TUG-1375 and 4-CMTB-bound human FFA2 in complex with Gi
Kugawa, M., Kawakami, K., Kise, R., Kobayashi, K., Kojima, A., Inoue, W., Fukuda, M., Inoue, A., Kato, H.E.To be published.
Experimental Data Snapshot
wwPDB Validation   3D Report Full Report
Entity ID: 1 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
Guanine nucleotide-binding protein G(i) subunit alpha-1 | 354 | Homo sapiens | Mutation(s): 0  Gene Names: GNAI1 EC: 3.6.5 | ![]() | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P63096 (Homo sapiens) Explore P63096  Go to UniProtKB:  P63096 | |||||
PHAROS:  P63096 GTEx:  ENSG00000127955  | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P63096 | ||||
Sequence AnnotationsExpand | |||||
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Entity ID: 2 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 357 | Homo sapiens | Mutation(s): 0  Gene Names: GNB1 | ![]() | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P62873 (Homo sapiens) Explore P62873  Go to UniProtKB:  P62873 | |||||
PHAROS:  P62873 GTEx:  ENSG00000078369  | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P62873 | ||||
Sequence AnnotationsExpand | |||||
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Entity ID: 3 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | 71 | Homo sapiens | Mutation(s): 0  Gene Names: GNG2 | ![]() | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P59768 (Homo sapiens) Explore P59768  Go to UniProtKB:  P59768 | |||||
PHAROS:  P59768 GTEx:  ENSG00000186469  | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P59768 | ||||
Sequence AnnotationsExpand | |||||
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Entity ID: 4 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
scFv16 | 259 | Mus musculus | Mutation(s): 0  | ![]() | |
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
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Entity ID: 5 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
Free fatty acid receptor 2 | E [auth R] | 362 | Homo sapiens | Mutation(s): 0  Gene Names: FFAR2, FFA2, GPCR43, GPR43 | ![]() |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for O15552 (Homo sapiens) Explore O15552  Go to UniProtKB:  O15552 | |||||
PHAROS:  O15552 GTEx:  ENSG00000126262  | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | O15552 | ||||
Sequence AnnotationsExpand | |||||
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Ligands 2 Unique | |||||
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ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
9UJ (Subject of Investigation/LOI) Query on 9UJ | F [auth R] | (2R,4R)-2-(2-chlorophenyl)-3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]carbonyl-1,3-thiazolidine-4-carboxylic acid C22 H19 Cl N2 O4 S RZAMDGBOOPJHJQ-GHTZIAJQSA-N | |||
A1LYC (Subject of Investigation/LOI) Query on A1LYC | G [auth R] | (2~{S})-2-(4-chlorophenyl)-3-methyl-~{N}-(1,3-thiazol-2-yl)butanamide C14 H15 Cl N2 O S AZYDQCGCBQYFSE-LBPRGKRZSA-N |
Funding Organization | Location | Grant Number |
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Japan Society for the Promotion of Science (JSPS) | Japan | 21H05142 |
Japan Society for the Promotion of Science (JSPS) | Japan | 21H04791 |