Cryo-EM structure of GPCR16-miniGs complex
Wang, X., Wu, L.J., Hua, T., Liu, Z.J.To be published.
Experimental Data Snapshot
Starting Model: in silico
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wwPDB Validation   3D Report Full Report
Entity ID: 1 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Guanine nucleotide-binding protein G(t) subunit alpha-3 | 264 | Homo sapiens | Mutation(s): 0  Gene Names: GNAS, GNAS1, GSP EC: 3.6.5 | ![]() | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P63092 (Homo sapiens) Explore P63092  Go to UniProtKB:  P63092 | |||||
PHAROS:  P63092 GTEx:  ENSG00000087460  | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P63092 | ||||
Sequence AnnotationsExpand | |||||
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Entity ID: 2 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 366 | Homo sapiens | Mutation(s): 0  Gene Names: GNB1 | ![]() | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P62873 (Homo sapiens) Explore P62873  Go to UniProtKB:  P62873 | |||||
PHAROS:  P62873 GTEx:  ENSG00000078369  | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P62873 | ||||
Sequence AnnotationsExpand | |||||
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Entity ID: 3 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | C [auth G] | 71 | Homo sapiens | Mutation(s): 0  Gene Names: GNG2 | ![]() |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P59768 (Homo sapiens) Explore P59768  Go to UniProtKB:  P59768 | |||||
PHAROS:  P59768 GTEx:  ENSG00000186469  | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P59768 | ||||
Sequence AnnotationsExpand | |||||
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Entity ID: 4 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
Nanobody 35 | D [auth N] | 135 | Homo sapiens | Mutation(s): 0  | ![]() |
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
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Entity ID: 5 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
Fusion protein 1,exo-alpha-sialidase,Taste receptor type 2 member 16,Fusion protein 2,exo-alpha-sialidase,Taste receptor type 2 member 16 | E [auth R] | 1,011 | Homo sapiens, Streptococcus pneumoniae | Mutation(s): 0  EC: 3.2.1.18 | ![]() |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for A0A4J1WX37 (Streptococcus pneumoniae) Explore A0A4J1WX37  Go to UniProtKB:  A0A4J1WX37 | |||||
Find proteins for Q9NYV7 (Homo sapiens) Explore Q9NYV7  Go to UniProtKB:  Q9NYV7 | |||||
PHAROS:  Q9NYV7 GTEx:  ENSG00000128519  | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Groups | A0A4J1WX37Q9NYV7 | ||||
Sequence AnnotationsExpand | |||||
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Ligands 1 Unique | |||||
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ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
SA0 (Subject of Investigation/LOI) Query on SA0 | F [auth R] | 2-(hydroxymethyl)phenyl beta-D-glucopyranoside C13 H18 O7 NGFMICBWJRZIBI-UJPOAAIJSA-N |
Task | Software Package | Version |
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MODEL REFINEMENT | PHENIX |
Funding Organization | Location | Grant Number |
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Chinese Academy of Sciences | China | XDB37030104 |