1AFR

STEAROYL-ACYL CARRIER PROTEIN DESATURASE FROM CASTOR SEEDS

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Structure Motif: Primary M-CSA Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1afra_	All alpha proteins	Ferritin-like	Ferritin-like	Ribonucleotide reductase-like	delta 9-stearoyl-acyl carrier protein desaturase	castor bean (Ricinus communis ) [TaxId: 3988 ],	SCOPe (2.08)
B	d1afrb_	All alpha proteins	Ferritin-like	Ferritin-like	Ribonucleotide reductase-like	delta 9-stearoyl-acyl carrier protein desaturase	castor bean (Ricinus communis ) [TaxId: 3988 ],	SCOPe (2.08)
C	d1afrc_	All alpha proteins	Ferritin-like	Ferritin-like	Ribonucleotide reductase-like	delta 9-stearoyl-acyl carrier protein desaturase	castor bean (Ricinus communis ) [TaxId: 3988 ],	SCOPe (2.08)
D	d1afrd_	All alpha proteins	Ferritin-like	Ferritin-like	Ribonucleotide reductase-like	delta 9-stearoyl-acyl carrier protein desaturase	castor bean (Ricinus communis ) [TaxId: 3988 ],	SCOPe (2.08)
E	d1afre_	All alpha proteins	Ferritin-like	Ferritin-like	Ribonucleotide reductase-like	delta 9-stearoyl-acyl carrier protein desaturase	castor bean (Ricinus communis ) [TaxId: 3988 ],	SCOPe (2.08)
F	d1afrf_	All alpha proteins	Ferritin-like	Ferritin-like	Ribonucleotide reductase-like	delta 9-stearoyl-acyl carrier protein desaturase	castor bean (Ricinus communis ) [TaxId: 3988 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Ribonucleotide reductase-like	8024660	4000846	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Ferritin-like	8037039	3001658	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Ferritin-like	8037039	3001658	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Ferritin-like	8037039	3001658	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Ferritin-like	8037039	3001658	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Ferritin-like	8037039	3001658	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Ferritin-like	8037039	3001658	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	FA_desaturase_2	e1afrA1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: Ferritin/Heme oxygenase	T: Heme oxygenase/Ribonucleotide reductase	F: FA_desaturase_2	ECOD (1.6)
B	FA_desaturase_2	e1afrB1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: Ferritin/Heme oxygenase	T: Heme oxygenase/Ribonucleotide reductase	F: FA_desaturase_2	ECOD (1.6)
C	FA_desaturase_2	e1afrC1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: Ferritin/Heme oxygenase	T: Heme oxygenase/Ribonucleotide reductase	F: FA_desaturase_2	ECOD (1.6)
D	FA_desaturase_2	e1afrD1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: Ferritin/Heme oxygenase	T: Heme oxygenase/Ribonucleotide reductase	F: FA_desaturase_2	ECOD (1.6)
E	FA_desaturase_2	e1afrE1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: Ferritin/Heme oxygenase	T: Heme oxygenase/Ribonucleotide reductase	F: FA_desaturase_2	ECOD (1.6)
F	FA_desaturase_2	e1afrF1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: Ferritin/Heme oxygenase	T: Heme oxygenase/Ribonucleotide reductase	F: FA_desaturase_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.620.20	Mainly Alpha	Orthogonal Bundle	Ribonucleotide Reductase, subunit A	Ribonucleotide Reductase, subunit A	CATH (4.3.0)
B	1.10.620.20	Mainly Alpha	Orthogonal Bundle	Ribonucleotide Reductase, subunit A	Ribonucleotide Reductase, subunit A	CATH (4.3.0)
C	1.10.620.20	Mainly Alpha	Orthogonal Bundle	Ribonucleotide Reductase, subunit A	Ribonucleotide Reductase, subunit A	CATH (4.3.0)
D	1.10.620.20	Mainly Alpha	Orthogonal Bundle	Ribonucleotide Reductase, subunit A	Ribonucleotide Reductase, subunit A	CATH (4.3.0)
E	1.10.620.20	Mainly Alpha	Orthogonal Bundle	Ribonucleotide Reductase, subunit A	Ribonucleotide Reductase, subunit A	CATH (4.3.0)
F	1.10.620.20	Mainly Alpha	Orthogonal Bundle	Ribonucleotide Reductase, subunit A	Ribonucleotide Reductase, subunit A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF03405	Fatty acid desaturase (FA_desaturase_2)	Fatty acid desaturase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	DELTA9 STEAROYL-ACYL CARRIER PROTEIN DESATURASE	oxidoreductase activity stearoyl-[ACP] desaturase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water catalytic activity cation binding ion binding binding metal ion binding small molecule binding	fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process carboxylic acid metabolic process lipid biosynthetic process primary metabolic process organic acid biosynthetic process organic acid metabolic process fatty acid biosynthetic process carboxylic acid biosynthetic process biosynthetic process small molecule metabolic process metabolic process fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process carboxylic acid metabolic process lipid biosynthetic process primary metabolic process organic acid biosynthetic process organic acid metabolic process fatty acid biosynthetic process carboxylic acid biosynthetic process biosynthetic process small molecule metabolic process metabolic process cellular process monocarboxylic acid metabolic process lipid metabolic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure plastid organelle cytoplasm intracellular membrane-bounded organelle chloroplast

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR009078	Ferritin-like superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR005067	Fatty acid desaturase, type 2	Family
A, B, C, D, E A, B, C, D, E, F	IPR005803	Fatty acid desaturase type 2, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F	IPR012348	Ribonucleotide reductase-like	Homologous Superfamily

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

Chains	Enzyme Name	Description	Catalytic Residues
A	acyl-[acyl-carrier-protein] desaturase M-CSA #136	Delta-9 stearoyl-acyl carrier protein desaturase (delta-9 desaturase) is a plastid-localised non-membrane-bound soluble desaturase that introduces the first double bond into saturated fatty acids, resulting in the corresponding mono-unsaturated fatty acids.	Defined by 9 residues: TRP:A-44 [auth A-62]GLU:A-87 [auth A-105]GLU:A-125 [auth A-143]HIS:A-128 [auth A-146]GLU:A-178 [auth A-196]THR:A-181 [auth A-199]ASP:A-210 [auth A-228]GLU:A-211 [auth A-229]HIS:A-214 [auth A-232] \| Explore in 3D: M-CSA Motif Definition Search M-CSA Motif EC: 1.14.99.6 (PDB Primary Data) Search M-CSA Motif + EC 1.14.99.6 EC: 1.14.19.2 (UniProt) Search M-CSA Motif + EC 1.14.19.2

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.