9ITG | pdb_00009itg

Cryo-EM structure of human XPR1-E622A/F623A mutant in complex with InsP6 in inward-facing state in the presence of 10 mM KH2PO4

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Solute carrier family 53 member 1	protein binding binding virus receptor activity exogenous protein binding ion binding inositol hexakisphosphate binding alcohol binding anion binding small molecule binding active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity transporter activity transmembrane transporter activity inorganic anion transmembrane transporter activity protein binding binding virus receptor activity exogenous protein binding ion binding inositol hexakisphosphate binding alcohol binding anion binding small molecule binding active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity transporter activity transmembrane transporter activity inorganic anion transmembrane transporter activity phosphate transmembrane transporter activity secondary active transmembrane transporter activity efflux transmembrane transporter activity	biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to external stimulus response to external biotic stimulus response to virus response to biotic stimulus phosphate ion homeostasis intracellular phosphate ion homeostasis cellular homeostasis inorganic ion homeostasis chemical homeostasis homeostatic process intracellular chemical homeostasis biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to external stimulus response to external biotic stimulus response to virus response to biotic stimulus phosphate ion homeostasis intracellular phosphate ion homeostasis cellular homeostasis inorganic ion homeostasis chemical homeostasis homeostatic process intracellular chemical homeostasis localization transport phosphate ion transport establishment of localization inorganic anion transport cellular response to stimulus cellular response to nutrient levels response to nutrient levels cellular response to phosphate starvation cellular response to stress response to stress cellular process response to starvation cellular response to starvation transmembrane transport phosphate ion transmembrane transport inorganic ion transmembrane transport inorganic anion transmembrane transport	cell periphery cellular anatomical structure plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR004331	SPX domain	Domain
A, B	IPR004342	EXS, C-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q9UBH6	basal ganglia calcification, idiopathic, 6 basal ganglia disease basal ganglia calcification, idiopathic, 1 bilateral striopallidodentate calcinosis calcinosis primitive neuroectodermal tumor atypical teratoid rhabdoid tumor Creutzfeldt Jacob disease glioblastoma malignant ependymoma Microcalcification ovarian cancer ductal breast carcinoma in situ juvenile dermatomyositis malignant glioma basal ganglia calcification, idiopathic, 6 basal ganglia disease basal ganglia calcification, idiopathic, 1 bilateral striopallidodentate calcinosis calcinosis primitive neuroectodermal tumor atypical teratoid rhabdoid tumor Creutzfeldt Jacob disease glioblastoma malignant ependymoma Microcalcification ovarian cancer ductal breast carcinoma in situ juvenile dermatomyositis malignant glioma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia medulloblastoma osteosarcoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.