9B89 | pdb_00009b89

Cryo-EM structure of human ADAR1 in complex with dsRNA derived from HT2C gene in the pre-editing state

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02137	Adenosine-deaminase (editase) domain (A_deamin)	Adenosine-deaminase (editase) domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Maltodextrin-binding protein,Double-stranded RNA-specific adenosine deaminase	transporter activity carbohydrate transmembrane transporter activity transmembrane transporter activity oligosaccharide binding binding disaccharide binding carbohydrate binding maltose binding RNA binding double-stranded RNA binding nucleic acid binding DNA binding hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines adenosine deaminase activity transporter activity carbohydrate transmembrane transporter activity transmembrane transporter activity oligosaccharide binding binding disaccharide binding carbohydrate binding maltose binding RNA binding double-stranded RNA binding nucleic acid binding DNA binding hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines adenosine deaminase activity hydrolase activity catalytic activity deaminase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds double-stranded RNA adenosine deaminase activity tRNA-specific adenosine deaminase activity cation binding ion binding metal ion binding small molecule binding	localization transport carbohydrate transport oligosaccharide transport disaccharide transport establishment of localization maltose transport polysaccharide localization dextrin transport macromolecule localization maltodextrin transmembrane transport polysaccharide transport RNA metabolic process primary metabolic process localization transport carbohydrate transport oligosaccharide transport disaccharide transport establishment of localization maltose transport polysaccharide localization dextrin transport macromolecule localization maltodextrin transmembrane transport polysaccharide transport RNA metabolic process primary metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA modification adenosine to inosine editing base conversion or substitution editing macromolecule modification metabolic process cellular process macromolecule metabolic process regulation of cellular process negative regulation of biological process positive regulation of biological process positive regulation of macromolecule biosynthetic process post-transcriptional regulation of gene expression positive regulation of metabolic process negative regulation of post-transcriptional gene silencing by regulatory ncRNA regulation of gene silencing by regulatory ncRNA positive regulation of biosynthetic process negative regulation of cellular process regulation of post-transcriptional gene silencing by regulatory ncRNA positive regulation of macromolecule metabolic process positive regulation of cellular process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process negative regulation of metabolic process negative regulation of gene silencing by regulatory ncRNA biological regulation regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulatory ncRNA-mediated post-transcriptional gene silencing regulatory ncRNA-mediated gene silencing regulation of gene expression negative regulation of gene expression biosynthetic process regulation of post-transcriptional gene silencing negative regulation of biosynthetic process positive regulation of gene expression negative regulation of macromolecule biosynthetic process post-transcriptional gene silencing regulation of macromolecule biosynthetic process negative regulation of post-transcriptional gene silencing regulation of metabolic process immune system development developmental process multicellular organism development multicellular organismal process immune system process somatic diversification of immune receptors via somatic mutation anatomical structure development somatic diversification of immune receptors system development regulation of protein modification process regulation of catalytic activity regulation of protein phosphorylation negative regulation of phosphate metabolic process negative regulation of catalytic activity regulation of transferase activity regulation of primary metabolic process negative regulation of kinase activity negative regulation of transferase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process protein metabolic process phosphorus metabolic process protein modification process negative regulation of protein metabolic process protein phosphorylation phosphorylation negative regulation of protein kinase activity by regulation of protein phosphorylation regulation of protein metabolic process negative regulation of molecular function negative regulation of protein kinase activity regulation of protein kinase activity regulation of molecular function regulation of kinase activity negative regulation of protein phosphorylation negative regulation of phosphorus metabolic process regulation of phosphorylation regulation of phosphorus metabolic process negative regulation of phosphorylation cellular developmental process ossification cell differentiation osteoblast differentiation protein localization cellular localization establishment of protein localization nitrogen compound transport nucleocytoplasmic transport nuclear transport intracellular transport protein export from nucleus protein transport establishment of localization in cell cellular macromolecule localization nuclear export intracellular protein transport cellular response to stimulus response to stimulus regulation of type I interferon-mediated signaling pathway response to cytokine regulation of signal transduction response to biotic stimulus cell communication interferon-mediated signaling pathway cellular response to type I interferon cellular response to cytokine stimulus regulation of immune system process signal transduction immune response response to other organism regulation of innate immune response negative regulation of immune response response to external stimulus regulation of response to cytokine stimulus negative regulation of response to cytokine stimulus regulation of response to stimulus response to chemical defense response to other organism negative regulation of response to external stimulus negative regulation of defense response regulation of immune response response to type I interferon regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus negative regulation of response to biotic stimulus negative regulation of signaling signaling negative regulation of cell communication cytokine-mediated signaling pathway response to stress regulation of response to stress innate immune response response to external biotic stimulus regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus defense response regulation of cytokine-mediated signaling pathway defense response to symbiont negative regulation of signal transduction response to peptide negative regulation of immune system process negative regulation of cytokine-mediated signaling pathway type I interferon-mediated signaling pathway regulation of cell communication negative regulation of type I interferon-mediated signaling pathway negative regulation of innate immune response pre-miRNA processing RNA biosynthetic process nucleic acid biosynthetic process RNA processing nucleobase-containing compound biosynthetic process regulatory ncRNA processing miRNA processing protein localization to nucleus import into nucleus establishment of protein localization to organelle protein localization to organelle protein import into nucleus negative regulation of hepatocyte apoptotic process regulation of epithelial cell apoptotic process negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death epithelial cell apoptotic process negative regulation of apoptotic process regulation of hepatocyte apoptotic process negative regulation of epithelial cell apoptotic process hepatocyte apoptotic process apoptotic process programmed cell death mRNA processing mRNA metabolic process ribonucleoprotein complex biogenesis RISC complex assembly protein-RNA complex assembly cellular component organization cellular component biogenesis protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization positive regulation of viral genome replication positive regulation of viral process viral life cycle regulation of viral life cycle regulation of viral process viral genome replication viral process regulation of viral genome replication multicellular organismal-level homeostasis homeostatic process hematopoietic stem cell homeostasis homeostasis of number of cells hemopoiesis cell development erythrocyte differentiation myeloid cell differentiation myeloid cell homeostasis erythrocyte homeostasis response to virus definitive hemopoiesis response to interferon-alpha hematopoietic progenitor cell differentiation defense response to virus cellular response to virus	ATPase dependent transmembrane transport complex ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex transporter complex ATP-binding cassette (ABC) transporter complex cell periphery cellular anatomical structure transmembrane transporter complex outer membrane-bounded periplasmic space cell envelope ATPase dependent transmembrane transport complex ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex transporter complex ATP-binding cassette (ABC) transporter complex cell periphery cellular anatomical structure transmembrane transporter complex outer membrane-bounded periplasmic space cell envelope periplasmic space membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membraneless organelle nucleolus intracellular organelle lumen organelle lumen membraneless organelle nuclear lumen cytosol nuclear protein-containing complex supraspliceosomal complex spliceosomal complex ribonucleoprotein complex nucleoplasm
C	RNA (71-MER)	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR006060	Maltose/Cyclodextrin ABC transporter, substrate-binding protein	Family
A, B	IPR006059	Bacterial-type extracellular solute-binding protein	Family
A, B	IPR006061	Solute-binding family 1, conserved site	Conserved Site
A, B	IPR044456	ADAR1, first double-stranded RNA binding domain	Domain
A, B	IPR002466	Adenosine deaminase/editase	Domain
A, B	IPR042371	Z-binding domain	Domain
A, B	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A, B	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
A, B	IPR044457	ADAR1, third double-stranded RNA binding domain	Domain
A, B	IPR014720	Double-stranded RNA-binding domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P55265	Aicardi-Goutieres syndrome dyschromatosis symmetrica hereditaria Aicardi-Goutieres syndrome 6 breast carcinoma ovarian cancer pseudo-TORCH syndrome Duchenne muscular dystrophy familial infantile bilateral striatal necrosis juvenile dermatomyositis Mammary Neoplasms pancreatic intraductal papillary-mucinous neoplasm Aicardi-Goutieres syndrome 1 astrocytic tumor cutaneous lupus erythematosus infantile bilateral striatal necrosis Aicardi-Goutieres syndrome dyschromatosis symmetrica hereditaria Aicardi-Goutieres syndrome 6 breast carcinoma ovarian cancer pseudo-TORCH syndrome Duchenne muscular dystrophy familial infantile bilateral striatal necrosis juvenile dermatomyositis Mammary Neoplasms pancreatic intraductal papillary-mucinous neoplasm Aicardi-Goutieres syndrome 1 astrocytic tumor cutaneous lupus erythematosus infantile bilateral striatal necrosis leukodystrophy plasma cell myeloma Aicardi-Goutieres syndrome 2 breast cancer dermatomyositis intellectual disability

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.