Annotations: 9B7A

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Peroxiredoxin-1	peroxidase activity oxidoreductase activity antioxidant activity oxidoreductase activity, acting on peroxide as acceptor catalytic activity RNA binding binding organic cyclic compound binding nucleic acid binding thioredoxin-dependent peroxiredoxin activity thioredoxin peroxidase activity peroxiredoxin activity cell adhesion molecule binding cadherin binding peroxidase activity oxidoreductase activity antioxidant activity oxidoreductase activity, acting on peroxide as acceptor catalytic activity RNA binding binding organic cyclic compound binding nucleic acid binding thioredoxin-dependent peroxiredoxin activity thioredoxin peroxidase activity peroxiredoxin activity cell adhesion molecule binding cadherin binding protein binding identical protein binding	catabolic process hydrogen peroxide metabolic process reactive oxygen species metabolic process metabolic process cellular process hydrogen peroxide catabolic process cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation canonical NF-kappaB signal transduction intracellular signal transduction catabolic process hydrogen peroxide metabolic process reactive oxygen species metabolic process metabolic process cellular process hydrogen peroxide catabolic process cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation canonical NF-kappaB signal transduction intracellular signal transduction cell communication intracellular signaling cassette signal transduction cellular response to oxidative stress detoxification cellular response to chemical stress response to superoxide cellular oxidant detoxification cellular response to oxygen radical cellular response to reactive oxygen species cellular response to stress response to stress cellular detoxification response to oxygen-containing compound cellular response to oxygen-containing compound response to reactive oxygen species response to toxic substance removal of superoxide radicals superoxide metabolic process response to oxidative stress cellular response to chemical stimulus response to chemical cellular response to superoxide cellular response to toxic substance response to oxygen radical multicellular organismal process immune system process cell activation leukocyte activation developmental process multicellular organism development skeletal system development anatomical structure development system development cell population proliferation multicellular organismal-level homeostasis homeostatic process homeostasis of number of cells myeloid cell homeostasis erythrocyte homeostasis regulation of cellular response to stress regulation of signal transduction stress-activated MAPK cascade regulation of intracellular signal transduction regulation of response to stress regulation of signaling regulation of stress-activated protein kinase signaling cascade regulation of MAPK cascade regulation of stress-activated MAPK cascade stress-activated protein kinase signaling cascade regulation of response to stimulus MAPK cascade regulation of cell communication non-canonical NF-kappaB signal transduction regulation of non-canonical NF-kappaB signal transduction lymphocyte mediated immunity biological process involved in interspecies interaction between organisms immune response response to other organism defense response defense response to symbiont response to external stimulus leukocyte mediated cytotoxicity response to biotic stimulus immune effector process defense response to other organism natural killer cell mediated cytotoxicity innate immune response leukocyte mediated immunity response to external biotic stimulus natural killer cell mediated immunity cell killing fibroblast proliferation natural killer cell activation lymphocyte activation cell redox homeostasis cellular homeostasis	membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle intracellular membrane-bounded organelle intracellular organelle melanosome cellular anatomical structure cytoplasmic vesicle organelle cytoplasm vesicle extracellular exosome extracellular vesicle membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle intracellular membrane-bounded organelle intracellular organelle melanosome cellular anatomical structure cytoplasmic vesicle organelle cytoplasm vesicle extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle cytosol nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR019479	Peroxiredoxin, C-terminal	Domain
A, B	IPR024706	Peroxiredoxin, AhpC-type	Family
A, B	IPR050217	Thiol-specific antioxidant peroxiredoxin	Family
A, B	IPR013766	Thioredoxin domain	Domain
A, B	IPR036249	Thioredoxin-like superfamily	Homologous Superfamily
A, B	IPR000866	Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q06830	schistosomiasis esophageal squamous cell carcinoma non-small cell lung carcinoma asbestosis keloid methylmalonic acidemia with homocystinuria Liver Neoplasms, Experimental pancreatic intraductal papillary-mucinous carcinoma lung benign neoplasm lymphoplasmacytic lymphoma medulloblastoma ovarian cancer plasma cell myeloma chronic obstructive pulmonary disease hepatocellular carcinoma schistosomiasis esophageal squamous cell carcinoma non-small cell lung carcinoma asbestosis keloid methylmalonic acidemia with homocystinuria Liver Neoplasms, Experimental pancreatic intraductal papillary-mucinous carcinoma lung benign neoplasm lymphoplasmacytic lymphoma medulloblastoma ovarian cancer plasma cell myeloma chronic obstructive pulmonary disease hepatocellular carcinoma intestinal schistosomiasis lung cancer pancreatic ductal adenocarcinoma invasive ductal breast carcinoma malignant pancreatic neoplasm

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.