8YW6 | pdb_00008yw6

Cryo-EM structure of apo human mitochondrial pyruvate carrier in the IMS-open conformation at pH 8.0

External Resource: Annotation

SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
B [auth C]	Heavy Chain	IGHV1	-	mitochondrial pyruvate carrier 2	SAbDab (2025-05-02)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B]	PF03650	Mitochondrial pyruvate carriers (MPC)	Mitochondrial pyruvate carriers	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B]	Mitochondrial pyruvate carrier 2	transporter activity pyruvate transmembrane transporter activity monocarboxylic acid transmembrane transporter activity carboxylic acid transmembrane transporter activity organic acid transmembrane transporter activity transmembrane transporter activity organic anion transmembrane transporter activity identical protein binding protein binding binding	organic acid transmembrane transport organic anion transport carboxylic acid transmembrane transport carboxylic acid transport transport mitochondrial pyruvate transmembrane transport mitochondrial transmembrane transport establishment of localization transmembrane transport organic acid transport pyruvate transport localization monocarboxylic acid transport pyruvate transmembrane transport organic acid transmembrane transport organic anion transport carboxylic acid transmembrane transport carboxylic acid transport transport mitochondrial pyruvate transmembrane transport mitochondrial transmembrane transport establishment of localization transmembrane transport organic acid transport pyruvate transport localization monocarboxylic acid transport pyruvate transmembrane transport cellular process mitochondrial transport oxoacid metabolic process thioester biosynthetic process acetyl-CoA metabolic process organic acid metabolic process nucleobase-containing compound metabolic process acyl-CoA metabolic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process acyl-CoA biosynthetic process phosphate-containing compound metabolic process sulfur compound metabolic process small molecule metabolic process amide metabolic process thioester metabolic process phosphorus metabolic process nucleoside phosphate metabolic process pyruvate metabolic process carboxylic acid metabolic process pyruvate decarboxylation to acetyl-CoA primary metabolic process amide biosynthetic process nucleobase-containing compound biosynthetic process purine-containing compound metabolic process acetyl-CoA biosynthetic process sulfur compound biosynthetic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process metabolic process monocarboxylic acid metabolic process protein localization cellular response to stimulus positive regulation of cell communication regulation of localization establishment of protein localization nitrogen compound transport regulation of cellular process response to stimulus positive regulation of establishment of protein localization cell communication carbohydrate homeostasis cellular macromolecule localization establishment of localization in cell positive regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of insulin secretion regulation of biological quality regulation of peptide hormone secretion regulation of biological process regulation of hormone levels positive regulation of peptide hormone secretion establishment of protein localization to extracellular region intracellular glucose homeostasis protein secretion cellular response to oxygen-containing compound regulation of protein secretion regulation of secretion cellular response to carbohydrate stimulus chemical homeostasis response to glucose response to chemical glucose homeostasis positive regulation of protein localization insulin secretion involved in cellular response to glucose stimulus cellular localization regulation of hormone secretion regulation of protein localization regulation of peptide secretion signaling homeostatic process positive regulation of biological process positive regulation of secretion by cell hormone secretion protein localization to extracellular region positive regulation of protein transport peptide secretion regulation of secretion by cell secretion by cell positive regulation of hormone secretion response to monosaccharide response to carbohydrate positive regulation of secretion amide transport signal release cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus positive regulation of cellular process positive regulation of peptide secretion regulation of signaling regulation of transport secretion regulation of peptide transport biological regulation regulation of establishment of protein localization export from cell cell-cell signaling response to oxygen-containing compound cellular response to glucose stimulus regulation of protein transport positive regulation of protein secretion peptide transport response to hexose cellular response to chemical stimulus cellular homeostasis positive regulation of transport protein transport regulation of cellular localization regulation of insulin secretion peptide hormone secretion macromolecule localization regulation of insulin secretion involved in cellular response to glucose stimulus hormone transport regulation of cell communication insulin secretion positive regulation of signaling	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane mitochondrial protein-containing complex protein-containing complex membrane protein complex inner mitochondrial membrane protein complex nucleus
B [auth C]	MPC specific nanobody 1	-	-	-
C [auth A]	Mitochondrial pyruvate carrier 1	transporter activity pyruvate transmembrane transporter activity monocarboxylic acid transmembrane transporter activity carboxylic acid transmembrane transporter activity organic acid transmembrane transporter activity transmembrane transporter activity organic anion transmembrane transporter activity	organic acid transmembrane transport organic anion transport carboxylic acid transmembrane transport carboxylic acid transport transport mitochondrial pyruvate transmembrane transport mitochondrial transmembrane transport establishment of localization transmembrane transport organic acid transport pyruvate transport localization monocarboxylic acid transport pyruvate transmembrane transport organic acid transmembrane transport organic anion transport carboxylic acid transmembrane transport carboxylic acid transport transport mitochondrial pyruvate transmembrane transport mitochondrial transmembrane transport establishment of localization transmembrane transport organic acid transport pyruvate transport localization monocarboxylic acid transport pyruvate transmembrane transport cellular process mitochondrial transport	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane mitochondrial protein-containing complex protein-containing complex membrane protein complex inner mitochondrial membrane protein complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B]	IPR005336	Mitochondrial pyruvate carrier	Family
C [auth A]	IPR005336	Mitochondrial pyruvate carrier	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth B]	Pharos: O95563	astrocytic tumor large cell medulloblastoma malignant glioma osteosarcoma Pick disease primitive neuroectodermal tumor ulcerative colitis atypical teratoid rhabdoid tumor lung cancer medulloblastoma pancreatic ductal adenocarcinoma pilocytic astrocytoma schizophrenia glioblastoma malignant ependymoma astrocytic tumor large cell medulloblastoma malignant glioma osteosarcoma Pick disease primitive neuroectodermal tumor ulcerative colitis atypical teratoid rhabdoid tumor lung cancer medulloblastoma pancreatic ductal adenocarcinoma pilocytic astrocytoma schizophrenia glioblastoma malignant ependymoma oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm plasma cell myeloma Sjogren syndrome
C [auth A]	Pharos: Q9Y5U8	mitochondrial pyruvate carrier deficiency substance dependence Substance-Related Disorders lung adenocarcinoma malignant pancreatic neoplasm pancreatic ductal adenocarcinoma substance abuse drug dependence gastric carcinoma lung cancer medulloblastoma plasma cell myeloma substance-related disorder large cell medulloblastoma malignant mesothelioma mitochondrial pyruvate carrier deficiency substance dependence Substance-Related Disorders lung adenocarcinoma malignant pancreatic neoplasm pancreatic ductal adenocarcinoma substance abuse drug dependence gastric carcinoma lung cancer medulloblastoma plasma cell myeloma substance-related disorder large cell medulloblastoma malignant mesothelioma ovarian cancer

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A [auth B], C [auth A]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A [auth B], C [auth A]	MemProtMD	Annotated as membrane protein by MemProtMD

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.