Download MendeleyStructural Mechanisms Underlying the Modulation of CXCR4 by Diverse Antagonists.
Sang, X.H., Jiao, H.Z., Huang, Z.W., Hu, H.L.To be published.
8ZPL
Cryo-EM strucutre of CXCR4 complexed with antagonist HF51116
- PDB DOI: https://doi.org/10.2210/pdb8ZPL/pdb
- EM Map EMD-60348: EMDB EMDataResource
- Classification: SIGNALING PROTEIN
- Organism(s): Lama glama, Escherichia coli, Homo sapiens
- Expression System: Spodoptera frugiperda
- Mutation(s): No
- Deposited: 2024-05-30 Released: 2025-02-26
- Funding Organization(s): Other government
Experimental Data Snapshot
- Method: ELECTRON MICROSCOPY
- Resolution: 3.01 Å
- Aggregation State: PARTICLE
- Reconstruction Method: SINGLE PARTICLE
wwPDB Validation 3D Report Full Report
This is version 1.0 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Nb6 nanobody | A [auth N] | 169 | Lama glama | Mutation(s): 0 |  |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Soluble cytochrome b562,C-X-C chemokine receptor type 4 | B [auth R] | 486 | Escherichia coli, Homo sapiens | Mutation(s): 0 Gene Names: cybC, CXCR4 |  |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P61073 (Homo sapiens) Explore P61073 Go to UniProtKB: P61073 | |||||
PHAROS: P61073 GTEx: ENSG00000121966 | |||||
Find proteins for P0ABE7 (Escherichia coli) Explore P0ABE7 Go to UniProtKB: P0ABE7 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Groups | P0ABE7P61073 | ||||
Sequence AnnotationsExpand | |||||
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Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| A1D8K (Subject of Investigation/LOI) Query on A1D8K | E [auth R] | (2S)-N-[[4-[[3-(cyclohexylamino)propylamino]methyl]phenyl]methyl]-5-(diaminomethylideneamino)-2-(pyridin-2-ylmethylamino)pentanamide C29 H46 N8 O AMGQQWNQWHMPHG-MHZLTWQESA-N |  | ||
| CLR Query on CLR | C [auth R], D [auth R] | CHOLESTEROL C27 H46 O HVYWMOMLDIMFJA-DPAQBDIFSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: ELECTRON MICROSCOPY
- Resolution: 3.01 Å
- Aggregation State: PARTICLE
- Reconstruction Method: SINGLE PARTICLE
Entry History & Funding Information
Deposition Data
- Released Date: 2025-02-26 Deposition Author(s): Jiao, H.Z., Hu, H.L.
| Funding Organization | Location | Grant Number |
|---|---|---|
| Other government | China | 32100963 |
Revision History (Full details and data files)
- Version 1.0: 2025-02-26
Type: Initial release
