8VSO | pdb_00008vso

Ternary structure of 14-3-3 sigma, BRAF phosphopeptide (pS365) and compound 78 (1124378)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth B]	SCOP2B Superfamily	14-3-3 protein	8082819	3001329	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B]	PF00244	14-3-3 protein (14-3-3)	14-3-3 protein	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B]	14-3-3 protein sigma	phosphoprotein binding protein binding binding phosphoserine residue binding protein phosphorylated amino acid binding protein serine/threonine kinase activity enzyme regulator activity catalytic activity, acting on a protein diacylglycerol-dependent serine/threonine kinase activity kinase activity protein kinase activity transferase activity enzyme inhibitor activity protein kinase C inhibitor activity phosphoprotein binding protein binding binding phosphoserine residue binding protein phosphorylated amino acid binding protein serine/threonine kinase activity enzyme regulator activity catalytic activity, acting on a protein diacylglycerol-dependent serine/threonine kinase activity kinase activity protein kinase activity transferase activity enzyme inhibitor activity protein kinase C inhibitor activity protein kinase regulator activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein kinase inhibitor activity molecular function inhibitor activity molecular function regulator activity catalytic activity protein serine/threonine kinase inhibitor activity kinase inhibitor activity kinase regulator activity molecular sequestering activity protein sequestering activity kinase binding enzyme binding protein kinase binding cell adhesion molecule binding cadherin binding identical protein binding	regulation of growth regulation of biological process regulation of cellular process regulation of cellular component organization biological regulation growth positive regulation of biological process positive regulation of cell growth regulation of cell growth cell growth cellular component organization positive regulation of growth cellular process cellular component organization or biogenesis regulation of growth regulation of biological process regulation of cellular process regulation of cellular component organization biological regulation growth positive regulation of biological process positive regulation of cell growth regulation of cell growth cell growth cellular component organization positive regulation of growth cellular process cellular component organization or biogenesis positive regulation of cellular process protein localization localization cellular localization cellular macromolecule localization macromolecule localization regulation of localization regulation of protein localization negative regulation of biological process negative regulation of protein localization to plasma membrane negative regulation of cellular process regulation of protein localization to membrane negative regulation of protein localization protein localization to cell periphery protein localization to plasma membrane regulation of protein localization to cell periphery localization within membrane protein localization to membrane negative regulation of protein localization to membrane regulation of cellular localization negative regulation of protein localization to cell periphery regulation of protein localization to plasma membrane establishment of protein localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport intracellular transport protein export from nucleus establishment of localization protein transport establishment of localization in cell nuclear export intracellular protein transport epidermal cell division cell division regulation of epidermal cell division regulation of cell division developmental process establishment of skin barrier epithelium development skin development skin epidermis development epidermis development anatomical structure development animal organ development tissue development regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms negative regulation of response to biotic stimulus response to stimulus regulation of response to external stimulus response to biotic stimulus response to stress regulation of response to stress innate immune response regulation of immune system process response to external biotic stimulus negative regulation of response to stimulus immune response response to other organism defense response regulation of innate immune response negative regulation of immune response defense response to symbiont response to external stimulus regulation of response to stimulus negative regulation of immune system process immune system process defense response to other organism negative regulation of response to external stimulus negative regulation of defense response regulation of immune response negative regulation of innate immune response cell population proliferation epithelial cell proliferation keratinocyte proliferation cell adhesion cell-cell adhesion regulation of cell adhesion regulation of cell-cell adhesion cellular response to stimulus signaling signal transduction cell communication negative regulation of cell population proliferation regulation of stem cell proliferation negative regulation of stem cell proliferation stem cell proliferation regulation of cell population proliferation positive regulation of cell adhesion regulation of protein modification process regulation of catalytic activity regulation of protein phosphorylation negative regulation of phosphate metabolic process negative regulation of catalytic activity regulation of transferase activity regulation of primary metabolic process negative regulation of kinase activity negative regulation of transferase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process protein metabolic process phosphorus metabolic process protein modification process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process negative regulation of metabolic process negative regulation of molecular function primary metabolic process negative regulation of protein kinase activity regulation of protein kinase activity regulation of macromolecule metabolic process regulation of molecular function regulation of kinase activity negative regulation of protein phosphorylation macromolecule modification negative regulation of phosphorus metabolic process regulation of phosphorylation regulation of phosphorus metabolic process metabolic process macromolecule metabolic process negative regulation of phosphorylation regulation of metabolic process positive regulation of nucleocytoplasmic transport positive regulation of establishment of protein localization positive regulation of protein transport positive regulation of intracellular transport regulation of protein export from nucleus regulation of intracellular transport regulation of transport regulation of establishment of protein localization regulation of nucleocytoplasmic transport regulation of protein transport positive regulation of protein export from nucleus positive regulation of transport positive regulation of protein localization regulation of intracellular protein transport positive regulation of intracellular protein transport cell death intracellular signal transduction apoptotic signaling pathway cellular response to stress DNA damage response intrinsic apoptotic signaling pathway in response to DNA damage apoptotic process intrinsic apoptotic signaling pathway programmed cell death cAMP/PKA signal transduction intracellular signaling cassette multicellular organismal process keratinization epidermal cell differentiation cellular developmental process epithelial cell differentiation cell differentiation keratinocyte differentiation keratinocyte development cell development epithelial cell development regulation of keratinocyte proliferation negative regulation of keratinocyte proliferation regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation cell cycle regulation of cell cycle RNA metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process apoptotic mitochondrial changes release of cytochrome c from mitochondria organelle organization mitochondrion organization regulation of developmental process regulation of epidermal cell differentiation regulation of cell differentiation regulation of epithelial cell differentiation positive regulation of developmental process multicellular organism development positive regulation of cell differentiation regulation of multicellular organismal process regulation of multicellular organismal development positive regulation of epidermis development positive regulation of epithelial cell differentiation regulation of epidermis development positive regulation of epidermal cell differentiation	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol intracellular organelle extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol intracellular organelle nucleus intracellular membrane-bounded organelle
B [auth P]	Serine/threonine-protein kinase B-raf phosphopeptide	protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity DNA-dependent protein kinase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity DNA-dependent protein kinase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein-containing complex binding MAP kinase kinase activity protein serine/threonine/tyrosine kinase activity histone H3T6 kinase activity histone H3 kinase activity histone modifying activity histone kinase activity histone H3S57 kinase activity cation binding calcium ion binding metal ion binding scaffold protein binding protein binding histone H4S1 kinase activity histone H4 kinase activity histone H3T11 kinase activity histone H3S28 kinase activity histone H2B kinase activity histone H2BS36 kinase activity ribosomal protein S6 kinase activity histone H3S10 kinase activity histone H2AS121 kinase activity histone H2A kinase activity AMP-activated protein kinase activity kinase binding enzyme binding protein kinase binding mitogen-activated protein kinase kinase binding MAP kinase kinase kinase activity histone H3T45 kinase activity eukaryotic translation initiation factor 2alpha kinase activity histone H3T3 kinase activity histone H2BS14 kinase activity identical protein binding Rho-dependent protein serine/threonine kinase activity histone H2AT120 kinase activity histone H2AXS139 kinase activity histone H2AX kinase activity protein serine kinase activity 3-phosphoinositide-dependent protein kinase activity transition metal ion binding zinc ion binding histone H2AS1 kinase activity	regulation of localization regulated exocytosis regulation of cellular process synaptic vesicle cycle negative regulation of biological process synaptic vesicle exocytosis negative regulation of transport vesicle-mediated transport cell communication vesicle-mediated transport in synapse localization negative regulation of secretion establishment of localization in cell negative regulation of secretion by cell regulation of localization regulated exocytosis regulation of cellular process synaptic vesicle cycle negative regulation of biological process synaptic vesicle exocytosis negative regulation of transport vesicle-mediated transport cell communication vesicle-mediated transport in synapse localization negative regulation of secretion establishment of localization in cell negative regulation of secretion by cell trans-synaptic signaling regulation of biological process neurotransmitter secretion regulation of synaptic vesicle exocytosis neurotransmitter transport establishment of localization negative regulation of synaptic vesicle exocytosis regulation of secretion signal release from synapse regulation of trans-synaptic signaling exocytosis cellular localization transport modulation of chemical synaptic transmission signaling negative regulation of regulated secretory pathway regulation of regulated secretory pathway synaptic signaling regulation of secretion by cell secretion by cell negative regulation of exocytosis signal release negative regulation of cellular process regulation of signaling regulation of transport secretion regulation of neurotransmitter transport biological regulation export from cell cell-cell signaling regulation of vesicle-mediated transport chemical synaptic transmission regulation of neurotransmitter secretion anterograde trans-synaptic signaling regulation of exocytosis regulation of cell communication cellular process developmental process anatomical structure morphogenesis head development anatomical structure development head morphogenesis body morphogenesis cell adhesion substrate adhesion-dependent cell spreading cell-substrate adhesion positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of biological process regulation of peptidyl-serine phosphorylation positive regulation of phosphate metabolic process peptidyl-serine modification regulation of primary metabolic process positive regulation of metabolic process positive regulation of protein modification process peptidyl-serine phosphorylation regulation of phosphate metabolic process phosphate-containing compound metabolic process peptidyl-amino acid modification positive regulation of macromolecule metabolic process protein metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process positive regulation of cellular process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process positive regulation of peptidyl-serine phosphorylation macromolecule modification regulation of phosphorus metabolic process metabolic process regulation of phosphorylation macromolecule metabolic process regulation of metabolic process positive regulation of substrate adhesion-dependent cell spreading regulation of cell-substrate adhesion positive regulation of cell adhesion regulation of substrate adhesion-dependent cell spreading regulation of cell adhesion positive regulation of cell-substrate adhesion multicellular organismal process regulation of leukocyte differentiation cellular developmental process regulation of developmental process regulation of leukocyte activation cell development regulation of cell activation mononuclear cell differentiation regulation of cell differentiation lymphocyte activation lymphocyte differentiation regulation of cell development leukocyte activation regulation of T cell differentiation multicellular organism development T cell activation cell differentiation T cell differentiation regulation of immune system process regulation of multicellular organismal process regulation of lymphocyte differentiation regulation of multicellular organismal development hemopoiesis cell activation regulation of T cell activation immune system process regulation of hemopoiesis leukocyte differentiation regulation of lymphocyte activation cellular response to stimulus cellular response to metal ion cellular response to chemical stimulus response to stimulus response to metal ion response to chemical cellular response to calcium ion response to calcium ion somatic stem cell population maintenance maintenance of cell number stem cell population maintenance cellular response to xenobiotic stimulus response to xenobiotic stimulus response to organophosphorus response to oxygen-containing compound response to nitrogen compound response to purine-containing compound response to cAMP positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of signaling thyroid gland development endocrine system development gland development animal organ development system development negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process apoptotic process programmed cell death myeloid progenitor cell differentiation hematopoietic progenitor cell differentiation cell population proliferation regulation of cell population proliferation negative regulation of endothelial cell apoptotic process endothelial cell apoptotic process regulation of endothelial cell apoptotic process CD4-positive, alpha-beta T cell differentiation alpha-beta T cell differentiation CD4-positive, alpha-beta T cell activation alpha-beta T cell activation positive regulation of organelle organization regulation of cytoskeleton organization regulation of cellular component organization regulation of actin filament-based process positive regulation of cellular component organization regulation of actin filament bundle assembly cellular component biogenesis cellular component organization cellular component assembly positive regulation of actin filament bundle assembly actin filament bundle organization positive regulation of stress fiber assembly actin filament-based process cellular component organization or biogenesis stress fiber assembly regulation of actin filament organization actin cytoskeleton organization actomyosin structure organization positive regulation of cellular component biogenesis positive regulation of cytoskeleton organization actin filament organization regulation of cellular component biogenesis positive regulation of supramolecular fiber organization regulation of organelle organization regulation of stress fiber assembly organelle organization contractile actin filament bundle assembly regulation of actomyosin structure organization regulation of actin cytoskeleton organization actin filament bundle assembly regulation of supramolecular fiber organization supramolecular fiber organization cytoskeleton organization cell projection organization positive regulation of neuron projection regeneration regulation of cellular response to stress neuron projection development regeneration neuron projection regeneration positive regulation of developmental process neuron differentiation positive regulation of cell projection organization response to wounding positive regulation of response to wounding regulation of axon regeneration regulation of cell projection organization response to external stimulus nervous system development generation of neurons regulation of neuron projection regeneration regulation of neuron projection development regulation of response to external stimulus response to axon injury regulation of response to wounding neurogenesis positive regulation of response to external stimulus cellular response to stress axon regeneration positive regulation of neuron projection development regulation of response to stress response to stress plasma membrane bounded cell projection organization axon development neuron development positive regulation of axon regeneration regulation of plasma membrane bounded cell projection organization CD4-positive or CD8-positive, alpha-beta T cell lineage commitment T cell lineage commitment positive T cell selection T cell selection cell fate commitment regulation of biosynthetic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process positive regulation of nervous system development axonogenesis regulation of neurogenesis cell projection morphogenesis neuron projection morphogenesis positive regulation of cell development positive regulation of multicellular organismal process plasma membrane bounded cell projection morphogenesis cell morphogenesis regulation of nervous system development positive regulation of cell differentiation regulation of axonogenesis positive regulation of neurogenesis positive regulation of axonogenesis regulation of anatomical structure morphogenesis cell morphogenesis involved in neuron differentiation cellular response to endogenous stimulus cellular response to growth factor stimulus response to endogenous stimulus cellular response to nerve growth factor stimulus response to nerve growth factor response to growth factor T cell differentiation in thymus postsynaptic modulation of chemical synaptic transmission cell surface receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway ERBB signaling pathway epidermal growth factor receptor signaling pathway enzyme-linked receptor protein signaling pathway negative regulation of locomotion regulation of cell motility regulation of fibroblast migration fibroblast migration negative regulation of fibroblast migration regulation of locomotion ameboidal-type cell migration regulation of cell migration negative regulation of cell motility cell migration cell motility negative regulation of cell migration locomotion face development response to hormone response to peptide hormone immune response-regulating cell surface receptor signaling pathway immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response positive regulation of immune system process immune response-activating cell surface receptor signaling pathway immune response T cell receptor signaling pathway regulation of immune response antigen receptor-mediated signaling pathway activation of immune response immune system development hematopoietic or lymphoid organ development thymus development animal organ morphogenesis response to light stimulus system process learning learning or memory nervous system process visual learning visual behavior cognition associative learning behavior response to radiation response to abiotic stimulus neuron apoptotic process negative regulation of neuron apoptotic process regulation of neuron apoptotic process protein localization establishment of protein localization establishment of protein localization to membrane localization within membrane protein localization to membrane cellular macromolecule localization macromolecule localization hexose transmembrane transport carbohydrate transport positive regulation of D-glucose transmembrane transport transmembrane transport regulation of transmembrane transport positive regulation of transport D-glucose transmembrane transport positive regulation of transmembrane transport regulation of D-glucose transmembrane transport monosaccharide transmembrane transport carbohydrate transmembrane transport long-term synaptic potentiation regulation of biological quality regulation of synaptic plasticity positive regulation of synaptic transmission	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell body membrane-bounded organelle intracellular membraneless organelle cilium plasma membrane bounded cell projection intracellular organelle ciliary basal body cell projection microtubule organizing center cytoskeleton cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell body membrane-bounded organelle intracellular membraneless organelle cilium plasma membrane bounded cell projection intracellular organelle ciliary basal body cell projection microtubule organizing center cytoskeleton organelle membraneless organelle microtubule cytoskeleton cell periphery plasma membrane membrane intracellular membrane-bounded organelle synapse cell junction glutamatergic synapse neuron projection postsynapse mitochondrion centrosome centriolar satellite presynapse nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B]	IPR023409	14-3-3 protein, conserved site	Conserved Site
A [auth B]	IPR023410	14-3-3 domain	Domain
A [auth B]	IPR037435	14-3-3 protein sigma	Family
A [auth B]	IPR036815	14-3-3 domain superfamily	Homologous Superfamily
A [auth B]	IPR000308	14-3-3 protein	Family
B [auth P]	IPR020454	Diacylglycerol/phorbol-ester binding	Domain
B [auth P]	IPR000719	Protein kinase domain	Domain
B [auth P]	IPR017441	Protein kinase, ATP binding site	Binding Site
B [auth P]	IPR051681	Serine/Threonine Kinases and Pseudokinases	Family
B [auth P]	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain
B [auth P]	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	Domain
B [auth P]	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
B [auth P]	IPR046349	C1-like domain superfamily	Homologous Superfamily
B [auth P]	IPR008271	Serine/threonine-protein kinase, active site	Active Site
B [auth P]	IPR003116	Raf-like Ras-binding	Domain
B [auth P]	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth B]	Pharos: P31947	esophageal squamous cell carcinoma squamous cell carcinoma esophageal cancer Lymphatic Metastasis keloid lung adenocarcinoma malignant pancreatic neoplasm non-small cell lung carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm sarcoidosis cystic fibrosis interstitial cystitis malignant mesothelioma oral cavity neoplasm esophageal squamous cell carcinoma squamous cell carcinoma esophageal cancer Lymphatic Metastasis keloid lung adenocarcinoma malignant pancreatic neoplasm non-small cell lung carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm sarcoidosis cystic fibrosis interstitial cystitis malignant mesothelioma oral cavity neoplasm pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia spina bifida atypical teratoid rhabdoid tumor diabetes mellitus malignant ependymoma neoplasm of esophagus osteosarcoma pancreatic intraductal papillary-mucinous carcinoma psoriasis breast cancer ductal breast carcinoma in situ hepatocellular carcinoma large cell medulloblastoma lung cancer malignant glioma
B [auth P]	Pharos: P15056	cardiofaciocutaneous syndrome Noonan syndrome Noonan syndrome with multiple lentigines malignant glioma colorectal cancer Noonan syndrome 7 gastrointestinal stromal tumor Costello syndrome Erdheim-Chester disease melanoma craniopharyngioma pilocytic astrocytoma ameloblastoma cancer hairy cell leukemia cardiofaciocutaneous syndrome Noonan syndrome Noonan syndrome with multiple lentigines malignant glioma colorectal cancer Noonan syndrome 7 gastrointestinal stromal tumor Costello syndrome Erdheim-Chester disease melanoma craniopharyngioma pilocytic astrocytoma ameloblastoma cancer hairy cell leukemia adrenal cortex carcinoma subependymal giant cell astrocytoma LEOPARD syndrome 3 lung cancer astrocytic tumor cardiomyopathy hepatocellular carcinoma protoplasmic astrocytoma mixed glioma Neoplasms, Experimental fibrillary astrocytoma childhood cerebral astrocytoma plasma cell myeloma intellectual disability adamantinous craniopharyngioma prostate cancer juvenile pilocytic astrocytoma Sezary syndrome Langerhans cell histiocytosis anaplastic astrocytoma cutaneous melanoma neuroendocrine neoplasm thyroid gland carcinoma cardiofaciocutaneous syndrome 1 gemistocytic astrocytoma Hashimoto-Pritzker syndrome cholangiocarcinoma papillary craniopharyngioma primary cutaneous T-cell non-Hodgkin lymphoma thyroid adenoma liver cancer Noonan syndrome 1 gastric neoplasm oligodendroglioma glioblastoma granulomatous slack skin disease childhood brain stem glioma ovarian carcinoma chronic myelogenous leukemia, BCR-ABL1 positive hypertrophic cardiomyopathy adamantinoma mandibular cancer prostate adenocarcinoma adrenal carcinoma congenital anemia kidney neoplasm stomach carcinoma in situ large congenital melanocytic nevus astrocytoma (excluding glioblastoma) thyroid cancer benign neoplasm of stomach lung benign neoplasm breast adenocarcinoma non-Hodgkin lymphoma nongerminomatous germ cell tumor type 2 diabetes mellitus malignant colon neoplasm cerebral astrocytoma osteosarcoma glioma ovarian neoplasm histiocytosis colon carcinoma colorectal carcinoma psoriasis atypical teratoid rhabdoid tumor thyroid cancer, nonmedullary, 1 liver neoplasm breast carcinoma non-Langerhans cell histiocytosis familial nonmedullary thyroid carcinoma tuberculosis lymphoma, non-Hodgkin, familial gastric carcinoma malignant ependymoma Charcot-Marie-Tooth disease ovarian cancer hydrops fetalis colorectal adenocarcinoma interstitial cystitis kidney cancer renal cell carcinoma spina bifida large cell medulloblastoma cystadenoma B-cell chronic lymphocytic leukemia diffuse astrocytoma thyroid cancer, nonmedullary, 2 lung adenocarcinoma neurofibromatosis type 1 exocrine pancreatic carcinoma thyroid gland papillary carcinoma lung carcinoma non-small cell lung carcinoma

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
B [auth P]	SEP	Parent Component: SER RESID: AA0037 PSI-MOD : O-phospho-L-serine MOD:00046

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.