H6 O6 FEWJPZIEWOKRBE-JCYAYHJZSA-N |  | ||
| SO4 (Subject of Investigation/LOI) Query on SO4 | D [auth A] | SULFATE ION O4 S QAOWNCQODCNURD-UHFFFAOYSA-L |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.93 ?
- R-Value Free: 0.207
- R-Value Work: 0.165
- R-Value Observed: 0.167
- Space Group: C 1 2 1
Unit Cell:
| Length ( ? ) | Angle ( ? ) |
|---|---|
| a = 72.968 | ¦Á = 90 |
| b = 96.327 | ¦Â = 111.06 |
| c = 47.257 | ¦Ă = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| Aimless | data scaling |
| PDB_EXTRACT | data extraction |
| HKL-2000 | data reduction |
| PHASER | phasing |
Entry History & Funding Information
Deposition Data
| Funding Organization | Location | Grant Number |
|---|---|---|
| National Natural Science Foundation of China (NSFC) | China | 31100529 |
Revision History (Full details and data files)
- Version 1.0: 2023-02-15
Type: Initial release - Version 1.1: 2024-05-29
Changes: Data collection
