3CL5 | pdb_00003cl5

Structure of coronavirus hemagglutinin-esterase in complex with 4,9-O-diacetyl sialic acid

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Hema_esterase_2nd	e3cl5A4	A: beta sandwiches	X: jelly-roll	H: Viral protein domain (From Topology)	T: Viral protein domain	F: Hema_esterase_2nd	ECOD (1.6)
A	Hema_esterase_1st	e3cl5A3	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: SGNH hydrolase (From Topology)	T: SGNH hydrolase	F: Hema_esterase_1st	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02710	Hemagglutinin domain of haemagglutinin-esterase-fusion glycoprotein (Hema_HEFG)	Hemagglutinin domain of haemagglutinin-esterase-fusion glycoprotein	-	Family
A	PF03996	Hemagglutinin esterase (Hema_esterase)	Hemagglutinin esterase		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Hemagglutinin-esterase	hydrolase activity, acting on ester bonds short-chain carboxylesterase activity carboxylic ester hydrolase activity acetylesterase activity hydrolase activity sialate O-acetylesterase activity catalytic activity sialate 9-O-acetylesterase activity protein binding binding signaling receptor binding identical protein binding protein homodimerization activity protein dimerization activity hydrolase activity, acting on ester bonds short-chain carboxylesterase activity carboxylic ester hydrolase activity acetylesterase activity hydrolase activity sialate O-acetylesterase activity catalytic activity sialate 9-O-acetylesterase activity protein binding binding signaling receptor binding identical protein binding protein homodimerization activity protein dimerization activity sialate 4-O-acetylesterase activity host cell surface binding host cell surface receptor binding	virion attachment to host cell biological process involved in interspecies interaction between organisms receptor-mediated virion attachment to host cell adhesion of symbiont to host cell viral process viral life cycle adhesion of symbiont to host biological process involved in interaction with host biological process involved in symbiotic interaction membrane organization cellular component organization membrane fusion fusion of virus membrane with host plasma membrane cellular process virion attachment to host cell biological process involved in interspecies interaction between organisms receptor-mediated virion attachment to host cell adhesion of symbiont to host cell viral process viral life cycle adhesion of symbiont to host biological process involved in interaction with host biological process involved in symbiotic interaction membrane organization cellular component organization membrane fusion fusion of virus membrane with host plasma membrane cellular process cellular component organization or biogenesis membrane fusion involved in viral entry into host cell regulation of biological process negative regulation of immune system process immune system process biological regulation negative regulation of biological process regulation of immune system process	cellular anatomical structure membrane virion component virion membrane viral membrane viral envelope host cell plasma membrane host cellular component host cell part host cell membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR042545	Hemagglutinin-esterase	Family
A	IPR008980	Viral capsid/haemagglutinin protein	Homologous Superfamily
A	IPR003860	Haemagglutinin-esterase glycoprotein, haemagglutinin domain	Domain
A	IPR007142	Haemagglutinin-esterase glycoprotein, core	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.