8XLJ

Structure of the native glutamine synthetase in the adult cortex and hippocampus

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	PF00120	Glutamine synthetase, catalytic domain (Gln-synt_C)	Glutamine synthetase, catalytic domain		Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	PF03951	Glutamine synthetase, beta-Grasp domain (Gln-synt_N)	Glutamine synthetase, beta-Grasp domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	Glutamine synthetase	cation binding transition metal ion binding ion binding binding nickel cation binding metal ion binding small molecule binding manganese ion binding acid-ammonia (or amide) ligase activity ammonia ligase activity glutamine synthetase activity catalytic activity ligase activity, forming carbon-nitrogen bonds ligase activity cation binding transition metal ion binding ion binding binding nickel cation binding metal ion binding small molecule binding manganese ion binding acid-ammonia (or amide) ligase activity ammonia ligase activity glutamine synthetase activity catalytic activity ligase activity, forming carbon-nitrogen bonds ligase activity magnesium ion binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding protein binding dynein light chain binding protein-cysteine S-acyltransferase activity catalytic activity, acting on a protein acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity protein-cysteine S-palmitoyltransferase activity S-acyltransferase activity palmitoyltransferase activity identical protein binding organic acid binding amino acid binding carboxylic acid binding glutamate binding	oxoacid metabolic process dicarboxylic acid metabolic process carboxylic acid metabolic process amino acid metabolic process primary metabolic process organic acid metabolic process alpha-amino acid metabolic process L-amino acid metabolic process glutamine family amino acid metabolic process proteinogenic amino acid metabolic process glutamate metabolic process metabolic process cellular process small molecule metabolic process oxoacid metabolic process dicarboxylic acid metabolic process carboxylic acid metabolic process amino acid metabolic process primary metabolic process organic acid metabolic process alpha-amino acid metabolic process L-amino acid metabolic process glutamine family amino acid metabolic process proteinogenic amino acid metabolic process glutamate metabolic process metabolic process cellular process small molecule metabolic process developmental process multicellular organismal process blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development anatomical structure morphogenesis multicellular organism development tube morphogenesis anatomical structure formation involved in morphogenesis anatomical structure development blood vessel development system development positive regulation of cell communication regulation of cellular process signaling modulation of chemical synaptic transmission synaptic transmission, glutamatergic positive regulation of biological process regulation of synaptic transmission, glutamatergic cell communication synaptic signaling positive regulation of cellular process trans-synaptic signaling regulation of signaling regulation of biological process biological regulation positive regulation of synaptic transmission cell-cell signaling positive regulation of synaptic transmission, glutamatergic chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication positive regulation of signaling cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis regulation of cell motility endothelial cell migration regulation of locomotion regulation of cell migration regulation of endothelial cell migration cell migration cell motility locomotion cell population proliferation regulation of sprouting angiogenesis regulation of developmental process regulation of vasculature development regulation of multicellular organismal process regulation of anatomical structure morphogenesis regulation of multicellular organismal development sprouting angiogenesis regulation of angiogenesis protein localization regulation of localization cellular localization regulation of protein localization regulation of protein localization to nucleus protein localization to nucleus localization protein localization to nucleolus regulation of cellular localization protein localization to organelle cellular macromolecule localization macromolecule localization regulation of protein localization to nucleolus positive regulation of cell population proliferation positive regulation of epithelial cell proliferation regulation of cell population proliferation regulation of epithelial cell proliferation epithelial cell proliferation glutamine family amino acid biosynthetic process organic acid biosynthetic process carboxylic acid biosynthetic process glutamine metabolic process small molecule biosynthetic process L-amino acid biosynthetic process amino acid biosynthetic process biosynthetic process proteinogenic amino acid biosynthetic process glutamine biosynthetic process alpha-amino acid biosynthetic process response to hexose response to monosaccharide response to carbohydrate response to stimulus response to glucose response to chemical response to oxygen-containing compound cellular response to stimulus cellular response to nutrient levels response to nutrient levels cellular response to stress response to stress response to starvation cellular response to starvation lipoprotein biosynthetic process lipoprotein metabolic process macromolecule biosynthetic process protein acylation protein lipidation protein palmitoylation macromolecule modification protein metabolic process macromolecule metabolic process protein modification process homeostatic process intracellular nitrogen homeostasis intracellular chemical homeostasis nitrogen utilization cellular homeostasis chemical homeostasis ammonia assimilation cycle establishment of protein localization nitrogen compound transport positive regulation of establishment of protein localization positive regulation of insulin secretion regulation of biological quality regulation of peptide hormone secretion regulation of hormone levels positive regulation of peptide hormone secretion establishment of protein localization to extracellular region protein secretion establishment of localization regulation of protein secretion regulation of secretion positive regulation of protein localization regulation of hormone secretion regulation of peptide secretion transport positive regulation of secretion by cell hormone secretion protein localization to extracellular region positive regulation of protein transport peptide secretion regulation of secretion by cell secretion by cell positive regulation of hormone secretion positive regulation of secretion amide transport signal release positive regulation of peptide secretion regulation of transport secretion regulation of peptide transport regulation of establishment of protein localization export from cell regulation of protein transport positive regulation of protein secretion peptide transport positive regulation of transport protein transport regulation of insulin secretion peptide hormone secretion hormone transport insulin secretion	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle somatodendritic compartment cell body perikaryon neuronal cell body myelin sheath cytosol membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle somatodendritic compartment cell body perikaryon neuronal cell body myelin sheath cytosol cell periphery plasma membrane membrane glial cell projection cell projection plasma membrane bounded cell projection protein-containing complex axon synapse neuron projection axon terminus presynapse distal axon cell junction neuron projection terminus endoplasmic reticulum endomembrane system

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR027303	Glutamine synthetase, glycine-rich site	Conserved Site
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR050292	Glutamine Synthetase	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR008146	Glutamine synthetase, catalytic domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR027302	Glutamine synthetase, N-terminal conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR014746	Glutamine synthetase/guanido kinase, catalytic domain	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR008147	Glutamine synthetase, N-terminal domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR036651	Glutamine synthetase, N-terminal domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.