Download MendeleySnapshots of acyl carrier protein shuttling in human fatty acid synthase.
Schultz, K., Costa-Pinheiro, P., Gardner, L., Pinheiro, L.V., Ramirez-Solis, J., Gardner, S.M., Wellen, K.E., Marmorstein, R.(2025) Nature
8VLO
Composite structure of human FASN with NADPH in State 2
- PDB DOI: https://doi.org/10.2210/pdb8VLO/pdb
- EM Map EMD-43340: EMDB EMDataResource
- Classification: BIOSYNTHETIC PROTEIN
- Organism(s): Homo sapiens
- Expression System: Spodoptera frugiperda
- Mutation(s): No
- Deposited: 2024-01-11 Released: 2025-02-26
- Funding Organization(s): National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)
Experimental Data Snapshot
- Method: ELECTRON MICROSCOPY
- Resolution: 3.30 Å
- Aggregation State: PARTICLE
- Reconstruction Method: SINGLE PARTICLE
Starting Models: in silico, experimental
View more details
wwPDB Validation 3D Report Full Report
This is version 1.0 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Fatty acid synthase | 2,553 | Homo sapiens | Mutation(s): 0 Gene Names: FASN, FAS EC: 2.3.1.85 (PDB Primary Data), 2.3.1.38 (PDB Primary Data), 2.3.1.39 (PDB Primary Data), 2.3.1.41 (PDB Primary Data), 1.1.1.100 (PDB Primary Data), 4.2.1.59 (PDB Primary Data), 1.3.1.39 (PDB Primary Data), 3.1.2.14 (PDB Primary Data) |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P49327 (Homo sapiens) Explore P49327 Go to UniProtKB: P49327 | |||||
PHAROS: P49327 GTEx: ENSG00000169710 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P49327 | ||||
Sequence AnnotationsExpand | |||||
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Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| NDP (Subject of Investigation/LOI) Query on NDP | C [auth A], D [auth A], E [auth B], F [auth B] | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE C21 H30 N7 O17 P3 ACFIXJIJDZMPPO-NNYOXOHSSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: ELECTRON MICROSCOPY
- Resolution: 3.30 Å
- Aggregation State: PARTICLE
- Reconstruction Method: SINGLE PARTICLE
| Task | Software Package | Version |
|---|---|---|
| MODEL REFINEMENT | PHENIX | 1.20.1_4487: |
| RECONSTRUCTION | cryoSPARC | 4 |
Entry History & Funding Information
Deposition Data
- Released Date: 2025-02-26 Deposition Author(s): Schultz, K., Marmorstein, R.
| Funding Organization | Location | Grant Number |
|---|---|---|
| National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | United States | GM118090 |
Revision History (Full details and data files)
- Version 1.0: 2025-02-26
Type: Initial release
