Download MendeleyStructure basis of ligand selectivity and signal transduction in human melanocortin-3 receptor
Jingpeng, F., Hongli, H.To be published.
8W8Y | pdb_00008w8y
Cryo-EM structure of gamma-MSH-MC3R-Gs_Nb35 complex
- PDB DOI: https://doi.org/10.2210/pdb8W8Y/pdb
- EM Map EMD-37361: EMDB EMDataResource
- Classification: MEMBRANE PROTEIN
- Organism(s): Escherichia coli, Homo sapiens, Rattus norvegicus, Bos taurus, Lama glama
- Expression System: Spodoptera frugiperda, Eschenbachia
- Mutation(s): No
- Membrane Protein: Yes PDBTMMemProtMD
- Deposited: 2023-09-04 Released: 2025-03-19
- Funding Organization(s): Other government, Other private
Experimental Data Snapshot
- Method: ELECTRON MICROSCOPY
- Resolution: 2.90 Å
- Aggregation State: PARTICLE
- Reconstruction Method: SINGLE PARTICLE
wwPDB Validation 3D Report Full Report
This is version 1.0 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Soluble cytochrome b562,Melanocortin receptor 3,Fusion protein | A [auth R] | 602 | Escherichia coli, Homo sapiens | Mutation(s): 0 Gene Names: cybC, MC3R Membrane Entity: Yes |  |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P0ABE7 (Escherichia coli) Explore P0ABE7 Go to UniProtKB: P0ABE7 | |||||
Find proteins for P41968 (Homo sapiens) Explore P41968 Go to UniProtKB: P41968 | |||||
PHAROS: P41968 GTEx: ENSG00000124089 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Groups | P0ABE7P41968 | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by: Sequence | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Gama-MSH | B [auth L] | 11 | Homo sapiens | Mutation(s): 0 |  |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 3 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | C [auth B] | 384 | Rattus norvegicus | Mutation(s): 0 Gene Names: Gnb1 |  |
UniProt | |||||
Find proteins for P54311 (Rattus norvegicus) Explore P54311 Go to UniProtKB: P54311 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P54311 | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 4 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | D [auth G] | 71 | Bos taurus | Mutation(s): 0 Gene Names: GNG2 Membrane Entity: Yes |  |
UniProt | |||||
Find proteins for P63212 (Bos taurus) Explore P63212 Go to UniProtKB: P63212 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P63212 | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 5 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Nanobody35 | E [auth N] | 160 | Lama glama | Mutation(s): 0 |  |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 6 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | F [auth A] | 380 | Homo sapiens | Mutation(s): 0 Gene Names: GNAS, GNAS1, GSP EC: 3.6.5 Membrane Entity: Yes |  |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P63092 (Homo sapiens) Explore P63092 Go to UniProtKB: P63092 | |||||
PHAROS: P63092 GTEx: ENSG00000087460 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P63092 | ||||
Sequence AnnotationsExpand | |||||
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Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| CA (Subject of Investigation/LOI) Query on CA | G [auth R] | CALCIUM ION Ca BHPQYMZQTOCNFJ-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: ELECTRON MICROSCOPY
- Resolution: 2.90 Å
- Aggregation State: PARTICLE
- Reconstruction Method: SINGLE PARTICLE
| Task | Software Package | Version |
|---|---|---|
| MODEL REFINEMENT | PHENIX | 1.20.1_4487: |
Entry History & Funding Information
Deposition Data
| Funding Organization | Location | Grant Number |
|---|---|---|
| Other government | Shenzhen Science and Technology Innovation Committee | |
| Other private | Ganghong Young Scholar Development Fund |
Revision History (Full details and data files)
- Version 1.0: 2025-03-19
Type: Initial release
