9GH5 | pdb_00009gh5

Complex of Fusobacterium nucleatum CbpF with human CEACAM1

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF05662	Coiled stalk of trimeric autotransporter adhesin (YadA_stalk)	Coiled stalk of trimeric autotransporter adhesin	-	Motif
A, B, C	PF05658	YadA head domain repeat (2 copies) (YadA_head)	YadA head domain repeat (2 copies)	-	Repeat
D, E, F	PF07686	Immunoglobulin V-set domain (V-set)	Immunoglobulin V-set domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	Domain
D, E, F	PF13927	Immunoglobulin domain (Ig_3)	Immunoglobulin domain	This family contains immunoglobulin-like domains.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Cell surface protein	-	protein localization establishment of protein localization cellular localization nitrogen compound transport transport establishment of localization localization protein transport cellular macromolecule localization macromolecule localization cellular process	cell surface cellular anatomical structure cell periphery cell outer membrane external encapsulating structure membrane cell envelope outer membrane
D, E, F	Carcinoembryonic antigen-related cell adhesion molecule 1	cytoskeletal protein binding protein binding binding filamin binding lipid transporter activity lipid transmembrane transporter activity transporter activity monocarboxylic acid transmembrane transporter activity carboxylic acid transmembrane transporter activity organic acid transmembrane transporter activity transmembrane transporter activity organic anion transmembrane transporter activity bile acid transmembrane transporter activity protein phosphatase binding cytoskeletal protein binding protein binding binding filamin binding lipid transporter activity lipid transmembrane transporter activity transporter activity monocarboxylic acid transmembrane transporter activity carboxylic acid transmembrane transporter activity organic acid transmembrane transporter activity transmembrane transporter activity organic anion transmembrane transporter activity bile acid transmembrane transporter activity protein phosphatase binding phosphatase binding enzyme binding calmodulin binding protein dimerization activity protein tyrosine kinase binding kinase binding protein kinase binding identical protein binding protein homodimerization activity actin binding	regulation of biosynthetic process regulation of biological process regulation of cellular process regulation of lipid metabolic process negative regulation of metabolic process biological regulation negative regulation of biological process lipid biosynthetic process primary metabolic process negative regulation of lipid biosynthetic process regulation of primary metabolic process biosynthetic process negative regulation of biosynthetic process negative regulation of cellular process regulation of biosynthetic process regulation of biological process regulation of cellular process regulation of lipid metabolic process negative regulation of metabolic process biological regulation negative regulation of biological process lipid biosynthetic process primary metabolic process negative regulation of lipid biosynthetic process regulation of primary metabolic process biosynthetic process negative regulation of biosynthetic process negative regulation of cellular process metabolic process cellular process regulation of lipid biosynthetic process regulation of metabolic process negative regulation of lipid metabolic process lipid metabolic process multicellular organismal process regulation of developmental process cellular developmental process positive regulation of biological process regulation of vasculogenesis regulation of cell differentiation vasculogenesis positive regulation of developmental process multicellular organism development tube morphogenesis positive regulation of cell differentiation cell differentiation anatomical structure development positive regulation of cellular process blood vessel development system development developmental process blood vessel morphogenesis tube development vasculature development circulatory system development anatomical structure morphogenesis positive regulation of vasculogenesis regulation of cell motility endothelial cell migration regulation of locomotion regulation of cell migration regulation of endothelial cell migration cell migration cell motility locomotion regulation of body fluid levels response to stimulus regulation of cell activation negative regulation of cell adhesion negative regulation of platelet activation regulation of coagulation regulation of biological quality response to wounding negative regulation of homotypic cell-cell adhesion negative regulation of wound healing negative regulation of blood coagulation response to external stimulus blood coagulation negative regulation of hemostasis regulation of platelet activation regulation of response to stimulus negative regulation of response to external stimulus negative regulation of cell-cell adhesion regulation of wound healing negative regulation of multicellular organismal process platelet activation regulation of response to external stimulus homotypic cell-cell adhesion regulation of response to wounding cell adhesion cell-cell adhesion response to stress regulation of response to stress coagulation regulation of cell-cell adhesion regulation of multicellular organismal process regulation of hemostasis wound healing negative regulation of response to stimulus regulation of homotypic cell-cell adhesion regulation of cell adhesion regulation of blood coagulation hemostasis cell activation negative regulation of platelet aggregation negative regulation of response to wounding platelet aggregation negative regulation of cell activation regulation of platelet aggregation negative regulation of coagulation regulation of tissue remodeling regulation of blood vessel remodeling blood vessel remodeling tissue remodeling regulation of anatomical structure morphogenesis regulation of sprouting angiogenesis angiogenesis regulation of vasculature development regulation of multicellular organismal development sprouting angiogenesis regulation of angiogenesis anatomical structure formation involved in morphogenesis regulation of growth regulation of cellular component organization growth regulation of cell growth cell growth cellular component organization cellular component organization or biogenesis cellular response to stimulus cell surface receptor signaling pathway signaling granulocyte colony-stimulating factor signaling pathway response to cytokine cytokine-mediated signaling pathway cell communication response to peptide response to chemical cellular response to cytokine stimulus signal transduction organic anion transport carboxylic acid transport transport lipid localization bile acid and bile salt transport lipid transport organic hydroxy compound transport establishment of localization organic acid transport localization monocarboxylic acid transport macromolecule localization negative regulation of vascular permeability regulation of vascular permeability system process circulatory system process vascular process in circulatory system blood circulation immune system process regulation of immune system process regulation of ERBB signaling pathway regulation of signaling regulation of signal transduction cell surface receptor protein tyrosine kinase signaling pathway regulation of epidermal growth factor receptor signaling pathway ERBB signaling pathway regulation of cell communication epidermal growth factor receptor signaling pathway enzyme-linked receptor protein signaling pathway interleukin-1 production negative regulation of interleukin-1 production regulation of cytokine production cytokine production negative regulation of macromolecule metabolic process regulation of interleukin-1 production negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression negative regulation of gene expression negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of protein modification process regulation of catalytic activity regulation of protein phosphorylation negative regulation of phosphate metabolic process negative regulation of catalytic activity regulation of transferase activity negative regulation of kinase activity negative regulation of transferase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process protein metabolic process phosphorus metabolic process protein modification process negative regulation of protein metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process negative regulation of molecular function negative regulation of protein kinase activity regulation of protein kinase activity regulation of molecular function regulation of kinase activity negative regulation of protein phosphorylation macromolecule modification negative regulation of phosphorus metabolic process regulation of phosphorylation regulation of phosphorus metabolic process negative regulation of phosphorylation import into cell insulin receptor internalization receptor internalization receptor-mediated endocytosis endocytosis vesicle-mediated transport adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity regulation of immune effector process T cell mediated immunity negative regulation of lymphocyte mediated immunity regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains negative regulation of leukocyte mediated cytotoxicity leukocyte mediated immunity negative regulation of cell killing regulation of T cell mediated immunity T cell mediated cytotoxicity immune response regulation of adaptive immune response negative regulation of immune response negative regulation of T cell mediated cytotoxicity negative regulation of immune effector process regulation of leukocyte mediated cytotoxicity negative regulation of adaptive immune response leukocyte mediated cytotoxicity adaptive immune response immune effector process negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of leukocyte mediated immunity regulation of T cell mediated cytotoxicity regulation of lymphocyte mediated immunity negative regulation of immune system process regulation of immune response regulation of cell killing negative regulation of leukocyte mediated immunity negative regulation of T cell mediated immunity cell killing immune response to tumor cell negative regulation of immune response to tumor cell response to biotic stimulus negative regulation of natural killer cell mediated immunity regulation of natural killer cell mediated cytotoxicity directed against tumor cell target regulation of natural killer cell mediated immune response to tumor cell natural killer cell mediated immunity regulation of natural killer cell mediated immunity negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target response to other organism regulation of innate immune response natural killer cell mediated immune response to tumor cell defense response to other organism negative regulation of defense response natural killer cell mediated cytotoxicity regulation of defense response negative regulation of natural killer cell mediated cytotoxicity regulation of response to biotic stimulus regulation of natural killer cell mediated cytotoxicity biological process involved in interspecies interaction between organisms negative regulation of response to biotic stimulus negative regulation of response to tumor cell regulation of response to tumor cell innate immune response response to external biotic stimulus response to tumor cell defense response defense response to symbiont regulation of immune response to tumor cell natural killer cell mediated cytotoxicity directed against tumor cell target negative regulation of natural killer cell mediated immune response to tumor cell negative regulation of innate immune response immune response-regulating cell surface receptor signaling pathway negative regulation of signaling regulation of antigen receptor-mediated signaling pathway negative regulation of antigen receptor-mediated signaling pathway negative regulation of cell communication positive regulation of response to stimulus immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response positive regulation of immune system process immune response-activating cell surface receptor signaling pathway regulation of T cell receptor signaling pathway T cell receptor signaling pathway negative regulation of signal transduction negative regulation of T cell receptor signaling pathway antigen receptor-mediated signaling pathway activation of immune response regulation of MAPK cascade intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade cell-cell adhesion via plasma-membrane adhesion molecules homophilic cell adhesion via plasma membrane adhesion molecules cell population proliferation common myeloid progenitor cell proliferation integrin-mediated signaling pathway myeloid leukocyte differentiation regulation of leukocyte differentiation regulation of granulocyte differentiation cell development regulation of cell development negative regulation of cell differentiation negative regulation of hemopoiesis negative regulation of leukocyte differentiation hemopoiesis negative regulation of developmental process regulation of myeloid cell differentiation negative regulation of myeloid cell differentiation regulation of myeloid leukocyte differentiation negative regulation of myeloid leukocyte differentiation negative regulation of cell development negative regulation of granulocyte differentiation granulocyte differentiation myeloid cell differentiation regulation of hemopoiesis leukocyte differentiation regulation of localization regulated exocytosis negative regulation of transport cell activation involved in immune response leukocyte degranulation negative regulation of cytotoxic T cell degranulation negative regulation of secretion T cell activation establishment of localization in cell cytotoxic T cell degranulation negative regulation of secretion by cell regulation of secretion exocytosis cellular localization lymphocyte activation negative regulation of regulated secretory pathway negative regulation of leukocyte degranulation leukocyte activation regulation of regulated secretory pathway secretion by cell regulation of secretion by cell T cell activation involved in immune response negative regulation of exocytosis leukocyte activation involved in immune response regulation of leukocyte degranulation lymphocyte activation involved in immune response secretion regulation of transport export from cell regulation of vesicle-mediated transport regulation of exocytosis regulation of cytotoxic T cell degranulation regulation of hepatocyte proliferation gland development liver development gland morphogenesis animal organ morphogenesis epithelial cell proliferation liver morphogenesis negative regulation of cell population proliferation animal organ development epithelial cell proliferation involved in liver morphogenesis hepatocyte proliferation regulation of cell population proliferation hepaticobiliary system development negative regulation of hepatocyte proliferation regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation epithelium development endothelial cell differentiation endothelium development regulation of endothelial cell differentiation tissue development epithelial cell differentiation regulation of epithelial cell differentiation regulation of homophilic cell adhesion cellular response to nitrogen compound response to endogenous stimulus response to peptide hormone response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to chemical stimulus response to hormone response to insulin cellular response to insulin stimulus cellular response to hormone stimulus morphogenesis of an epithelium epiboly involved in wound healing morphogenesis of an epithelial sheet tissue morphogenesis epiboly wound healing, spreading of cells negative regulation of small molecule metabolic process oxoacid metabolic process ketone metabolic process organic acid metabolic process organic acid biosynthetic process carboxylic acid biosynthetic process regulation of small molecule metabolic process small molecule metabolic process negative regulation of fatty acid biosynthetic process fatty acid metabolic process negative regulation of fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process carboxylic acid metabolic process fatty acid biosynthetic process regulation of ketone metabolic process regulation of fatty acid metabolic process regulation of fatty acid biosynthetic process monocarboxylic acid metabolic process regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction insulin catabolic process catabolic process protein catabolic process insulin metabolic process macromolecule catabolic process	membrane-bounded organelle intracellular anatomical structure membrane intracellular vesicle intracellular membrane-bounded organelle endomembrane system specific granule membrane intracellular organelle cytoplasmic vesicle membrane cellular anatomical structure bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle membrane-bounded organelle intracellular anatomical structure membrane intracellular vesicle intracellular membrane-bounded organelle endomembrane system specific granule membrane intracellular organelle cytoplasmic vesicle membrane cellular anatomical structure bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle organelle membrane secretory granule membrane specific granule cell-cell junction anchoring junction cell junction extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle plasma membrane plasma membrane bounded cell projection cell periphery cell projection actin-based cell projection plasma membrane region microvillus microvillus membrane cell projection membrane adherens junction transport vesicle transport vesicle membrane tertiary granule membrane tertiary granule apical part of cell apical plasma membrane basal part of cell basal plasma membrane cell surface lateral plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR008635	Trimeric autotransporter adhesin YadA-like, stalk domain	Domain
A, B, C	IPR008640	Trimeric autotransporter adhesin YadA-like, head domain	Domain
A, B, C	IPR005594	Trimeric autotransporter adhesin YadA-like, C-terminal membrane anchor domain	Domain
A, B, C	IPR011049	Serralysin-like metalloprotease, C-terminal	Homologous Superfamily
A, B, C	IPR045584	Pilin-like	Homologous Superfamily
D, E, F	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
D, E, F	IPR013106	Immunoglobulin V-set domain	Domain
D, E, F	IPR003599	Immunoglobulin domain subtype	Domain
D, E, F	IPR013151	Immunoglobulin-like beta-sandwich domain	Domain
D, E, F	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
D, E, F	IPR007110	Immunoglobulin-like domain	Domain
D, E, F	IPR003598	Immunoglobulin subtype 2	Domain
D, E, F	IPR050831	Carcinoembryonic antigen-related cell adhesion	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
D, E, F	Pharos: P13688	granular cell carcinoma tubular adenocarcinoma adenocarcinoma malignant pancreatic neoplasm osteosarcoma pancreatic intraductal papillary-mucinous neoplasm psoriasis Spontaneous abortion cribriform carcinoma of breast lung adenocarcinoma malignant mesothelioma MALT lymphoma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia sinusitis granular cell carcinoma tubular adenocarcinoma adenocarcinoma malignant pancreatic neoplasm osteosarcoma pancreatic intraductal papillary-mucinous neoplasm psoriasis Spontaneous abortion cribriform carcinoma of breast lung adenocarcinoma malignant mesothelioma MALT lymphoma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia sinusitis Crohn disease head and neck cancer lung benign neoplasm lymphoplasmacytic lymphoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma pituitary cancer Sjogren syndrome cribriform carcinoma cystic fibrosis large cell medulloblastoma lung cancer malignant colon neoplasm

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.