9C07

Structure of K2P13.1 (THIK1) S136P in detergent

PDB DOI: https://doi.org/10.2210/pdb9C07/pdb
EM Map EMD-45075: EMDB EMDataResource

Classification: TRANSPORT PROTEIN
Organism(s): Homo sapiens
Expression System: Homo sapiens
Mutation(s): Yes

Deposited: 2024-05-24 Released: 2025-02-26
Deposition Author(s): Roy-Chowdhury, S., Adberemane-Ali, F., Minor, D.L.
Funding Organization(s): National Institutes of Health/National Institute of Mental Health (NIH/NIMH)

Experimental Data Snapshot

Method: ELECTRON MICROSCOPY
Resolution: 2.73 Å
Aggregation State: PARTICLE
Reconstruction Method: SINGLE PARTICLE

wwPDB Validation 3D Report Full Report

This is version 1.0 of the entry. See complete history.

Literature

The structure of human K2P13.1 (THIK1) shows novel pore restriction and endogenous lipid cofactor

Roy-Chowdhury, S., Adberemane-Ali, F., Minor, D.L.

To be published.

Macromolecule Content

Total Structure Weight: 83.08 kDa
Atom Count: 4,512
Modelled Residue Count: 524
Deposited Residue Count: 700
Unique protein chains: 1

Macromolecules

Find similar proteins by:

(by identity cutoff) | 3D Structure

Entity ID: 1
Molecule	Chains	Sequence Length	Organism	Details	Image
Potassium channel subfamily K member 13	A [auth U], B [auth A]	350	Homo sapiens	Mutation(s): 3 Gene Names: KCNK13
UniProt & NIH Common Fund Data Resources
Find proteins for Q9HB14 (Homo sapiens) Explore Q9HB14 Go to UniProtKB: Q9HB14
GTEx: ENSG00000152315
Entity Groups
Sequence Clusters	30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt Group	Q9HB14
Sequence Annotations Expand
Reference Sequence

Small Molecules

Ligands 6 Unique
ID	Chains	Name / Formula / InChI Key	2D Diagram	3D Interactions
EIC (Subject of Investigation/LOI) Query on EIC Download Ideal Coordinates CCD File SDF format, chain GA [auth A] SDF format, chain P [auth U] MOL2 format, chain GA [auth A] MOL2 format, chain P [auth U] mmCIF format, chain GA [auth A] mmCIF format, chain P [auth U]	GA [auth A], P [auth U]	LINOLEIC ACID C₁₈ H₃₂ O₂ OYHQOLUKZRVURQ-HZJYTTRNSA-N		Interactions Focus chain GA [auth A] Focus chain P [auth U] Interactions & Density Focus chain GA [auth A] Focus chain P [auth U]
R16 Query on R16 Download Ideal Coordinates CCD File SDF format, chain HA [auth A] SDF format, chain V [auth A] MOL2 format, chain HA [auth A] MOL2 format, chain V [auth A] mmCIF format, chain HA [auth A] mmCIF format, chain V [auth A]	HA [auth A], V [auth A]	HEXADECANE C₁₆ H₃₄ DCAYPVUWAIABOU-UHFFFAOYSA-N		Interactions Focus chain HA [auth A] Focus chain V [auth A] Interactions & Density Focus chain HA [auth A] Focus chain V [auth A]
D12 Query on D12 Download Ideal Coordinates CCD File SDF format, chain C [auth U] SDF format, chain D [auth U] SDF format, chain G [auth U] SDF format, chain Q [auth U] SDF format, chain W [auth A] SDF format, chain Z [auth A] MOL2 format, chain C [auth U] MOL2 format, chain D [auth U] MOL2 format, chain G [auth U] MOL2 format, chain Q [auth U] MOL2 format, chain W [auth A] MOL2 format, chain Z [auth A] mmCIF format, chain C [auth U] mmCIF format, chain D [auth U] mmCIF format, chain G [auth U] mmCIF format, chain Q [auth U] mmCIF format, chain W [auth A] mmCIF format, chain Z [auth A]	C [auth U] D [auth U] G [auth U] Q [auth U] W [auth A] C [auth U], D [auth U], G [auth U], Q [auth U], W [auth A], Z [auth A]	DODECANE C₁₂ H₂₆ SNRUBQQJIBEYMU-UHFFFAOYSA-N		Interactions Focus chain C [auth U] Focus chain D [auth U] Focus chain G [auth U] Focus chain Q [auth U] Focus chain W [auth A] Focus chain Z [auth A] Interactions & Density Focus chain C [auth U] Focus chain D [auth U] Focus chain G [auth U] Focus chain Q [auth U] Focus chain W [auth A] Focus chain Z [auth A]
OCT Query on OCT Download Ideal Coordinates CCD File SDF format, chain BA [auth A] SDF format, chain E [auth U] SDF format, chain F [auth U] SDF format, chain I [auth U] SDF format, chain R [auth U] SDF format, chain T [auth A] SDF format, chain X [auth A] SDF format, chain Y [auth A] MOL2 format, chain BA [auth A] MOL2 format, chain E [auth U] MOL2 format, chain F [auth U] MOL2 format, chain I [auth U] MOL2 format, chain R [auth U] MOL2 format, chain T [auth A] MOL2 format, chain X [auth A] MOL2 format, chain Y [auth A] mmCIF format, chain BA [auth A] mmCIF format, chain E [auth U] mmCIF format, chain F [auth U] mmCIF format, chain I [auth U] mmCIF format, chain R [auth U] mmCIF format, chain T [auth A] mmCIF format, chain X [auth A] mmCIF format, chain Y [auth A]	BA [auth A] E [auth U] F [auth U] I [auth U] R [auth U] BA [auth A], E [auth U], F [auth U], I [auth U], R [auth U], T [auth A], X [auth A], Y [auth A]	N-OCTANE C₈ H₁₈ TVMXDCGIABBOFY-UHFFFAOYSA-N		Interactions Focus chain BA [auth A] Focus chain E [auth U] Focus chain F [auth U] Focus chain I [auth U] Focus chain R [auth U] Focus chain T [auth A] Focus chain X [auth A] Focus chain Y [auth A] Interactions & Density Focus chain BA [auth A] Focus chain E [auth U] Focus chain F [auth U] Focus chain I [auth U] Focus chain R [auth U] Focus chain T [auth A] Focus chain X [auth A] Focus chain Y [auth A]
HEX Query on HEX Download Ideal Coordinates CCD File SDF format, chain AA [auth A] SDF format, chain CA [auth A] SDF format, chain DA [auth A] SDF format, chain EA [auth A] SDF format, chain FA [auth A] SDF format, chain H [auth U] SDF format, chain J [auth U] SDF format, chain K [auth U] SDF format, chain L [auth U] SDF format, chain M [auth U] SDF format, chain N [auth U] SDF format, chain O [auth U] SDF format, chain S [auth U] SDF format, chain U [auth A] MOL2 format, chain AA [auth A] MOL2 format, chain CA [auth A] MOL2 format, chain DA [auth A] MOL2 format, chain EA [auth A] MOL2 format, chain FA [auth A] MOL2 format, chain H [auth U] MOL2 format, chain J [auth U] MOL2 format, chain K [auth U] MOL2 format, chain L [auth U] MOL2 format, chain M [auth U] MOL2 format, chain N [auth U] MOL2 format, chain O [auth U] MOL2 format, chain S [auth U] MOL2 format, chain U [auth A] mmCIF format, chain AA [auth A] mmCIF format, chain CA [auth A] mmCIF format, chain DA [auth A] mmCIF format, chain EA [auth A] mmCIF format, chain FA [auth A] mmCIF format, chain H [auth U] mmCIF format, chain J [auth U] mmCIF format, chain K [auth U] mmCIF format, chain L [auth U] mmCIF format, chain M [auth U] mmCIF format, chain N [auth U] mmCIF format, chain O [auth U] mmCIF format, chain S [auth U] mmCIF format, chain U [auth A]	AA [auth A] CA [auth A] DA [auth A] EA [auth A] FA [auth A] AA [auth A], CA [auth A], DA [auth A], EA [auth A], FA [auth A], H [auth U], J [auth U], K [auth U], L [auth U], M [auth U], N [auth U], O [auth U], S [auth U], U [auth A]	HEXANE C₆ H₁₄ VLKZOEOYAKHREP-UHFFFAOYSA-N		Interactions Focus chain AA [auth A] Focus chain CA [auth A] Focus chain DA [auth A] Focus chain EA [auth A] Focus chain FA [auth A] Focus chain H [auth U] Focus chain J [auth U] Focus chain K [auth U] Focus chain L [auth U] Focus chain M [auth U] Focus chain N [auth U] Focus chain O [auth U] Focus chain S [auth U] Focus chain U [auth A] Interactions & Density Focus chain AA [auth A] Focus chain CA [auth A] Focus chain DA [auth A] Focus chain EA [auth A] Focus chain FA [auth A] Focus chain H [auth U] Focus chain J [auth U] Focus chain K [auth U] Focus chain L [auth U] Focus chain M [auth U] Focus chain N [auth U] Focus chain O [auth U] Focus chain S [auth U] Focus chain U [auth A]
K Query on K Download Ideal Coordinates CCD File SDF format, chain IA [auth A] SDF format, chain JA [auth A] SDF format, chain KA [auth A] SDF format, chain LA [auth A] MOL2 format, chain IA [auth A] MOL2 format, chain JA [auth A] MOL2 format, chain KA [auth A] MOL2 format, chain LA [auth A] mmCIF format, chain IA [auth A] mmCIF format, chain JA [auth A] mmCIF format, chain KA [auth A] mmCIF format, chain LA [auth A]	IA [auth A], JA [auth A], KA [auth A], LA [auth A]	POTASSIUM ION K NPYPAHLBTDXSSS-UHFFFAOYSA-N		Interactions Focus chain IA [auth A] Focus chain JA [auth A] Focus chain KA [auth A] Focus chain LA [auth A] Interactions & Density Focus chain IA [auth A] Focus chain JA [auth A] Focus chain KA [auth A] Focus chain LA [auth A]