Annotations: 5H2C

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Ank_2	e5h2cA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: Ank_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.40.20	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Ankyrin repeat-containing domain	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00023	Ankyrin repeat (Ank)	Ankyrin repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Oxysterol-binding protein homolog 1	sterol binding binding steroid binding lipid binding sterol transfer activity lipid transporter activity lipid transfer activity transporter activity	localization import into cell transport cellular process endocytosis establishment of localization vesicle-mediated transport catabolic process macroautophagy autophagy piecemeal microautophagy of the nucleus metabolic process microautophagy nucleophagy localization import into cell transport cellular process endocytosis establishment of localization vesicle-mediated transport catabolic process macroautophagy autophagy piecemeal microautophagy of the nucleus metabolic process microautophagy nucleophagy process utilizing autophagic mechanism maintenance of cell polarity establishment or maintenance of cell polarity secretion by cell exocytosis secretion export from cell macromolecule localization lipid localization lipid transport sterol transport organic hydroxy compound transport	nucleus-vacuole junction organelle membrane contact site cellular anatomical structure organelle membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system Golgi trans cisterna Golgi apparatus subcompartment nucleus-vacuole junction organelle membrane contact site cellular anatomical structure organelle membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system Golgi trans cisterna Golgi apparatus subcompartment Golgi apparatus organelle subcompartment Golgi cisterna Golgi stack cytoplasm cytosol cell periphery plasma membrane membrane perinuclear endoplasmic reticulum perinuclear region of cytoplasm endoplasmic reticulum endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network organelle membrane endoplasmic reticulum membrane early endosome endosome intracellular vesicle cytoplasmic vesicle vesicle nuclear outer membrane nuclear membrane organelle outer membrane bounding membrane of organelle outer membrane Golgi membrane vacuolar membrane vacuole
B	Nucleus-vacuole junction protein 1	structural molecule activity	cellular component biogenesis cellular component organization organelle localization by membrane tethering localization cellular component assembly organelle localization cellular process cellular component organization or biogenesis membrane docking nucleus-vacuole junction assembly primary metabolic process metabolic process lipid metabolic process protein localization cellular component biogenesis cellular component organization organelle localization by membrane tethering localization cellular component assembly organelle localization cellular process cellular component organization or biogenesis membrane docking nucleus-vacuole junction assembly primary metabolic process metabolic process lipid metabolic process protein localization cellular localization cellular macromolecule localization macromolecule localization catabolic process macroautophagy autophagy piecemeal microautophagy of the nucleus microautophagy nucleophagy process utilizing autophagic mechanism	membrane-bounded organelle nuclear outer membrane intracellular anatomical structure nuclear membrane membrane nucleus organelle outer membrane intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure bounding membrane of organelle organelle membrane-bounded organelle nuclear outer membrane intracellular anatomical structure nuclear membrane membrane nucleus organelle outer membrane intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure bounding membrane of organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network nuclear envelope outer membrane organelle membrane membrane-enclosed lumen intracellular organelle lumen organelle lumen nuclear periphery nuclear lumen nucleus-vacuole junction organelle membrane contact site

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001849	Pleckstrin homology domain	Domain
A	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
A	IPR002110	Ankyrin repeat	Repeat
A	IPR018494	Oxysterol-binding protein, conserved site	Conserved Site
A	IPR037239	Oxysterol-binding protein superfamily	Homologous Superfamily
A	IPR000648	Oxysterol-binding protein	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.